Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Jianliang, Song"'
BAG3: Nature’s Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular Glue
Autor:
Caitlyn M. Brenner, Muaaz Choudhary, Michael G. McCormick, David Cheung, Gavin P. Landesberg, Ju-Fang Wang, Jianliang Song, Thomas G. Martin, Joseph Y. Cheung, Hui-Qi Qu, Hakon Hakonarson, Arthur M. Feldman
Publikováno v:
Cells, Vol 12, Iss 6, p 937 (2023)
BAG3 is a 575 amino acid protein that is found throughout the animal kingdom and homologs have been identified in plants. The protein is expressed ubiquitously but is most prominent in cardiac muscle, skeletal muscle, the brain and in many cancers. W
Externí odkaz:
https://doaj.org/article/3da901bbcdc74b2c9ceef3cef1832caf
Autor:
JuFang Wang, Dhadendra Tomar, Thomas G. Martin, Shubham Dubey, Praveen K. Dubey, Jianliang Song, Gavin Landesberg, Michael G. McCormick, Valerie D. Myers, Salim Merali, Carmen Merali, Bonnie Lemster, Charles F. McTiernan, Kamel Khalili, Muniswamy Madesh, Joseph Y. Cheung, Jonathan A. Kirk, Arthur M. Feldman
Publikováno v:
JACC: Basic to Translational Science.
Autor:
Tijana Knezevic, PhD, Valerie D. Myers, MS, Feifei Su, MD, PhD, JuFang Wang, MD, Jianliang Song, MD, PhD, Xue-Qian Zhang, MD, Erhe Gao, MD, PhD, Guofeng Gao, MD, PhD, Muniswamy Madesh, PhD, Manish K. Gupta, PhD, Jennifer Gordon, PhD, Kristen N. Weiner, BS, Joseph Rabinowitz, PhD, Frederick V. Ramsey, PhD, Douglas G. Tilley, PhD, Kamel Khalili, PhD, Joseph Y. Cheung, MD, PhD, Arthur M. Feldman, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 647-656 (2016)
Mutations in Bcl-2–associated athanogene 3 (BAG3) were associated with skeletal muscle dysfunction and dilated cardiomyopathy. Retro-orbital injection of an adeno-associated virus serotype 9 expressing BAG3 (rAAV9-BAG3) significantly (p < 0.0001) i
Externí odkaz:
https://doaj.org/article/70f170720da34f2985f48ff26cb0cbfd
Autor:
Ama Dedo Okyere, Jianliang Song, Viren Patwa, Rhonda L. Carter, Nitya Enjamuri, Anna Maria Lucchese, Jessica Ibetti, Claudio de Lucia, Sarah M. Schumacher, Walter J. Koch, Joseph Y. Cheung, Jeffrey L. Benovic, Douglas G. Tilley
Publikováno v:
Cardiovascular Drugs and Therapy. 37:245-256
Autor:
Dhanendra Tomar, Zhiwei Dong, Santhanam Shanmughapriya, Diana A. Koch, Toby Thomas, Nicholas E. Hoffman, Shrishiv A. Timbalia, Samuel J. Goldman, Sarah L. Breves, Daniel P. Corbally, Neeharika Nemani, Joseph P. Fairweather, Allison R. Cutri, Xueqian Zhang, Jianliang Song, Fabián Jaña, Jianhe Huang, Carlos Barrero, Joseph E. Rabinowitz, Timothy S. Luongo, Sarah M. Schumacher, Michael E. Rockman, Alexander Dietrich, Salim Merali, Jeffrey Caplan, Peter Stathopulos, Rexford S. Ahima, Joseph Y. Cheung, Steven R. Houser, Walter J. Koch, Vickas Patel, Vishal M. Gohil, John W. Elrod, Sudarsan Rajan, Muniswamy Madesh
Publikováno v:
Cell Reports, Vol 15, Iss 8, Pp 1673-1685 (2016)
Mitochondrial Ca2+ Uniporter (MCU)-dependent mitochondrial Ca2+ uptake is the primary mechanism for increasing matrix Ca2+ in most cell types. However, a limited understanding of the MCU complex assembly impedes the comprehension of the precise mecha
Externí odkaz:
https://doaj.org/article/824669f56e69431d8fcf04ba6cd6b4d4
Autor:
Timothy S. Luongo, Jonathan P. Lambert, Ancai Yuan, Xueqian Zhang, Polina Gross, Jianliang Song, Santhanam Shanmughapriya, Erhe Gao, Mohit Jain, Steven R. Houser, Walter J. Koch, Joseph Y. Cheung, Muniswamy Madesh, John W. Elrod
Publikováno v:
Cell Reports, Vol 12, Iss 1, Pp 23-34 (2015)
Cardiac contractility is mediated by a variable flux in intracellular calcium (Ca2+), thought to be integrated into mitochondria via the mitochondrial calcium uniporter (MCU) channel to match energetic demand. Here, we examine a conditional, cardiomy
Externí odkaz:
https://doaj.org/article/a56efb7af9a241a9a48dd015464ebe75
Autor:
Rhonda L. Carter, Erin McEachern, Joseph Y. Cheung, Jianliang Song, Ana Maria Lucchese, Erhe Gao, Douglas G. Tilley, Ama Dedo Okyere, Toby P. Thomas, Jonathan A. Kirk, Thomas G Martin, Viren C Patwa, Sudarsan Rajan, Joshua Strong, Melissa Landy, Shuchi Guo, Walter J. Koch
Publikováno v:
Cardiovasc Res
Aims Epidermal growth factor receptor (EGFR) is essential to the development of multiple tissues and organs and is a target of cancer therapeutics. Due to the embryonic lethality of global EGFR deletion and conflicting reports of cardiac-overexpresse
Autor:
Joseph Y. Cheung, Jianliang Song, Kamel Khalili, Arthur M. Feldman, Jennifer Gordon, Xue-Qian Zhang, Dhanendra Tomar, JuFang Wang, Glenn S. Gerhard, Valerie D. Myers
Publikováno v:
J Card Fail
Background We reported 3 novel nonsynonymous single nucleotide variants of Bcl2-associated athanogene 3 (BAG3) in African Americans with heart failure (HF) that are associated with a 2-fold increase in cardiac events (HF hospitalization, heart transp
Autor:
Ama Dedo, Okyere, Jianliang, Song, Viren, Patwa, Rhonda L, Carter, Nitya, Enjamuri, Anna Maria, Lucchese, Jessica, Ibetti, Claudio, de Lucia, Sarah M, Schumacher, Walter J, Koch, Joseph Y, Cheung, Jeffrey L, Benovic, Douglas G, Tilley
Publikováno v:
Cardiovascular drugs and therapy.
β-Adrenergic receptors (βAR) are essential targets for the treatment of heart failure (HF); however, chronic use of βAR agonists as positive inotropes to increase contractility in a GWe measured adult mouse cardiomyocyte contractility in response
Autor:
Muniswamy Madesh, Sudasan Rajan, Santhanam Shanmughapriya, Shey-Shing Sheu, Barbara A. Miller, Xue-Qian Zhang, Iwona Hirschler-Laszkiewicz, Arthur M. Feldman, Jianliang Song, JuFang Wang, Dhanendra Tomar, Joseph Y. Cheung
Publikováno v:
J Cell Physiol
The mechanisms by which Trpm2 channels enhance mitochondrial bioenergetics and protect against oxidative stress-induced cardiac injury remain unclear. Here, the role of proline-rich tyrosine kinase 2 (Pyk2) in Trpm2 signaling is explored. Activation