Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jianjing Xue"'
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50071 (2012)
Profound cardiovascular dysfunction is an important cause of mortality from septic shock. The molecular underpinnings of cardiac dysfunction during the inflammatory surge of early sepsis are not fully understood. MAPKs are important signal transducer
Externí odkaz:
https://doaj.org/article/7c8b78343e1447f59225b5d86b6d1ff0
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 312:L568-L578
Pulmonary artery smooth muscle cell (PASMC) proliferation is one of the hallmark features of hypoxia-induced pulmonary hypertension. With only supportive treatment options available for this life-threatening disease, treating and preventing the proli
Publikováno v:
The FASEB Journal. 33
Autor:
Yasmine Shakibi, Yusen Liu, Pingping Xu, Leif D. Nelin, Lobelia Samavati, Jianjing Xue, Lyn M. Wancket, Sara A. Crowell
Publikováno v:
Journal of Biological Chemistry. 289:28753-28764
MAPK phosphatases (MKPs) are critical modulators of the innate immune response, and yet the mechanisms regulating their accumulation remain poorly understood. In the present studies, we investigated the role of post-translational modification in the
Autor:
Louis G. Chicoine, Xiaomei Meng, Andrea E. Calvert, Jianjing Xue, Jessica Lauren Slutzky, Bernadette Chen
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 307:L317-L325
Pulmonary artery smooth muscle cell (PASMC) proliferation plays a fundamental role in the vascular remodeling seen in pulmonary hypertensive diseases associated with hypoxia. Arginase II, an enzyme regulating the first step in polyamine and proline s
Autor:
Frazier, W. Joshua1,2 (AUTHOR) warren.frazier@nationwidechildrens.org, Jianjing Xue2 (AUTHOR), Luce, Wendy A.1,3 (AUTHOR), Yusen Liu1,2 (AUTHOR)
Publikováno v:
PLoS ONE. Nov2012, Vol. 7 Issue 11, Special section p1-10. 10p.
Autor:
Joshua T. Enneking, Iveta Grants, Helen J. Cooke, Kent C. Williams, Alan Harzman, Jianjing Xue, Andrómeda Liñán-Rico, Wendy L. Frankel, Fievos L. Christofi, Jacqueline E. Wunderlich
Publikováno v:
Inflammatory Bowel Diseases. 19:2366-2379
Alterations in 5-hydroxytryptamine (HT) signaling in inflamed gut may contribute to pathogenesis of inflammatory bowel diseases. Adenosine 5'-triphosphate (ATP) regulates mucosal-mechanosensory reflexes and ATP receptors are sensitive to mucosal infl
Autor:
Yusen Liu, Ranyia Matta, Jing Yan, Jianjing Xue, Jessica L. Grieves, W. Joshua Frazier, Andrew C.B. Cato, Leif D. Nelin, John Barnard, Lyn M. Wancket
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G1322-G1335
Il-10-deficient mice develop colitis associated with exaggerated Th1/Th17 responses and are a valuable model of inflammatory bowel disease. Mkp-1 is a major negative regulator of MAPKs, and its expression is enhanced by IL-10. To understand the role
Autor:
Hong Huang, Juli M. Richter, Peter J. Giannone, Jianjing Xue, John Anthony Bauer, Brandon L. Schanbacher
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 54:639-644
OBJECTIVES Intestinal epithelial restitution is the first part in the process of mucosal repair after injury in the intestine. Integrity of the intestinal mucosal barrier is important as a first line of defense against bacteria and endotoxin. Necroti
Publikováno v:
Neurogastroenterology & Motility. 19:309-317
5-Hydroxytryptamine (5-HT) from enterochromaffin cells activates neural reflexes that govern intestinal motility and secretion. Mechanical stimulation of human enterochromaffin cell-derived BON cells activates a G alpha q-signalling pathway coupled t