Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

Autor: Yan, Chengsong, Zheng, Lin, Jiang, Shutan, Yang, Haochen, Guo, Jun, Jiang, Lu-yi, Li, Tongzhou, Zhang, Haosong, Bai, Yibing, Lou, Yu, Zhang, Qi, Liang, Tingbo, Schamel, Wolfgang, Wang, Haopeng, Yang, Weiwei, Wang, Guangchuan, Zhu, Zheng-jiang, Song, Bao-Liang, Xu, Chenqi

Publikováno v: In Cancer Cell 10 July 2023 41(7):1276-1293

Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy

Autor: Li, Wentao, Qiu, Shizhen, Chen, Jian, Jiang, Shutan, Chen, Wendong, Jiang, Jingwei, Wang, Fei, Si, Wen, Shu, Yilai, Wei, Ping, Fan, Gaofeng, Tian, Ruijun, Wu, Haitao, Xu, Chenqi, Wang, Haopeng

Publikováno v: In Immunity 18 August 2020 53(2):456-470

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Publisher Correction: Cytoplasmic FBXO38 mediates PD-1 degradation.

Autor: Liu X; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China., Meng X; Advanced Medical Research Institute, Meili Lake Translational Research Park, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China., Lin Z; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China., Jiang S; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China., Liu H; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China., Sun SC; Institute of Immunology, Chinese Institutes for Medical Research, Beijing, China., Liu X; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China., Zhou P; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Huang X; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai, 200032, China.; Shanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai, 200032, China., Wei L; Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510000, China., Yang W; Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Xu C; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China. cqxu@sibcb.ac.cn.; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China. cqxu@sibcb.ac.cn.

Publikováno v: EMBO reports [EMBO Rep] 2024 Nov 01. Date of Electronic Publication: 2024 Nov 01.