Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Jianhan, Chen"'
Autor:
Verena Burtscher, Jonathan Mount, Jian Huang, John Cowgill, Yongchang Chang, Kathleen Bickel, Jianhan Chen, Peng Yuan, Baron Chanda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the automaticity of action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage-gated ion channels, the HCN and
Externí odkaz:
https://doaj.org/article/ed21ec411b92467f8993849f5cda3aa8
Autor:
Jian Huang, Jianhan Chen
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Transmembrane ion channels frequently regulate ion permeation by forming bundle crossing of the pore-lining helices when deactivated. The resulting physical constriction is believed to serve as the de facto gate that imposes the major free e
Externí odkaz:
https://doaj.org/article/c5ced682ce764938bca06c32d3a69e51
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2024)
Transient receptor potential (TRP) channels are a large and diverse family of transmembrane ion channels that are widely expressed, have important physiological roles, and are associated with many human diseases. These proteins are actively pursued a
Externí odkaz:
https://doaj.org/article/0ceefe50e2f2486aae72bb32d21842da
Publikováno v:
Pharmaceutical Fronts, Vol 05, Iss 04, Pp e274-e281 (2023)
With the rapid development of novel photosensitizers/photocatalysts, photochemical transformation has become possible and practical. In this context, we report for the first time our work on testing and quantifying the durability and robustness of a
Externí odkaz:
https://doaj.org/article/69a82030c1f4485184ad3c91b67e820f
Autor:
Guohui Zhang, Xianjin Xu, Zhiguang Jia, Yanyan Geng, Hongwu Liang, Jingyi Shi, Martina Marras, Carlota Abella, Karl L. Magleby, Jonathan R. Silva, Jianhan Chen, Xiaoqin Zou, Jianmin Cui
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Ca2+ activated BK channels are important for neural and muscle function. Here authors use a compound, BC5, to show that the interface between the cytosolic and voltage sensing domains is a major allosteric pathway for Ca2+ binding to open the channel
Externí odkaz:
https://doaj.org/article/67b10c912c5146eda08534fccfe9cc8f
Autor:
Erik Nordquist, Guohui Zhang, Shrishti Barethiya, Nathan Ji, Kelli M White, Lu Han, Zhiguang Jia, Jingyi Shi, Jianmin Cui, Jianhan Chen
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 9, p e1011460 (2023)
Machine learning has played transformative roles in numerous chemical and biophysical problems such as protein folding where large amount of data exists. Nonetheless, many important problems remain challenging for data-driven machine learning approac
Externí odkaz:
https://doaj.org/article/df1b3ec8b0da420e9040b66a6deabfa8
Publikováno v:
Technologies, Vol 12, Iss 3, p 29 (2024)
By planting LEDs on the surfaces of orifice baffles, a novel batch oscillatory baffled photoreactor (OBPR) together with polymer-supported Rose Bengal (Ps-RB) beads are here used to investigate the reaction kinetics of a photo-oxidation reaction betw
Externí odkaz:
https://doaj.org/article/b4e18b5f0d6a4bf6bcf1a64f5e2360d2
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Gram-positive pathogenic bacteria Staphylococcus express and secret staphylococcal peroxidase inhibitor (SPIN) proteins to help evade neutrophil-mediated immunity by inhibiting the activity of the main oxidative-defense player myeloperoxidase (MPO) e
Externí odkaz:
https://doaj.org/article/776a35175b8e4c788083fb7cdacd301f
Publikováno v:
Molecules, Vol 28, Iss 10, p 4047 (2023)
Machine learning has achieved remarkable success across a broad range of scientific and engineering disciplines, particularly its use for predicting native protein structures from sequence information alone. However, biomolecules are inherently dynam
Externí odkaz:
https://doaj.org/article/4287f4b0687644b48e6d2e9e4cbc66f2
Autor:
Jing Zhao, Alan Blayney, Xiaorong Liu, Lauren Gandy, Weihua Jin, Lufeng Yan, Jeung-Hoi Ha, Ashley J. Canning, Michael Connelly, Chao Yang, Xinyue Liu, Yuanyuan Xiao, Michael S. Cosgrove, Sozanne R. Solmaz, Yingkai Zhang, David Ban, Jianhan Chen, Stewart N. Loh, Chunyu Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Epigallocatechin gallate (EGCG) is a catechin flavonoid which induces apoptosis in cancerous cells, but the underlying molecular mechanisms remain poorly understood. Here authors use an interdisciplinary approach to show a direct interaction between
Externí odkaz:
https://doaj.org/article/bfe12496e2674532a1bf41a125983054