Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jianghai Zhu"'
Autor:
Shubhra Srivastava, Pablo Miranda, Teresa Giraldez, Jianghai Zhu, Raul E. Cachau, Miguel Holmgren
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
We studied the impact of Ba2+ ions on the function and structure of large conductance potassium (BK) channels. Ion composition has played a crucial role in the physiological studies of BK channels due to their ability to couple ion composition and me
Externí odkaz:
https://doaj.org/article/e6d813425f68489589e83fbf618911b2
Autor:
Srivastava, Shubhra, Miranda, Pablo, Giraldez, Teresa, Jianghai Zhu, Cachau, Raul E., Holmgren, Miguel
Publikováno v:
Frontiers in Molecular Biosciences; 10/1/2024, p01-07, 7p
Autor:
Shubhra Srivastava, Pablo Miranda, Natalia de Val, Teresa Giraldez, Jianghai Zhu, Raul Cachau, Miguel Holmgren
Ba2+ increases open probability and blocks the permeation pathway of BK channels. Here we discuss Cryo-EM structures of BK channels with Ba2+. They reveal that Ba2+ occupies site S3 in the selectivity filter, leading to blockade. Ba2+ are also detect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf190824f73706fa37c53a0e819599d9
https://doi.org/10.1101/2022.06.10.495656
https://doi.org/10.1101/2022.06.10.495656
Autor:
Jessica Hong, Hyung Joon Kwon, Raul Cachau, Catherine Z. Chen, Kevin John Butay, Zhijian Duan, Dan Li, Hua Ren, Tianyuzhou Liang, Jianghai Zhu, Venkata P. Dandey, Negin P. Martin, Dominic Esposito, Uriel Ortega-Rodriguez, Miao Xu, Mario J. Borgnia, Hang Xie, Mitchell Ho
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
With the emergence of SARS-CoV-2 variants, there is urgent need to develop broadly neutralizing antibodies. Here, we isolate two VHH nanobodies (7A3 and 8A2) from dromedary camels by phage display, which have high affinity for the receptor-binding do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e636e30c61a4c268026b9a84ff989da
https://doi.org/10.1073/pnas.2201433119
https://doi.org/10.1073/pnas.2201433119
Autor:
Shubhra Srivastava, Pablo Miranda, Natalia de Val, Teresa Giraldez, Jianghai Zhu, Raul Cachau, Miguel Holmgren
Publikováno v:
Biophysical Journal. 122:387a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fcd26532bc8b1b7bb402c28a9eefea0
https://doi.org/10.1016/j.bpj.2022.11.2118
https://doi.org/10.1016/j.bpj.2022.11.2118
Publikováno v:
Current Opinion in Structural Biology. 58:53-58
Subatomic resolution macromolecular crystallography has been revealing the most fascinating details of macromolecular structures for many years. This most extreme form of macromolecular crystallography is going through rapid changes. A new generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25d617391f59ddb1a6ce1cf9a0a73ea
https://doi.org/10.1016/j.sbi.2019.05.013
https://doi.org/10.1016/j.sbi.2019.05.013
Autor:
Fu-Yang Lin, Jing Li, Yonghua Xie, Jianghai Zhu, Thi Thu Huong Nguyen, Yonghui Zhang, Jieqing Zhu, Timothy A. Springer
Publikováno v:
Cell. 185:3533-3550.e27
Integrins are validated drug targets with six approved therapeutics. However, small-molecule inhibitors to three integrins failed in late-stage clinical trials for chronic indications. Such unfavorable outcomes may in part be caused by partial agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bffc714d4bf212180c7d6713bef4310
https://doi.org/10.1016/j.cell.2022.08.008
https://doi.org/10.1016/j.cell.2022.08.008
Autor:
Hong, Jessica, Hyung Joon Kwon, Raul Cachau, Chen, Catherine Z., Butay, Kevin John, Zhijian Duan, Dan Li, Hua Ren, Tianyuzhou Liang, Jianghai Zhu, Dandey, Venkata P., Martin, Negin P., Esposito, Dominic, Ortega-Rodriguez, Uriel, Miao Xu, Borgnia, Mario J., Hang Xie, Mitchell Ho
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 5/3/2022, Vol. 119 Issue 18, p1-12, 33p
Autor:
Minlong Shi1, Jianghai Zhu1, Rui Wang1, Xing Chen1, Lizhi Mi1, Walz, Thomas2, Springer, Timothy A.1 springer@idi.harvard.edu
Publikováno v:
Nature. 6/16/2011, Vol. 474 Issue 7351, p343-349. 7p. 3 Diagrams, 1 Graph.
Publikováno v:
The Journal of Cell Biology
Crystals soaked with RGD peptides reveal six intermediate conformational states between the closed and higher affinity, fully open state of the integrin αIIbβ3 headpiece.
Carefully soaking crystals with Arg-Gly-Asp (RGD) peptides, we captured
Carefully soaking crystals with Arg-Gly-Asp (RGD) peptides, we captured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fe67a70801257dc4ed7b44f8187500
https://doi.org/10.1083/jcb.201212037
https://doi.org/10.1083/jcb.201212037