Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jianghe Deng"'
Autor:
Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and anti
Externí odkaz:
https://doaj.org/article/a0c4424f2eeb46a689586e4828ae7887
Autor:
Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 8: Article number: 16081 (2017); Published: 17 July 2017, Updated: 13 July 2018 The original version of this Article omitted the following from the Acknowledgements: ‘We thank Robert Kirkpatrick for implementing the high throu
Externí odkaz:
https://doaj.org/article/ee8d0f7b2ad14f48b638c180d558c296
Autor:
Jeffrey A. Messer, Yun Ding, Jianghe Deng, Paolo A. Centrella, Todd L. Graybill, Jean Zhang, Patti McCormick, Carl A. Machutta, Robert H. Bates, John Martin, Joël Lelièvre, Quinn Lu, Jingye Zhou, Alfonso Mendoza-Losana, Xiaopeng Bai, Christopher S. Kollmann, David J. Holmes, Keith Rafferty, Christina S. Pao, Christopher C. Arico-Muendel, Heather O’Keefe, Aaron Coffin, Taylor L. Graham, David Barros-Aguirre, Sandy Chang, Christopher P. Davie, Hongwei Qi, Flora S. Sundersingh, Minghui Wang, Karen A. Ingraham, Jing Chai, Thomas O’Keeffe, Juan Wang, Gang Yao, Lluis Ballell, Jianzhong Huang, Anthony E. Choudhry, Bryan W. King, Andrew J. Pope, Ghotas Evindar, Xiaorong Liu, May Fern Toh, Christine Patricia Donahue, Jeffrey W. Gross, Pan F. Chan, Walter P. Johnson, Ruth Lehr, Hongfeng Deng, Kenneth E Lind, Matt S. Steiginga, Jason W. Dodson, Gurdyal S. Besra, Amy N. Taylor, Devan J. Wilkins, Yue Li, Lawrence M. Szewczuk, Svetlana L. Belyanskaya, Genaro S. Scavello, Sharon Sweitzer, Christopher R. Kwiatkowski, Lynn McCloskey, Bing Xia, Enoch Gao, Christopher B. Phelps, David T. Fosbenner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 8: Article number: 16081 (2017); Published: 17 July 2017, Updated: 13 July 2018 The original version of this Article omitted the following from the Acknowledgements: ‘We thank Robert Kirkpatrick for implementing the high throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87eaf46a6638b2650fa3a4f95e4cf2b
https://doi.org/10.1038/ncomms16227
https://doi.org/10.1038/ncomms16227
Autor:
Michael Thomson, Andrew J. Peat, Hamilton D. Dickson, Zhengrong Zhu, Derek J. Parks, Jianghe Deng, Leah Aquilani, Todd L. Graybill, Kenneth E Lind, Jesse D. Keicher, Christopher C. Arico-Muendel, Frank T. Coppo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:3450-3459
To identify novel antivirals to the hepatitis C virus (HCV) NS4B protein, we utilized encoded library technology (ELT), which enables purified proteins not amenable to standard biochemical screening methods to be tested against large combinatorial li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495cd946d28c453d58f931898529c0ef
https://doi.org/10.1128/aac.00070-15
https://doi.org/10.1128/aac.00070-15
Autor:
Ghotas Evindar, Frank T. Coppo, George P. Vlasuk, Eli Schuman, Charles A. Blum, Cheney Mao, Lei Jin, Han Dai, Robert B. Perni, Jianghe Deng, Svetlana L. Belyanskaya, Todd L. Graybill, John W. Cuozzo, Leah Aquilani, Jeremy S. Disch, Cynthia H. Chiu, Siva Lavu, Kenneth E Lind
Publikováno v:
Journal of Medicinal Chemistry. 56:3666-3679
The sirtuins SIRT1, SIRT2, and SIRT3 are NAD(+) dependent deacetylases that are considered potential targets for metabolic, inflammatory, oncologic, and neurodegenerative disorders. Encoded library technology (ELT) was used to affinity screen a 1.2 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d930b58d521e3aa0dbb27bc20c5fe4
https://doi.org/10.1021/jm400204k
https://doi.org/10.1021/jm400204k
Autor:
