Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Jianhua Xing"'
Publikováno v:
eLife, Vol 11 (2022)
How a cell changes from one stable phenotype to another one is a fundamental problem in developmental and cell biology. Mathematically, a stable phenotype corresponds to a stable attractor in a generally multi-dimensional state space, which needs to
Externí odkaz:
https://doaj.org/article/38c8f8b1284f43c5932c9770ff091d4b
Autor:
Polakit Teekakirikul, Wenjuan Zhu, George C. Gabriel, Cullen B. Young, Kylia Williams, Lisa J. Martin, Jennifer C. Hill, Tara Richards, Marie Billaud, Julie A. Phillippi, Jianbin Wang, Yijen Wu, Tuantuan Tan, William Devine, Jiuann-huey Lin, Abha S. Bais, Jonathan Klonowski, Anne Moreau de Bellaing, Ankur Saini, Michael X. Wang, Leonid Emerel, Nathan Salamacha, Samuel K. Wyman, Carrie Lee, Hung Sing Li, Anastasia Miron, Jingyu Zhang, Jianhua Xing, Dennis M. McNamara, Erik Fung, Paul Kirshbom, William Mahle, Lazaros K. Kochilas, Yihua He, Vidu Garg, Peter White, Kim L. McBride, D. Woodrow Benson, Thomas G. Gleason, Seema Mital, Cecilia W. Lo
Publikováno v:
HGG Advances, Vol 2, Iss 3, Pp 100037- (2021)
Summary: Bicuspid aortic valve (BAV) with ∼1%–2% prevalence is the most common congenital heart defect (CHD). It frequently results in valve disease and aorta dilation and is a major cause of adult cardiac surgery. BAV is genetically linked to ra
Externí odkaz:
https://doaj.org/article/0b7019f7bd454037bec2471ea5feef8c
Autor:
Xiao-Jun Tian, Dong Zhou, Haiyan Fu, Rong Zhang, Xiaojie Wang, Sui Huang, Youhua Liu, Jianhua Xing
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Tissue fibrosis compromises organ function and occurs as a potential long-term outcome in response to acute tissue injuries. Currently, lack of mechanistic understanding prevents effective prevention and treatment of the progression from acu
Externí odkaz:
https://doaj.org/article/d070aeed62ac462080a34f20ada77735
Autor:
Jungeun Sarah Kwon, Nicholas J. Everetts, Xia Wang, Weikang Wang, Kimiko Della Croce, Jianhua Xing, Guang Yao
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3223-3235 (2017)
Quiescence is a non-proliferative cellular state that is critical to tissue repair and regeneration. Although often described as the G0 phase, quiescence is not a single homogeneous state. As cells remain quiescent for longer durations, they move pro
Externí odkaz:
https://doaj.org/article/384d8d4c54f2412e9904866d6c608482
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 3, p e1006786 (2019)
Many cellular responses to surrounding cues require temporally concerted transcriptional regulation of multiple genes. In prokaryotic cells, a single-input-module motif with one transcription factor regulating multiple target genes can generate coord
Externí odkaz:
https://doaj.org/article/cef0f81613bf46d3b8df94f6901dc7ed
Autor:
Debasish Mondal, Edward Dougherty, Abhishek Mukhopadhyay, Adria Carbo, Guang Yao, Jianhua Xing
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105833 (2014)
A focused theme in systems biology is to uncover design principles of biological networks, that is, how specific network structures yield specific systems properties. For this purpose, we have previously developed a reverse engineering procedure to i
Externí odkaz:
https://doaj.org/article/93d1e4cf7f5940c698eb600c46249e81
Autor:
Yuanjie Hu, Ning Ru, Huasheng Xiao, Abhishek Chaturbedi, Neil T Hoa, Xiao-Jun Tian, Hang Zhang, Chao Ke, Fengrong Yan, Jodi Nelson, Zhenzhi Li, Robert Gramer, Liping Yu, Eric Siegel, Xiaona Zhang, Zhenyu Jia, Martin R Jadus, Charles L Limoli, Mark E Linskey, Jianhua Xing, Yi-Hong Zhou
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80898 (2013)
Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 (Chr7) copy number variation (CNV) in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in g
Externí odkaz:
https://doaj.org/article/16ff723591814f138d5f77f79ce7780b
Publikováno v:
Journal of Clinical Medicine, Vol 5, Iss 4, p 41 (2016)
Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing, and cancer development. It involves cooperation of signaling pathways, such as transformation growth factor-β (TGF-β), Sonic Hedgehog (SHH), and WNT pathways. T
Externí odkaz:
https://doaj.org/article/a106985d004845d4acc2a89d85d46a6b
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34633 (2012)
The neutrophil gelatinase-associated lipocalin 2 (LCN2) is a critical inflammatory mediator persistently induced during endotoxemia, contributing to tubular damage and kidney failure. The intracellular process responsible for persistent induction of
Externí odkaz:
https://doaj.org/article/fcc0969b528841bea4b0985db5f34a61
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 5, p e1002526 (2012)
The innate immune system, acting as the first line of host defense, senses and adapts to foreign challenges through complex intracellular and intercellular signaling networks. Endotoxin tolerance and priming elicited by macrophages are classic exampl
Externí odkaz:
https://doaj.org/article/12788668e02d4a0f8e6cc175860daeb1