Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jiang-Hong Gu"'
Publikováno v:
Brain and Behavior, Vol 12, Iss 8, Pp n/a-n/a (2022)
Abstract Introduction The most striking feature of depression is sadness and a loss of interest in activities, which represents a major cause of disability globally. Therefore, it is necessary to identify novel antidepressants for clinical practice.
Externí odkaz:
https://doaj.org/article/f5093b6e99754a0bb1498d21f2c43667
Autor:
Yuan Wang, Jiang-Hong Gu, Ling Liu, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Wei Guan, Xin-Yi Zhao, Ying-Fang Sun, Da-Wei Xu, Bo Jiang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
As a well-known multimodal-acting antidepressant, vortioxetine is thought to aim at several serotonin (5-HT) receptors and the 5-HT transporter. However, recently more and more proteins besides 5-HT are being reported to participate in the antidepres
Externí odkaz:
https://doaj.org/article/dc065ff7d8b646a39507e9e5dcd391dd
Autor:
Yuan Wang, Ling Liu, Jiang-Hong Gu, Cheng-Niu Wang, Wei Guan, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Yan-Mei Chen, Jie Huang, Wei-Yu Li, Tian-Shun Shi, Wei-Jia Chen, Bao-Lun Zhu, Bo Jiang
Elucidating the molecular mechanism underlying the hyperactivity of the hypothalamic–pituitary–adrenal axis during chronic stress is critical for understanding depression and treating depression. The secretion of corticotropin-releasing hormone (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c9e76bd08d9f10abc64da0e65ba13f
https://doi.org/10.21203/rs.3.rs-1932234/v1
https://doi.org/10.21203/rs.3.rs-1932234/v1
Autor:
Jie Huang, Wei Guan, Jiang-Hong Gu, Da-Wei Xu, Yan-Mei Chen, Wen-Qian Tang, Yue Liu, Bo Jiang, Chun-Hui Ji
Publikováno v:
Biochemical pharmacology. 195
Depression is one of the most common psychiatric diseases in the 21st century, while its pathogenesis is not yet fully understood. Currently, besides to the monoaminergic system, the brain-derived neurotrophic factor (BDNF)-cAMP response element-bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803ff79d6b1f4eb9435587a4658b170c
https://pubmed.ncbi.nlm.nih.gov/34774532
https://pubmed.ncbi.nlm.nih.gov/34774532
Publikováno v:
Behavioural brain research. 399
Antidepressants currently used in clinical practice have limitations such as low efficacy, slow onset and various adverse reactions. It has become necessary to develop novel antidepressants beyond monoaminergic drugs. L-701,324 is a potent NMDA recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f60c24eccf7004098c5fa87442d1bd
https://pubmed.ncbi.nlm.nih.gov/33276033
https://pubmed.ncbi.nlm.nih.gov/33276033
Publikováno v:
Neuroscience letters. 742
Depression is one of the most common psychiatric disorders, and there is strong demand for developing novel antidepressants with better efficacy and less adverse effects. 1-Methylnicotinamide (MNA) is a main metabolite of nicotinamide and has been de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2fc50a00d842ee201653a2ccd35a5e
https://pubmed.ncbi.nlm.nih.gov/33248165
https://pubmed.ncbi.nlm.nih.gov/33248165
Autor:
Wen-Qian, Tang, Yue, Liu, Chun-Hui, Ji, Jiang-Hong, Gu, Yan-Mei, Chen, Jie, Huang, Wei, Guan, Da-Wei, Xu, Bo, Jiang
Publikováno v:
Biochemical Pharmacology. 197:114885
As a highly prevalent neuropsychiatric disorder worldwide, the pathophysiology of depression is not yet fully understood and based on multiple factors among which chronic stress is critical. Numerous previous studies have shown the role of central ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd310b6ccfb2d5d9af05e51e0454b1f
https://doi.org/10.1016/j.bcp.2021.114885
https://doi.org/10.1016/j.bcp.2021.114885
Publikováno v:
Inorganic Chemistry Communications. 136:109167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e25680c8c376bd887a0080aa663ec07
https://doi.org/10.1016/j.inoche.2021.109167
https://doi.org/10.1016/j.inoche.2021.109167
Autor:
Jian-Feng Liu, Bo Jiang, Yue Liu, Wei Guan, Jie Huang, Dawei Xu, Jiang-Hong Gu, Wen-Qian Tang, Chun-Hui Ji, Yan-Mei Chen, Chengniu Wang
Publikováno v:
Pharmacological Research. 174:105932
As a widely-known neuropsychiatric disorder, the exact pathogenesis of depression remains elusive. MiRNA-206 (miR-206) is conventionally known as one of the myomiRs and has two forms: miR-206-3p and miR-206-5p. Recently, miR-206 has been demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c256de8b4b6358c6893e36b4ba0e7044
https://doi.org/10.1016/j.phrs.2021.105932
https://doi.org/10.1016/j.phrs.2021.105932