Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Jianjian ZHENG"'
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 10, Pp n/a-n/a (2024)
ABSTRACT Background and aims Myofibroblasts, the primary producers of extracellular matrix, primarily originate from hepatic stellate cells (HSCs), and their activation plays a pivotal role in liver fibrosis. This study aimed to investigate the funct
Externí odkaz:
https://doaj.org/article/bdbc2e34c9fe4313bc00d6707a867085
Autor:
Xinmiao Li, Yifei Li, Weizhi Zhang, Feng Jiang, Lifan Lin, Yining Wang, Lingling Wu, Han Zeng, Jianjian Zheng
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 8, Pp n/a-n/a (2024)
ABSTRACT Introduction Liver fibrosis is primarily driven by the activation of hepatic stellate cells (HSCs), which involves various epigenetic modifications. Objectives N6‐methyladenosine (m6A), the most prevalent RNA modification in eukaryotic cel
Externí odkaz:
https://doaj.org/article/c83d0cab21084294b8e5739e79df0388
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was f
Externí odkaz:
https://doaj.org/article/5585681571dd4c89b66f856054484a81
Autor:
Zhenxu Zhou, Rongrong Zhang, Xinmiao Li, Weizhi Zhang, Yating Zhan, Zhichao Lang, Qiqi Tao, Jinglu Yu, Suhui Yu, Zhengping Yu, Jianjian Zheng
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Hepatic stellate cell (HSC) activation is considered as a central driver of liver fibrosis and effective suppression of HSC activation contributes to the treatment of liver fibrosis. Circular RNAs (circRNAs) have been reported to be importan
Externí odkaz:
https://doaj.org/article/e2bc0189bc314c579cbb0ac5115736e3
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 5, Pp 100902- (2024)
Liver fibrosis is primarily driven by the activation of hepatic stellate cells (HSCs), a process associated with ferroptosis. Ginsenoside Rb1 (GRb1), a major active component extracted from Panax ginseng, inhibits HSC activation. However, the potenti
Externí odkaz:
https://doaj.org/article/ab6deddcd7d7446fa65502d7a38560e9
Autor:
Qiqi Tao, Zhichao Lang, Yifei Li, Yuxiang Gao, Lifan Lin, Zhengping Yu, Jianjian Zheng, Suhui Yu
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Necroptosis has been reported to be involved in cancer progression and associated with cancer prognosis. However, the prognostic values of necroptosis-related genes (NRGs) in hepatocellular carcinoma (HCC) remain largely unknown. This study
Externí odkaz:
https://doaj.org/article/a38b2b8e1706401f83f41d8f4ecccfc3
Publikováno v:
Pifu-xingbing zhenliaoxue zazhi, Vol 30, Iss 4, Pp 340-348 (2023)
Objective To identify comorbid hub genes in psoriasis and atherosclerosis. Methods Transcriptomic datasets of three psoriatic samples and three atherosclerosis samples were downloaded from the GEO database. A deep learning algorithm (Batch Normalizat
Externí odkaz:
https://doaj.org/article/841f3300689245b2823ad181725a5634
Autor:
Zhichao Lang, Yifei Li, Lifan Lin, Xinmiao Li, Qiqi Tao, Yuhang Hu, Menglu Bao, Lei Zheng, Zhengping Yu, Jianjian Zheng
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Recently, Salidroside (Sal) has been demonstrated to suppress hepatic stellate cell (HSC) activation, a crucial event for liver fibrosis. Moreover, Sal has been reported to decrease hepatocyte injury. A growing number of reports have indicat
Externí odkaz:
https://doaj.org/article/cde14952e0f8495e9894ea1a041cb3e8
Autor:
Rongrong Zhang, Xinmiao Li, Yuxiang Gao, Qiqi Tao, Zhichao Lang, Yating Zhan, Chunxue Li, Jianjian Zheng
Publikováno v:
Journal of Ginseng Research, Vol 47, Iss 4, Pp 534-542 (2023)
Background: Ginsenoside Rg1, a bioactive component of Ginseng, has demonstrated anti-inflammatory, anti-cancer, and hepatoprotective effects. It is known that the epithelial–mesenchymal transition (EMT) plays a key role in the activation of hepatic
Externí odkaz:
https://doaj.org/article/2c10988ecc9b483d9fcdee4ef1506e09
Publikováno v:
Journal of Ginseng Research, Vol 47, Iss 4, Pp 515-523 (2023)
Background: 20(S)-protopanaxadiol (PPD), one of the main components of ginseng, has anti-inflammatory, anti-estrogenic, and anti-tumor activities. It is known that activated hepatic stellate cells (HSCs) are the primary producers of extracellular mat
Externí odkaz:
https://doaj.org/article/308bd3bac6bf4c209b06e846e41f8475