Zobrazeno 1 - 10
of 358
pro vyhledávání: '"Jiang Fan CHEN"'
Autor:
Jun Tian, Yaping Yan, Wang Xi, Rui Zhou, Huifang Lou, Shumin Duan, Jiang Fan Chen, Baorong Zhang
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
The globus pallidus (GP) is emerging as a critical locus of basal ganglia control of motor activity, but the exact role of GABAergic GP neurons remain to be defined. By targeted expression of channelrhodopsin 2 (ChR2) in GABAergic neurons using the V
Externí odkaz:
https://doaj.org/article/fe9c62f52cfd4470935cc42ab3714d26
Autor:
Xiaoting Sun, Liliana Dias, Chenlei Peng, Ziyi Zhang, Haoting Ge, Zejun Wang, Jiayi Jin, Manli Jia, Tao Xu, Wei Guo, Wu Zheng, Yan He, Youru Wu, Xiaohong Cai, Paula Agostinho, Jia Qu, Rodrigo A. Cunha, Xuzhao Zhou, Ruiliang Bai, Jiang-fan Chen
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract The glymphatic-lymphatic system is increasingly recognized as fundamental for the homeostasis of the brain milieu since it defines cerebral spinal fluid flow in the brain parenchyma and eliminates metabolic waste. Animal and human studies ha
Externí odkaz:
https://doaj.org/article/a55ef0fb8dca4bd3a92cadd1aee9aaa5
Publikováno v:
Chinese Journal of Traumatology, Vol 27, Iss 3, Pp 125-133 (2024)
Adenosine exerts its dual functions of homeostasis and neuromodulation in the brain by acting at mainly 2 G-protein coupled receptors, called A1 and A2A receptors. The adenosine A2A receptor (A2AR) antagonists have been clinically pursued for the las
Externí odkaz:
https://doaj.org/article/3c4465de4ebd4fde9be3138af531b784
Publikováno v:
Neurobiology of Disease, Vol 185, Iss , Pp 106229- (2023)
Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-sensitive classes broadly interfere with cognitive processes both under quasi normal and disease conditions. During neurodegenerative illnesses, high concentrations
Externí odkaz:
https://doaj.org/article/4f5d2d9897474878a9b15713caf2cbbb
Autor:
Wu Zheng, Yijia Feng, Zhenhai Zeng, Mengqian Ye, Mengru Wang, Xin Liu, Ping Tang, Huiping Shang, Xiaoting Sun, Xiangxiang Lin, Muran Wang, Zhengzheng Li, Yiyun Weng, Wei Guo, Sergii Vakal, Jiang-fan Chen
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Background Multiple sclerosis (MS) is one of the most common autoimmune disorders characterized by the infiltration of immune cells into the brain and demyelination. The unwanted immunosuppressive side effect of therapeutically successful na
Externí odkaz:
https://doaj.org/article/24f70e097e9e4a248de68f2a47e85da5
Autor:
Hai-Ying Shen, Sadie B. Baer, Raey Gesese, John M. Cook, Landen Weltha, Shayla Q. Coffman, Jie Wu, Jiang-Fan Chen, Ming Gao, Teng Ji
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Adenosinergic activities are suggested to participate in SUDEP pathophysiology; this study aimed to evaluate the adenosine hypothesis of SUDEP and specifically the role of adenosine A2A receptor (A2AR) in the development of a SUDEP mouse model with r
Externí odkaz:
https://doaj.org/article/62822b3a9a4e4690a5e4c3e02f2609c7
Autor:
Elisabete Augusto, Francisco Q. Gonçalves, Joana E. Real, Henrique B. Silva, Daniela Pochmann, Tiago S. Silva, Marco Matos, Nélio Gonçalves, Ângelo R. Tomé, Jiang-Fan Chen, Paula M. Canas, Rodrigo A. Cunha
Publikováno v:
Neurobiology of Disease, Vol 157, Iss , Pp 105441- (2021)
Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A
Externí odkaz:
https://doaj.org/article/218cea5ef5a84400aaea77837c4e90ac
Autor:
Xiangpeng Ren, Jiang-Fan Chen
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by dopaminergic neurodegeneration, motor impairment and non-motor symptoms. Epidemiological and experimental investigations into potential risk factors hav
Externí odkaz:
https://doaj.org/article/bf03de4cfaa74596a6fb3332a334fbfd
The Pharmacological Potential of Adenosine A2A Receptor Antagonists for Treating Parkinson’s Disease
Publikováno v:
Molecules, Vol 27, Iss 7, p 2366 (2022)
The adenosine A2A receptor subtype is recognized as a non-dopaminergic pharmacological target for the treatment of neurodegenerative disorders, notably Parkinson’s disease (PD). The selective A2A receptor antagonist istradefylline is approved in th
Externí odkaz:
https://doaj.org/article/5fac48f488994ae48da8a548382e877e
Autor:
Rong Zhou, Shuya Zhang, Xuejiao Gu, Yuanyuan Ge, Dingjuan Zhong, Yuling Zhou, Lingyun Tang, Xiao-Ling Liu, Jiang-Fan Chen
Publikováno v:
Molecular Medicine, Vol 24, Iss 1, Pp 1-13 (2018)
Abstract Background Retinopathy of prematurity (ROP) remains a major cause of childhood blindness and current laser photocoagulation and anti-VEGF antibody treatments are associated with reduced peripheral vision and possible delayed development of r
Externí odkaz:
https://doaj.org/article/fd39d01e9a8f4981a88b47d65b7f1ad3