Výsledky vyhledávání - "Jiang, Zhigan"

Akademický článek

Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors

Autor: Liu, Na, Zhong, Hua, Tu, Jie, Jiang, Zhigan, Jiang, Yanjuan, Jiang, Yan, Jiang, Yuanying, Li, Jian, Zhang, Wannian, Wang, Yan, Sheng, Chunquan

Publikováno v: In European Journal of Medicinal Chemistry 1 January 2018 143:1510-1523

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Discovery of a Novel Selective Dual Peroxisome Proliferator-Activated Receptor α/δ Agonist for the Treatment of Primary Biliary Cirrhosis

Autor: Zhuowei Liu, Xing Liu, Jiliang Zhang, Yuan Zhiliang, Chen Shuhui, Wang Jing, Zhang Xiao, Fengxun Guo, Jiang Zhigan, Jianhua Wang, Haiying He, Jian Li, Lijuan Hou, Chaofeng Long, Gong Zhen, Haijun Li, Chen Xiaoxin, Liang Shen, Deming Xu

Publikováno v: ACS Med Chem Lett

[Image: see text] A novel peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist 5c was developed with an EC(50) of 8 nM for PPARα, 5 nM for PPARδ, and >300-fold selectivity against PPARγ (EC(50) = 2939 nM), respectively. Further ADM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25ae916652766966394bb6b056e17db
https://doi.org/10.1021/acsmedchemlett.9b00189

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Correction to 'The Discovery of 3,3′-Spiro[azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection'

Autor: Lai Kunmin, Ya Sun, Chun Yang, Chen Shuhui, Jian Li, Zhengxian Gu, Han Lixia, Liang Shen, Li Guo, Haiying He, Shi Weihua, Tao Zhao, Fusen Lin, Lijuan Hou, Xinsheng Chen, Jiang Zhigan, Zeng Minggao, Fubiao Xiao

A new series of 3,3'-spirocyclic-2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5f20085986bbd96e26b42aeae33976
https://europepmc.org/articles/PMC5900325/

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Akademický článek

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Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors

Autor: Chunquan Sheng, Yan Jiang, Jie Tu, Na Liu, Wannian Zhang, Hua Zhong, Yanjuan Jiang, Yan Wang, Jiang Zhigan, Yuan-Ying Jiang, Jian Li

Publikováno v: European journal of medicinal chemistry. 143

Lack of novel antifungal agents and severe drug resistance have led to high incidence and associated mortality of invasive fungal infections. To tackle the challenges, novel antifungal agents with new chemotype, fungicidal activity and anti-resistant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370ee87d0e83ebf783ad45756d597c12
https://pubmed.ncbi.nlm.nih.gov/29126739

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Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement

Autor: Jianzhong Yao, Chunquan Sheng, Guoqiang Dong, Yang Liu, Yan Wang, Wenya Wang, Shengzheng Wang, Jiang Zhigan, Bo Xu, Zhenyuan Miao, Guorong Fan, Wannian Zhang

Publikováno v: European Journal of Medicinal Chemistry. 64:16-22

On the basis of our previously discovered triazole antifungal lead compounds, heterocycle-benzene bioisosteric replacement was used to improve their pharmacokinetic profile. The designed new triazole derivatives have good antifungal activity toward a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afebe67daf96c678f6d536a81226195c
https://doi.org/10.1016/j.ejmech.2013.04.025

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