Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Jianhui Rong"'
Publikováno v:
Acta Materia Medica, Vol 3, Iss 4, Pp 383-404 (2024)
Celastrol is an active compound from the root of Tripterygium wilfordii Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity. However, the clinical application of celastrol has been hind
Externí odkaz:
https://doaj.org/article/c74be31d0efa42988e7b9a5ccc6b9ec3
Autor:
Lingling Zheng, Weiyao Liao, Shan Luo, Bingyu Li, Di Liu, Qingping Yun, Ziyi Zhao, Jia Zhao, Jianhui Rong, Zhiguo Gong, Feng Sha, Jinling Tang
Publikováno v:
EClinicalMedicine, Vol 76, Iss , Pp 102810- (2024)
Summary: Background: Previous conventional epidemiological studies found a J-shape relationship between alcohol consumption and dementia, but this result was subject to confounding biases and reverse causation. Therefore, we aimed to investigate the
Externí odkaz:
https://doaj.org/article/7c364582faaa43acbe9a2f0724f30b47
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Myocardial infarction (MI) is a highly prevalent and lethal disease worldwide. Prevention and timely recovery are critical for the control of the recurrence and heart failure in MI survivors. The present study was designed to investigate the cardiopr
Externí odkaz:
https://doaj.org/article/eb626f42dba44868903453c34097a2cb
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Depression is clinically defined as a mood disorder with persistent feeling of sadness, despair, fatigue, and loss of interest. The pathophysiology of depression is tightly regulated by the biosynthesis, transport and signaling of neurotransmitters [
Externí odkaz:
https://doaj.org/article/8e054eedc4a841d9a945068846a28998
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
ObjectiveTo explore whether the modified Qing’ e Pills (MQEP) exerts anti-osteoporotic effects and prevents bone loss by enhancing angiogenesis.MethodsNetwork pharmacology was used to assess whether MQEP has a pro-angiogenic capacity and to predict
Externí odkaz:
https://doaj.org/article/6d473c5857de42a9be36c58b4e5e03e8
Publikováno v:
Stem Cell Research, Vol 63, Iss , Pp 102859- (2022)
Ras-related GTP-binding protein A (RagA), encoded by RRAGA gene, initially senses the availability of cellular amino acids (e.g., leucine) and controls the translocation of mTORC1 to the lysosomal membrane. RagA overexpression appears to be associate
Externí odkaz:
https://doaj.org/article/bfe433fed1c14dc1a43f98a6207e930a
Autor:
Dan Luo, Ni Fan, Xiuying Zhang, Fung Yin Ngo, Jia Zhao, Wei Zhao, Ming Huang, Ding Li, Yu Wang, Jianhui Rong
Publikováno v:
eLife, Vol 11 (2022)
Targeting endoplasmic reticulum (ER) stress, inflammation, and metabolic dysfunctions may halt the pathogenesis of obesity and thereby reduce the prevalence of diabetes, cardiovascular disesases, and cancers. The present study was designed to elucida
Externí odkaz:
https://doaj.org/article/a66391f1efff43d3ae35d40e46977d91
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Small ubiquitin-like modifier (SUMO) proteins modify proteins through SUMOylation as an essential protein post-translational modification (PTM) for regulating redox status, inflammation, and cardiac fibrosis in myocardial infarction. This
Externí odkaz:
https://doaj.org/article/40c2a679f47d4e4e9181c5801f1e4c94
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Myocardial infarction is a prevalent and life-threatening cardiovascular disease. The main goal of existing interventional therapies is to restore coronary reperfusion while few are designed to ameliorate the pathology of heart diseases via targeting
Externí odkaz:
https://doaj.org/article/d628b6507b2b4cc2b419066393f68c8d
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Bacterial infection is a potential risk factor for depression. However, little is known about the mechanistic link between bacterial endotoxin and depressive-like behaviors. The aim of the present study was to clarify whether lipo
Externí odkaz:
https://doaj.org/article/1b27c0fea9594635ae264e157f00e17f