Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jianling Zou"'
Autor:
Yan Li, Bing Wang, Wentao Yang, Fahan Ma, Jianling Zou, Kai Li, Subei Tan, Jinwen Feng, Yunzhi Wang, Zhaoyu Qin, Zhiyu Chen, Chen Ding
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Cetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 plasma samples originated from 147 CRC patients (CRCs) unde
Externí odkaz:
https://doaj.org/article/47f3ea5d41964527b62e898ed7d6c440
Autor:
Yujiao Wang, Xi Jiao, Shuang Li, Huan Chen, Xin Wei, Chang Liu, Jifang Gong, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Yanni Wang, Na Zhuo, Jianling Zou, Henghui Zhang, Jian Li, Lin Shen, Zhihao Lu
Publikováno v:
Cancer Biology & Medicine, Vol 19, Iss 8, Pp 1139-1149 (2022)
Objective: Immune checkpoint inhibitors (ICIs) have achieved remarkable results in cancer treatments. However, there is no effective predictive biomarker for gastrointestinal (GI) cancer. Methods: We conducted integrative analyses of the genomic and
Externí odkaz:
https://doaj.org/article/b66317dbdff54c3ba4126d1afc0e6ce5
Autor:
Zhihao Lu, Huan Chen, Xi Jiao, Yujiao Wang, Lijia Wu, Huaibo Sun, Shuang Li, Jifang Gong, Jian Li, Jianling Zou, Keyan Yang, Ying Hu, Beibei Mao, Lei Zhang, Xiaotian Zhang, Zhi Peng, Ming Lu, Zhenghang Wang, Henghui Zhang, Lin Shen
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background The human leukocyte antigen class I (HLA-I) genotype has been linked with differential immune responses to infectious disease and cancer. However, the clinical relevance of germline HLA-mediated immunity in gastrointestinal (GI) c
Externí odkaz:
https://doaj.org/article/7fe821b76fe44e51931ca85d2de5d647
Autor:
Yanni Wang, Jianling Zou, Yun Li, Xi Jiao, Yujiao Wang, Na Zhuo, Mengting Gao, Jifang Gong, Jian Li, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Jie Li, Yan Li, Lin Shen, Henghui Zhang, Zhihao Lu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundImmune checkpoint inhibitors (ICIs) have dramatically improved survival in advanced gastrointestinal (GI) cancer patients, but also resulted in immune-related adverse events (irAEs). This study aimed to evaluate serological biomarkers of ir
Externí odkaz:
https://doaj.org/article/c6fcdb6f36db48fda0006d5277c0fd76
Autor:
Wentao Yang, Jianling Zou, Ye Li, Rujiao Liu, Zhengqing Yan, Shiqing Chen, Xiaoying Zhao, Weijian Guo, Mingzhu Huang, Wenhua Li, Xiaodong Zhu, Zhiyu Chen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/4ec7ad7aed1a4690ba966b5c81fab1fc
Autor:
Wentao Yang, Jianling Zou, Ye Li, Rujiao Liu, Zhengqing Yan, Shiqing Chen, Xiaoying Zhao, Weijian Guo, Mingzhu Huang, Wenhua Li, Xiaodong Zhu, Zhiyu Chen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundMetastatic colorectal cancer (mCRC) is a heterogenous disease with limited precision medicine and targeted therapy options. Monoclonal antibodies against epidermal growth factor receptor (EGFR) have been a crucial treatment option for mCRC.
Externí odkaz:
https://doaj.org/article/9cb61b04dd2e434e87a2b7bdd6a69b77
Autor:
Lin Shen, Huan Chen, Ming Lu, Shuang Li, Henghui Zhang, Jifang Gong, Zhihao Lu, Zhi Peng, Xi Jiao, Lihong Wu, Wenbo Han, Jianling Zou, Jianing Yu, Huaibo Sun
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Despite the great achievements made in immune-checkpoint-blockade (ICB) in cancer therapy, there are no effective predictive biomarkers in gastrointestinal (GI) cancer.Methods This study included 93 metastatic GI patients treated with ICBs
Externí odkaz:
https://doaj.org/article/d766e6f16abe4c22a03534e640902608
Autor:
Jianling Zou, Ying Liu, Jingyuan Wang, Zhentao Liu, Zhihao Lu, Zuhua Chen, Zhongwu Li, Bin Dong, Wenwen Huang, Yanyan Li, Jing Gao, Lin Shen
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-11 (2018)
Abstract Background Squamous cell carcinoma is the dominant type of esophageal cancer in China with many patients initially diagnosed at advanced stage. Patient-derived xenografts (PDX) models have been developed to be an important platform for precl
Externí odkaz:
https://doaj.org/article/3c2350eeb2fc403ca4f2ce839256900a
Autor:
Zuhua Chen, Zhentao Liu, Wenwen Huang, Zhongwu Li, Jianling Zou, Jingyuan Wang, Xiaoting Lin, Beifang Li, Dongshao Chen, Yanting Hu, Jiafu Ji, Jing Gao, Lin Shen
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-11 (2017)
Abstract Background We investigated antitumor activity and underlying mechanisms of DNA topoisomerase I (TopI) inhibitor gimatecan and irinotecan in gastric cancer (GC) in vitro cell lines and in vivo patient-derived xenograft (PDX) models. Methods G
Externí odkaz:
https://doaj.org/article/44ef5399115d4c1c8bfec5353fa5026e
Autor:
Mifen Chen, Zhenghang Wang, Zimin Liu, Ting Deng, Xiaodong Wang, Zhiwei Chang, Qi Zhang, Wenlei Yang, Ning Liu, Zhi Ji, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Yi Li, Yujuan Cao, Xuan Jin, Hongxia Lu, Huajun Qu, Yong Tang, Chunlei Xu, Weijia Fang, Hangyu Zhang, Dong Yan, Li Wang, Jiayi Li, Jingdong Zhang, Qiwei Wang, Liying Xue, Fei Yin, Guangjie Han, Zhiqiang Cheng, Qing Liu, Yongdong Jin, Yinjie Zhang, Lanxing Li, Baoshan Cao, Yanhong Yao, Zhiyu Chen, Jianling Zou, Jieer Ying, Qing Wei, Tiantian Tian, Weifeng Zhao, Longmei Li, Tong Zhang, Fanghua Song, Ya-er Ba, Na Li, Hui Gao, Yinghua Ji, Liying Bao, Xiaochen Zhao, Jinping Cai, Zheping Yuan, Lin Shen, Jian Li
Publikováno v:
JCO Precision Oncology.
PURPOSE To investigate the efficacy of PD-1/PD-L1 inhibitors plus chemotherapy versus anti–PD-1/PD-L1 monotherapy in advanced microsatellite instability (MSI)/mismatch repair-deficient (dMMR) gastrointestinal cancers. METHODS We retrospectively rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7524adca41c7f5476c1f50f9318a2697
https://doi.org/10.1200/po.22.00463
https://doi.org/10.1200/po.22.00463