Todd L. Graybill, John D. Martin, Jason W. Dodson, Hongfeng Deng, Christopher P. Davie, Christopher C. Arico-Muendel, Minghui Wang, Hongwei Qi, Sandy S. Chang, David J. Holmes, Karen A. Ingraham, Kenneth E Lind, Heather O’Keefe, Carl A. Machutta, David Barros-Aguirre, Christine Patricia Donahue, Christina S. Pao, Jeffrey W. Gross, Ghotas Evindar, Jean Zhang, Bing Xia, Juan Wang, Patti McCormick, Xiaorong Liu, Jianzhong Huang, Joël Lelièvre, Quinn Lu, Pan F. Chan, Matt S. Steiginga, Lynn McCloskey, Christopher S. Kollmann, Taylor L. Graham, Xiaopeng Bai, Jing Chai, Yue Li, Walter P. Johnson, Ruth Lehr, Lawrence M. Szewczuk, Jingye Zhou, Lluis Ballell, Genaro S. Scavello, Robert H. Bates, Anthony E. Choudhry, Aaron Coffin, Sharon Sweitzer, Christopher R. Kwiatkowski, Andrew J. Pope, Enoch Gao, Christopher B. Phelps, David T. Fosbenner, Keith Rafferty, Thomas O’Keeffe, Gang Yao, Bryan W. King, Svetlana L. Belyanskaya, May Fern Toh, Gurdyal S. Besra, Amy N. Taylor, Devan J. Wilkins, Alfonso Mendoza-Losana, Paolo A. Centrella, Flora S. Sundersingh, Jeffrey A. Messer, Yun Ding, Jianghe Deng
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins in parallel using DNA-encoded libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd5399c3ed244a244dc84c19085f169
https://pubmed.ncbi.nlm.nih.gov/30004092
https://pubmed.ncbi.nlm.nih.gov/30004092
Autor:
Zining Wu, Sibongile Mataruse, Alex M. Tamburino, Gang Yao, Jeffrey A. Messer, Yun Ding, Jean Zhang, G Joseph Franklin, Jianghe Deng, Todd L. Graybill, Xin Zeng, David D. Wisnoski, Frank T. Coppo, David I. Israel, Genaro S. Scavello, Jennifer Summerfield, Andrew J. Pope, Michael Platchek, Vera Q. Bodmer, Paolo A. Centrella, Jing Chai, Katie L Sargent Bedard
Publikováno v:
ACS combinatorial science. 17(12)
DNA-encoded small-molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, this technology has been used with soluble protein targets that are produced and used in a purified state. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662cc2aa88e33f6c57ffd2c4564e3e69
https://pubmed.ncbi.nlm.nih.gov/26562224
https://pubmed.ncbi.nlm.nih.gov/26562224
Autor:
Gopinathan Anilkumar, Jianghe Deng, Ashwin Rao, Rajesh Goswami, Tianan Fang, M. Brad Nolt, Kavirayani R. Prasad, Yulian Zhang, Bin Yang, Yongzhong Wu, Franklin A. Davis
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 180:1109-1117
Sulfinimine-derived polyfunctionalized chiral building blocks, often prepared in one pot, provide efficient access, with a minimum of chemical manipulation, to enantiopure, multifunctional amine derivatives including piperidines and pyrrolidines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27d1aa22f53136073bf07f0f838f59fa
https://doi.org/10.1080/10426500590910648
https://doi.org/10.1080/10426500590910648
Autor:
Jianghe Deng, Franklin A. Davis
Publikováno v:
Tetrahedron. 60:5111-5115
The efficient asymmetric synthesis of the antifungal pyrrolidine alkaloid (+)-preussin ( 2 ) was accomplished via the stereoselective reduction of a 5-substituted 3-oxo proline. The oxo proline was prepared from an N-sulfinyl δ-amino β-ketoester, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cb8cd1844e5b57d23ac6079b7fac825
https://doi.org/10.1016/j.tet.2004.03.094
https://doi.org/10.1016/j.tet.2004.03.094
Autor:
Hui Qiu, Franklin A. Davis, Jianghe Deng, Yanfeng Zhang, Tokala Ramachandar, Jing Chai, Venkata Velvadapu
Publikováno v:
Tetrahedron Letters. 51:4042-4044
Photolysis of enantiopure N-sulfinyl amines (sulfinamides) in Et2O–MeOH gives amines in good yield without racemization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::538ca97c4b278b334e98b6edfb81ada9
https://doi.org/10.1016/j.tetlet.2010.05.114
https://doi.org/10.1016/j.tetlet.2010.05.114