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Akademický článek

The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e97139 (2014)

Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importan

Externí odkaz: https://doaj.org/article/646e9e91d00f42f6a75e558c5e50e7cf

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Akademický článek

Label free fragment screening using surface plasmon resonance as a tool for fragment finding - analyzing parkin, a difficult CNS target.

Autor: Karin Regnström, Jiangli Yan, Lan Nguyen, Kari Callaway, Yanli Yang, Linnea Diep, Weimei Xing, Anirban Adhikari, Paul Beroza, Roy K Hom, Brigit Riley, Don Rudolph, Michael F Jobling, Jeanne Baker, Jennifer Johnston, Andrei Konradi, Michael P Bova, Dean R Artis

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e66879 (2013)

Surface Plasmon Resonance (SPR) is rarely used as a primary High-throughput Screening (HTS) tool in fragment-based approaches. With SPR instruments becoming increasingly high-throughput it is now possible to use SPR as a primary tool for fragment fin

Externí odkaz: https://doaj.org/article/49e73ef974d742cb8de3fc7bf2fab6d1

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Intramolecular Ring-Opening Decomposition of Aryl Azetidines

Autor: Laura A. McAllister, Michael Aaron Brodney, Jane M. Withka, Jiangli Yan, Thomas N. O'Connell, Laurence Philippe, Kevin Ogilvie, Lara C. Czabaniuk, Matthew Frank Brown, Guoyun Bai, Adam M. Gilbert, Daniel P. Uccello, Erik Alphie Lachapelle, Chao Li, Michael J. Shapiro, Christopher Ryan Butler, Romelia Salomon-Ferrer, Jeremy T. Starr

Publikováno v: ACS Med Chem Lett

[Image: see text] The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramolecular ring-opening decomposition via nucleophilic attack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61495fbd8a53cc5202ef7fb9ae427eaa
https://europepmc.org/articles/PMC8521649/

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Cyclic Peptide Design Guided by Residual Dipolar Couplings, J-Couplings, and Intramolecular Hydrogen Bond Analysis

Autor: Jiangli Yan, Armando Navarro-Vázquez, Ye Che, Veerabahu Shanmugasundaram, Dennis P. Anderson, Roberto R. Gil, Chris Limberakis, Michael J. Shapiro, Kathleen A. Farley

Publikováno v: The Journal of Organic Chemistry. 84:4803-4813

Cyclic peptides have long tantalized drug designers with their potential ability to combine the best attributes of antibodies and small molecules. An ideal cyclic peptide drug candidate would be able to recognize a protein surface like an antibody wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76e08fa6c98f7d64a61404810aa89be
https://doi.org/10.1021/acs.joc.8b02811

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Utilizing on- and off-line monitoring tools to follow a kinetic resolution step during flow synthesis

Autor: Brian P. Boscoe, David A. Foley, Chao Li, Usa Reilly, Kathleen A. Farley, Manjinder S. Lall, Dennis P. Anderson, Matthew R. Reese, Jiangli Yan, Mark W. Bundesmann

Publikováno v: Magnetic Resonance in Chemistry. 55:348-354

In situ reaction monitoring tools offer the ability to track the progress of a synthetic reaction in real time to facilitate reaction optimization and provide kinetic/mechanistic insight. Herein, we report the utilization of flow NMR, flow IR, and ot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::440ec09e163636453d0df77b7fd3f647
https://doi.org/10.1002/mrc.4494

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Depletion of Gut-Resident CCR5+ Cells for HIV Cure Strategies

Autor: Jiangli Yan, Paul Casaz, Connie Chen, Keith A. Reimann, Anthony J. Michaels, Kenneth A. Rogers, Dennis J. Hartigan-O'Connor, David Merriam, Francois Villinger, Gema Méndez-Lagares

Publikováno v: AIDS research and human retroviruses, vol 33, iss S1

The HIV reservoir forming at the earliest stages of infection is likely composed of CCR5+ cells, because these cells are the targets of transmissible virus. Restriction of the CCR5+ reservoir, particularly in the gut, may be needed for subsequent cur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fb6dc3f7c421b843b18a86de524fbc
https://europepmc.org/articles/PMC5684671/

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