Výsledky vyhledávání - "Jiang-Shan Gong"

Akademický článek

Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Endothelial cells (ECs) and bone marrow stromal cells (BMSCs) play crucial roles in supporting hematopoiesis and hematopoietic regeneration. However, whether ECs are a source of BMSCs remains unclear. Here, we evaluate the contribution of en

Externí odkaz: https://doaj.org/article/4e0e17bbb4dc4421b93305f72ce50a9b

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Akademický článek

Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression

Publikováno v: Bone Research, Vol 11, Iss 1, Pp 1-13 (2023)

Abstract Due to increasing morbidity worldwide, fractures are becoming an emerging public health concern. This study aimed to investigate the effect of metformin on the healing of osteoporotic as well as normal fractures. Type H vessels have recently

Externí odkaz: https://doaj.org/article/ec1134f66c5543bf81f160d8dee444a9

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Akademický článek

Aptamer-functionalized hydrogels promote bone healing by selectively recruiting endogenous bone marrow mesenchymal stem cells

Autor: Jiang-Shan Gong, Guo-Qiang Zhu, Yu Zhang, Bei Chen, Yi-Wei Liu, Hong-Ming Li, Ze-Hui He, Jing-Tao Zou, Yu-Xuan Qian, Sheng Zhu, Xin-Yue Hu, Shan-Shan Rao, Jia Cao, Hui Xie, Zhen-Xing Wang, Wei Du

Publikováno v: Materials Today Bio, Vol 23, Iss , Pp 100854- (2023)

Bone regeneration heavily relies on bone marrow mesenchymal stem cells (BMSCs). However, recruiting endogenous BMSCs for in situ bone regeneration remains challenging. In this study, we developed a novel BMSC-aptamer (BMSC-apt) functionalized hydroge

Externí odkaz: https://doaj.org/article/4f854cba5afb403ca62f05bc58c19a5b

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Akademický článek

Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

This study uncovers the role of extracellular vesicles from bone matrix as a messenger in the development of osteoporosis and vascular calcification (calcification paradox) during skeletal aging and menopause by transferring miR-483-5p and miR-2861.

Externí odkaz: https://doaj.org/article/ab6085afb96c4c6ca3fad64ef9bffdb0

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Ångstrom-scale silver particles potently combat SARS-CoV-2 infection by suppressing the ACE2 expression and inflammatory responses

Autor: Yong-Qiang Deng, Zhen-Xing Wang, Xin Liu, Yi-Yi Wang, Qi Chen, Zhao-Long Li, Bai-Song Zheng, Qing Ye, Jiang-Shan Gong, Guo-Qiang Zhu, Tian-Shu Cao, Wei-Yi Situ, Cheng-Feng Qin, Hui Xie, Wen-Yan Zhang

Publikováno v: Journal of Materials Chemistry B. 10:5454-5464

The SARS-CoV-2 pandemic has become a severe global public health event, and the development of protective and therapeutic strategies is urgently needed. Downregulation of angiotensin converting enzyme 2 (ACE2; one of the important SARS-CoV-2 entry re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee9b7b5dd0fad6213845d8e23af6539
https://doi.org/10.1039/d2tb00336h

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Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox

Publikováno v: Nature communications. 13(1)

Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead of osteoblast formation contributes to age- and menopause-related marrow adiposity and osteoporosis. Vascular calcification often occurs with osteoporosis, a cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce18ade72e4273a4df466c7b7a14a3a0
https://pubmed.ncbi.nlm.nih.gov/35304471

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