Zobrazeno 1 - 10
of 345
pro vyhledávání: '"Jianguo Gu"'
Autor:
Mayank Gautam, Akihiro Yamada, Ayaka I. Yamada, Qinxue Wu, Kim Kridsada, Jennifer Ling, Huasheng Yu, Peter Dong, Minghong Ma, Jianguo Gu, Wenqin Luo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The roles of Aβ low-threshold mechanoreceptors (LTMRs) in transmitting mechanical hyperalgesia and in alleviating chronic pain have been of great interest but remain contentious. Here we utilized intersectional genetic tools, optogenetics,
Externí odkaz:
https://doaj.org/article/2fd595f339d34b82946f520e00f900e0
Autor:
Mayank Gautam, Akihiro Yamada, Ayaka I. Yamada, Qinxue Wu, Kim Kridsada, Jennifer Ling, Huasheng Yu, Peter Dong, Minghong Ma, Jianguo Gu, Wenqin Luo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/74a8b35a713b42599219f318ef611df3
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1752 (2023)
Drug resistance is a major obstacle to successful cancer treatment. Therefore, it is essential to understand the molecular mechanisms underlying drug resistance to develop successful therapeutic strategies. α6β4 integrin confers resistance to apopt
Externí odkaz:
https://doaj.org/article/57208de81f9045238e71e8b04efe69e9
Autor:
Sicong Hou, Xin Hao, Jiajia Li, Siwei Weng, Jiaxin Wang, Tiantian Zhao, Wenqian Li, Xiaolin Hu, Bing Deng, Jianguo Gu, Qinglei Hang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-12 (2022)
Abstract Transmembrane-4 L-six family member-1 (TM4SF1) is a member of the L6 family and functions as a signal transducer to regulate tumor cell behaviors. However, the function and mechanism of TM4SF1 in esophageal squamous cell carcinoma (ESCC) met
Externí odkaz:
https://doaj.org/article/684f67b599294edf988f78ead035a650
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 54, Iss 4, Pp 606-615 (2021)
Background: The humoral immune response is pivotal to protect the host from Salmonella typhimurium (S. typhimurium) infection. Previously, we found that core fucosylation catalyzed by core fucosyltransferase (Fut8) could regulate the immune responses
Externí odkaz:
https://doaj.org/article/54ef93b95e524fac96833a4f32810687
Publikováno v:
Advances in Mechanical Engineering, Vol 14 (2022)
Although bearings have been used in many rotating machineries, the literatures relative to matched bearings are very scarce. The distributions of contact load and contact angle between bearing parts are the key indicators to reflect the operating con
Externí odkaz:
https://doaj.org/article/0af45e5a09a84cf489a367b99ad810fb
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Fucosylation is a common glycan terminal modification, which has been reported to be inhibited by 2-fluorofucose (2FF) both in vivo and in vitro. The present study aimed to investigate the effect of 2FF on acetaminophen (APAP)-induced acute liver inj
Externí odkaz:
https://doaj.org/article/c8315bb2b7274074ba54e786060dcada
Autor:
Mizuki Muranaka, Shinji Takamatsu, Tsunenori Ouchida, Yuri Kanazawa, Jumpei Kondo, Tsutomu Nakagawa, Yuriko Egashira, Koji Fukagawa, Jianguo Gu, Toru Okamoto, Yoshihiro Kamada, Eiji Miyoshi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7037 (2023)
Fucosylated proteins are widely used as biomarkers of cancer and inflammation. Fucosylated alpha-fetoprotein (AFP-L3) is a specific biomarker for hepatocellular carcinoma. We previously showed that increases in serum AFP-L3 levels depend on increased
Externí odkaz:
https://doaj.org/article/ce43b1ef62034f7db1a20686604dc43a
Autor:
Nozomi Hayashiji, Genri Kawahara, Xing Xu, Tomohiko Fukuda, Aurelien Kerever, Jianguo Gu, Yukiko K. Hayashi, Eri Arikawa-Hirasawa
Publikováno v:
Cells, Vol 12, Iss 1, p 144 (2022)
Glycosylation is an important mechanism regulating various biological processes, including intercellular signaling and adhesion. α-1,6-fucosyltransferase (Fut8) belongs to a family of enzymes that determine the terminal structure of glycans. Fut8 is
Externí odkaz:
https://doaj.org/article/c03a7b2976bb440c8089e6f56e9d7d41
Autor:
Jiajia Li, Liyao Peng, Qun Chen, Ziping Ye, Tiantian Zhao, Sicong Hou, Jianguo Gu, Qinglei Hang
Publikováno v:
Cancers, Vol 14, Iss 14, p 3377 (2022)
Pancreatic cancer (PC) is characterized by rapid progression and a high mortality rate. The current treatment is still based on surgical treatment, supplemented by radiotherapy and chemotherapy, and new methods of combining immune and molecular biolo
Externí odkaz:
https://doaj.org/article/7a222d09cea542e4bef11e5bfb5a4b1f