Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jianlin Chu"'
Publikováno v:
JACS Au, Vol 4, Iss 2, Pp 454-464 (2024)
Externí odkaz:
https://doaj.org/article/6cbad1ff34cb468c8c363355ea89ac17
Publikováno v:
Applied Sciences, Vol 14, Iss 16, p 7320 (2024)
N-glycan, a critical quality attribute (CQA) of monoclonal antibodies, profoundly impacts potency, immunogenicity, safety, and clinical efficiency. Therefore, N-glycan should be monitored and controlled during development. The conventional 2-AB metho
Externí odkaz:
https://doaj.org/article/4f0c4fdddcc44aa3858a957cbbd4622f
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 999 (2024)
Co-formulated antibodies can bring clinical benefits to patients by combining two or more antibodies in a single dosage form. However, the quality analysis of co-formulated antibodies raises additional challenges, compared to individual antibodies, d
Externí odkaz:
https://doaj.org/article/b47077ce5bbd4829bcde659b55c8ae9b
Publikováno v:
Catalysts, Vol 11, Iss 1, p 132 (2021)
Rare ginsenoside Rh2 exhibits diverse pharmacological effects. UDP-glycosyltransferase (UGT) catalyzed glycosylation of protopanaxadiol (PPD) has been of growing interest in recent years. UDP-glycosyltransferase Bs-YjiC coupling sucrose synthase in o
Externí odkaz:
https://doaj.org/article/d028104c49ed43228cce08968762e4f0
Publikováno v:
Molecules, Vol 25, Iss 1, p 100 (2019)
Purine nucleoside phosphorylases (PNPs) are promising biocatalysts for the synthesis of purine nucleoside analogs. Although a number of PNPs have been reported, the development of highly efficient enzymes for industrial applications is still in high
Externí odkaz:
https://doaj.org/article/37900f3be52647fb97b57b8f93194c0c
Autor:
Xiaofang Wang, Erin A. Kimbrel, Kumiko Ijichi, Debayon Paul, Adam S. Lazorchak, Jianlin Chu, Nicholas A. Kouris, Gregory J. Yavanian, Shi-Jiang Lu, Joel S. Pachter, Stephen J. Crocker, Robert Lanza, Ren-He Xu
Publikováno v:
Stem Cell Reports, Vol 3, Iss 1, Pp 115-130 (2014)
Current therapies for multiple sclerosis (MS) are largely palliative, not curative. Mesenchymal stem cells (MSCs) harbor regenerative and immunosuppressive functions, indicating a potential therapy for MS, yet the variability and low potency of MSCs
Externí odkaz:
https://doaj.org/article/9eca6fa52d0141f6ac4a9f4814c4ca0a
Publikováno v:
Journal of Agricultural and Food Chemistry. 70:9694-9702
Levan-type fructooligosaccharides (FOS) exhibit enhanced health-promoting prebiotic effects on gut microbiota. The wild type (WT) of β-fructofuranosidase Fru6 could mainly yield 6-ketose. Semirational design and mutagenesis of Fru6 were exploited to
Publikováno v:
Journal of Agricultural and Food Chemistry. 69:8695-8702
Polydatin, resveratrol-3-O-β-glucoside, possesses various biological activities. However, the regioselective glucosylation of resveratrol by UDP-glycosyltransferases (UGTs) constitutes a persistent problem. In this study, semi-rational design and it
Publikováno v:
Biotechnology and Bioprocess Engineering. 26:408-418
In the process of glycosyltransferase-catalyzed transglycosylation, the synthesis of uridine diphosphate sugars is generally thermodynamically disfavored. This study found that GTBP1 from Bacillus pumilus BF1 displayed the potential to reversely synt
Publikováno v:
Biochemical and Biophysical Research Communications. 546:111-117
Lipase immobilization with hydrophobic interaction is of interesting exploration, and some functionalized groups on supports are special for activity increasing. To achieved a good performance of cost-effective immobilization on macro-supports for fe