Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Jiang‑Jiang Qin"'
Autor:
Xiaoqing Guan, Yichao Wang, Wenkai Yu, Yong Wei, Yang Lu, Enyu Dai, Xiaowu Dong, Bing Zhao, Can Hu, Li Yuan, Xin Luan, Kai Miao, Bonan Chen, Xiang‐Dong Cheng, Weidong Zhang, Jiang‐Jiang Qin
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract Gastric cancer (GC) presents a formidable global health challenge, and conventional therapies face efficacy limitations. Ubiquitin‐specific protease 7 (USP7) plays pivotal roles in GC development, immune response, and chemo‐resistance, m
Externí odkaz:
https://doaj.org/article/309f94baa7be42939e0ccca5ef7af44d
Autor:
Xi Chen, Zhijie Xu, Tongfei Li, Abhimanyu Thakur, Yu Wen, Kui Zhang, Yuanhong Liu, Qiuju Liang, Wangrui Liu, Jiang-Jiang Qin, Yuanliang Yan
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-22 (2024)
Abstract The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing a crucial role in improving antitumor immunity through immune effector responses. Targeting the cGAS-STING pathway holds promise for over
Externí odkaz:
https://doaj.org/article/868c931b3bcf451490afa6ef14e96637
Publikováno v:
Chinese Medicine, Vol 18, Iss 1, Pp 1-23 (2023)
Abstract The pharmacological effects of natural product therapy have received sigificant attention, among which terpenoids such as sesquiterpene lactones stand out due to their biological activity and pharmacological potential as anti-tumor drugs. In
Externí odkaz:
https://doaj.org/article/c77f5fda69684b22b5d482983e9ec598
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Aspergillus fungi are renowned for producing a diverse range of natural products with promising biological activities. These include lovastatin, itaconic acid, terrin, and geodin, known for their cholesterol-regulating, anti-inflammatory, antitumor,
Externí odkaz:
https://doaj.org/article/91596bd236ee42d18692644e721fd281
Autor:
Shengli Li, Li Yuan, Zhi-Yuan Xu, Jing-Li Xu, Gui-Ping Chen, Xiaoqing Guan, Guang-Zhao Pan, Can Hu, Jinyun Dong, Yi-An Du, Li-Tao Yang, Mao-Wei Ni, Rui-Bin Jiang, Xiu Zhu, Hang Lv, Han-Dong Xu, Sheng-Jie Zhang, Jiang-Jiang Qin, Xiang-Dong Cheng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The molecular subtypes of adenocarcinoma of the esophagogastric junction (AEG) remain to be identified. Here, the authors perform proteogenomic characterisation of AEG tumours with paired normal adjacent tissues and suggest three proteomic subtypes a
Externí odkaz:
https://doaj.org/article/8462f76bacab412a96aed2b142c0a420
Autor:
Jinyun Dong, Jing Yang, Wenkai Yu, Haobin Li, Maohua Cai, Jing-Li Xu, Han-Dong Xu, Yun-Fu Shi, Xiaoqing Guan, Xiang‑Dong Cheng, Jiang‑Jiang Qin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2004-2016 (2022)
Gastric cancer remains a significant health burden worldwide. In continuation of our previous study and development of effective small molecules against gastric cancer, a series of benzochalcone analogues involving heterocyclic molecules were synthes
Externí odkaz:
https://doaj.org/article/59f779a14cb74fd68b924c8ac81f8a4e
Autor:
Chunxiao Zhu, Xiaoqing Guan, Xinuo Zhang, Xin Luan, Zhengbo Song, Xiangdong Cheng, Weidong Zhang, Jiang-Jiang Qin
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-19 (2022)
Abstract Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with drugs is challenging because KRAS is considered undruggable due to the lack of cl
Externí odkaz:
https://doaj.org/article/42a2372fb50f4a22aabdb92123d436df
Autor:
Simin Qi, Xiaoqing Guan, Jia Zhang, Dehua Yu, Xuefei Yu, Qinglin Li, Wenjuan Yin, Xiang-Dong Cheng, Weidong Zhang, Jiang-Jiang Qin
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-18 (2022)
Abstract Background Pancreatic cancer is one of the most lethal cancers worldwide. The IAPs function as E3 ubiquitin ligases and contribute to pancreatic cancer initiation, progression, and metastasis. Although IAP-targeted therapies have been develo
Externí odkaz:
https://doaj.org/article/724af697d9fd407d8d9e9c49e0e972b4
Autor:
Xiaoqing Guan, Jing Yang, Weiyi Wang, Bing Zhao, Shiyu Hu, Dehua Yu, Li Yuan, Yunfu Shi, Jingli Xu, Jinyun Dong, Jinxin Wang, Xiang-Dong Cheng, Jiang-Jiang Qin
Publikováno v:
Pharmacological Research, Vol 189, Iss , Pp 106703- (2023)
Gastric cancer remains one of the most common deadly diseases and lacks effective targeted therapies. In the present study, we confirmed that the signal transducer and activator of transcription 3 (STAT3) is highly expressed and associated with a poo
Externí odkaz:
https://doaj.org/article/adc2fcc512a74785968012322cbc1977
Autor:
Qianqian Xu, Guangzhao Pan, Zhonglan Wang, Lingling Wang, Yancheng Tang, Jinyun Dong, Jiang-Jiang Qin
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Platycodin D (PD) is a triterpene saponin extracted from the root of Platycodon grandiflorum. It has been reported to exhibit multiple pharmacological and biological properties. There is substantial evidence to support that PD displays a wide range o
Externí odkaz:
https://doaj.org/article/72ad74ec527442b3898926b9e9cbe0e1