Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jianliang Fu"'
Autor:
Jin Lu, Jiawei Zhang, Xiuzhe Wang, Fang Yuan, Bo Xin, Jie Li, Quanjun Yang, Xingxia Li, Jianping Zhang, Xingyan Wang, Jianliang Fu, Cheng Guo
Publikováno v:
Brain Research Bulletin, Vol 212, Iss , Pp 110969- (2024)
Alzheimer's disease (AD) stands as the most prevalent neurodegenerative condition worldwide, and its correlation with microglial function is notably significant. Dl-3-n-butylphthalide (NBP), derived from the seeds of Apium graveolens L. (Chinese cele
Externí odkaz:
https://doaj.org/article/f4d1307c891844a7a7e201555dd84032
Autor:
Yaxuan Zhang, Jiawei Zhang, Yao Zhao, Yueqi Zhang, Lan Liu, Xiaofeng Xu, Xiuzhe Wang, Jianliang Fu
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-15 (2023)
Abstract Neuroinflammation plays critical roles in vascular dementia (VaD), the second leading cause of dementia, which can be induced by chronic cerebral hypoperfusion (CCH). NLRP3 inflammasome-induced pyroptosis, the inflammatory programmed cell de
Externí odkaz:
https://doaj.org/article/c1dd148f5977470e8b333296ed245693
Autor:
Yao Zhao, Jiawei Zhang, Yaling Zheng, Yaxuan Zhang, Xiao Jie Zhang, Hongmei Wang, Yu Du, Jian Guan, Xiuzhe Wang, Jianliang Fu
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-16 (2021)
Abstract Background Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a promising treatment target. Nicotinamide adenine dinucleotide (NAD+) shows anti-inflammatory and
Externí odkaz:
https://doaj.org/article/7ec82e0fbf854ae2a4a190dfc0a5dcba
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Although diabetic cognitive impairment is one of the most common complications of type 2 diabetes mellitus (T2DM), optimized therapeutic strategies are not available yet. Astragalosides IV (AS-IV) is a traditional Chinese medicine possessing diverse
Externí odkaz:
https://doaj.org/article/27e2a0679f434be8a39c39cd69623d58
Autor:
Jiawei Zhang, Yu Liu, Yaling Zheng, Yan Luo, Yu Du, Yao Zhao, Jian Guan, Xiaojie Zhang, Jianliang Fu
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-16 (2020)
Abstract Background Diabetes mellitus (DM) and chronic cerebral hypoperfusion(CCH)are both risk factors for cognitive impairment. However, whether DM and CCH can synergistically promote cognitive impairment and the related pathological mechanisms rem
Externí odkaz:
https://doaj.org/article/fa3f69c824644c45b59d9cebd9bd86f4
Publikováno v:
Cellular Physiology and Biochemistry, Vol 50, Iss 6, Pp 2216-2228 (2018)
Background/Aims: This study focused on evaluating the effect of MALAT1 and MDM2 on ischemic stroke through regulation of the p53 signaling pathway. Materials: Bioinformatics analysis was performed to identify abnormally expressed lncRNAs, mRNAs and t
Externí odkaz:
https://doaj.org/article/aaf775361f064af3acbb284fc1e1faf6
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Donepezil (DNP) is the first-line drug used for Alzheimer's disease (AD). However, the therapeutic response rate of patients to DNP varies from 20 to 60%. The main reason for the large differences in the clinical efficacy of DNP therapy is genetic fa
Externí odkaz:
https://doaj.org/article/ac472af91ccc48b6b91844c0a03f95f0
Publikováno v:
Mediators of Inflammation, Vol 2020 (2020)
Leptin participates in the inflammatory responses in multiple cell types and animal models. Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white mat
Externí odkaz:
https://doaj.org/article/4e7eb8bc37dd4c219a19cdb158292363
Autor:
Yaxuan Zhang, Jiawei Zhang, Yao Zhao, Yueqi Zhang, Lan Liu, Xiaofeng Xu, Xiuzhe Wang, Jianliang Fu
Background Neuroinflammation plays critical roles in vascular dementia (VaD), the second leading cause of dementia which can be induced by chronic cerebral hypoperfusion (CCH). NLRP3 inflammasome-induced pyroptosis, the inflammatory programmed cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15661ae1cbbcee2087f294b4ec6cf918
https://doi.org/10.21203/rs.3.rs-2384502/v1
https://doi.org/10.21203/rs.3.rs-2384502/v1
Autor:
Yao Zhao, Jiawei Zhang, Yaxuan Zhang, Yueqi Zhang, Xiaojie Zhang, Yaling Zheng, Hongmei Wang, Xiuzhe Wang, Jianliang Fu
Publikováno v:
International immunopharmacology. 108
Vascular cognitive impairment (VCI) is the second most common form of dementia. Andrographolide (Andro) shows potential effects in anti-inflammation, anti-oxidative stress, and anti-apoptosis. We have obtained 48 potential genes related to the effect