Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Jiang‑Feng Wu"'
The miR-23b/27b/24-1 Cluster Inhibits Hepatic Fibrosis by Inactivating Hepatic Stellate CellsSummary
Autor:
Lin-Yan Wan, Hu Peng, Yi-Ran Ni, Xue-Ping Jiang, Jiao-Jiao Wang, Yan-Qiong Zhang, Lan Ma, Rui Li, Lin Han, Yong Tan, Jun-Ming Li, Wen-Li Cai, Wen-Fang Yuan, Jia-Jie Liang, Lu Huang, Xu Wu, Quan Zhou, Qi-Ni Cheng, Xue Yang, Meng-Yuan Liu, Wen-Bing Ai, Chang-Bai Liu, Hongbing Zhang, Jiang-Feng Wu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1393-1412 (2022)
Background & Aims: Hepatic fibrosis is characterized by hepatic stellate cell (HSC) activation and transdifferentiation-mediated extracellular matrix (ECM) deposition, which both contribute to cirrhosis. However, no antifibrotic regimen is available
Externí odkaz:
https://doaj.org/article/bea4a956fea14e4aa23d9a85599c23b2
Publikováno v:
Annals of Hepatology, Vol 27, Iss 5, Pp 100720- (2022)
Golgi protein 73 (also known as GP73 or GOLPH2) is a transmembrane glycoprotein present in the Golgi apparatus. In diseased states, GP73 is expressed by hepatocytes rather than by bile duct epithelial cells. Many studies have reported that serum GP73
Externí odkaz:
https://doaj.org/article/639ced4e3f5e41d78c3a56b759decb8d
Publikováno v:
Cell & Bioscience, Vol 8, Iss 1, Pp 1-8 (2018)
Abstract Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate gene or protein expression; however, their function in the progression of hepatic fibrosis remains unclear. Hepatic fibrosis is a continuous wound-healing process cau
Externí odkaz:
https://doaj.org/article/864547a491ea4cf8b16dc6786623376a
Publikováno v:
Cell & Bioscience, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Increasing evidence indicates that embryonic stem cell specific microRNAs (miRNAs) play an essential role in the early development of embryo. Among them, the miR-290-295 cluster is the most highly expressed in the mouse embryonic stem cells
Externí odkaz:
https://doaj.org/article/9e80183b7c424835b700cfa4b6eb9392
Publikováno v:
Cell & Bioscience, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The microRNA (miRNA) family consists of several miRNAs which have th
Externí odkaz:
https://doaj.org/article/8fd2925c37c9492485349627aa44c24f
Publikováno v:
Molecules, Vol 20, Iss 11, Pp 20473-20486 (2015)
Vitamin D Receptor (VDR) belongs to the nuclear receptor (NR) superfamily. Whereas the structure of the ligand binding domain (LBD) of VDR has been determined in great detail, the role of its amino acid residues in stabilizing the structure and ligan
Externí odkaz:
https://doaj.org/article/33c8122e1d2340f5a928765795737700
Publikováno v:
Molecules, Vol 20, Iss 7, Pp 12389-12399 (2015)
While the structure of the DNA-binding domain (DBD) of the vitamin D receptor (VDR) has been determined in great detail, the roles of its domains and how to bind the motif of its target genes are still under debate. The VDR DBD consists of two zinc f
Externí odkaz:
https://doaj.org/article/0b8a13f0c4b24e159b7059b2a981848a
Publikováno v:
Human Cell. 36:528-539
E26 transformation specific or E twenty-six (ETS) protein family consists of 28 transcription factors, five of which, named ETS1/2, PU.1, ERG and EHF, are known to involve in the development of liver fibrosis, and are expected to become diagnostic ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c9bf1f27e7b37b15360ea9c449a590
https://doi.org/10.1007/s13577-022-00848-5
https://doi.org/10.1007/s13577-022-00848-5
Autor:
Wen-Fang Yuan, Lin-Yan Wan, Yan-Qiong Zhang, Wen-Bing Ai, Jiang-Feng Wu, Yuan-Mei Zhong, Wen-Li Cai, Hu Peng
Publikováno v:
Cell Biochemistry and Function
G-quadruplexes form folded structures because of tandem repeats of guanine sequences in DNA or RNA. They adopt a variety of conformations, depending on many factors, including the type of loops and cations, the nucleotide strand number, and the main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4c243e413e74748c655f9ef0efb320
http://europepmc.org/articles/PMC7383576
http://europepmc.org/articles/PMC7383576
Publikováno v:
Combinatorial chemistryhigh throughput screening.
Background: Aptamers, consisting of single-stranded DNA or RNA, have secondary and tertiary structures which could bind specifically to target molecules. They are characterized by strong specificity, high affinity, low molecular weight, and low immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec560a7efe7bfc39eaab6e19e613454
https://pubmed.ncbi.nlm.nih.gov/35490432
https://pubmed.ncbi.nlm.nih.gov/35490432