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Akademický článek

Repeated Sevoflurane Exposure in Neonatal Rats Enhances the Sensitivity to Pain and Traumatic Stress Later in Juvenile Life

Autor: Chen BZ, Jiang LH, Zhou W, Shang YC, Li F, Liu B

Publikováno v: Journal of Pain Research, Vol Volume 15, Pp 3171-3178 (2022)

Ben-Zhen Chen,1,2,* Li-Hua Jiang,3,* Wenqin Zhou,4 Yu-Chao Shang,4 Fang Li,1 Bin Liu1 1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Anesthesiology, Sichuan Provin

Externí odkaz: https://doaj.org/article/71bcc65598c94e1f9ad5456c4e5d1f15

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A critical role of the transient receptor potential melastatin 2 channel in a positive feedback mechanism for reactive oxygen species‐induced delayed cell death

Autor: Li, X, Jiang, LH

Transient receptor potential melastatin 2 (TRPM2) channel activation by reactive oxygen species (ROS) plays a critical role in delayed neuronal cell death, responsible for postischemia brain damage via altering intracellular Zn2+ homeostasis, but a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::4001244874425d4c40804999c1b06d13

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CRISPR/Cas9-mediated editing of GABRR2 gene in RGC-5 cells induces random exon deletion, exon splicing and new exon recruitment

Autor: Li, C, Fu, Z, Yang, Y, Yan, J, Liu, F, Zhao, W, Zhang, L, Wei, L, Feng, Z, Li, D, Jiang, LH

CRISPR/Cas9 and its variations provide an efficient tool for targeted genome editing. CRISPR/Cas9-based genome editing can induce mutations in genome that has high probability to cause exon truncation or deletion. However, screening mutations in dipl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3f1bdda98cf5d5991b42b203723f47b2

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ATP-activated P2X7 receptor in the pathophysiology of mood disorders and as an emerging target for the development of novel antidepressant therapeutics

Autor: Wei, L, Syed Mortadza, SA, Yan, J, Zhang, L, Wang, L, Yin, Y, Li, C, Chalon, S, Emond, P, Belzung, C, Li, D, Lu, C, Roger, S, Jiang, LH

Mood disorders are a group of psychiatric conditions that represent leading global disease burdens. Increasing evidence from clinical and preclinical studies supports that innate immune system dysfunction plays an important part in the pathophysiolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::57c31a7c9316da390edfd77863cda5ee

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Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and death cell in microglial cells

Autor: Syed Mortadza, S, Sim, JA, Stacey, M, Jiang, LH

Excessive Zn2+ causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H2O2/Zn2+-induced Ca2+ signalling and cell death in microglial cells. H2O2/Zn2+ induced concentration-dependent increases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::895d2ba6c4c9f80506bae229e8670341
https://eprints.whiterose.ac.uk/113628/7/srep45032.pdf

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P2X receptor-mediated ATP purinergic signaling in health and disease

Autor: Jiang LH

Publikováno v: Cell Health and Cytoskeleton, Vol 2012, Iss default, Pp 83-101 (2012)

Lin-Hua JiangSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United KingdomAbstract: Purinergic P2X receptors are plasma membrane proteins present in a wide range of mammalian cells where they act as a cellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::5b93823171758c97596761cdc61b5f5e
http://www.dovepress.com/p2x-receptor-mediated-atp-purinergic-signaling-in-health-and-disease-a11042

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Meta-analysis of epidemiological studies of association of P53 codon 72 polymorphism with bladder cancer

Autor: Yuelong Wang, Jiang Lh, Li Db, Fei Xu, Xiawei Wei

Publikováno v: Genetics and Molecular Research. 9:1599-1605

Although there have been many studies investigating a possible association between p53 codon 72 polymorphism and risk of bladder cancer, the results have been inconsistent. We conducted a meta-analysis of six epidemiological studies, which included 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a31c75d6944436fa600c28250401158
https://doi.org/10.4238/vol9-3gmr882

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Changes in Holdridge Life Zone diversity in the Xinjiang Uygur Autonomous Region (XUAR) of China over the past 40 years

Autor: Yuanrun Zheng, Jiang Lh, Hideyuki Shimizu, Zhixiao Xie, Sam Drake

Publikováno v: Journal of Arid Environments. 66:113-126

The Holdridge Life Zone model, Shannon's Entropy Index and Simpson's Diversity Index were used to study the dynamics of vegetation distribution over the past 40 years in the Xinjiang Uygur Autonomous Region (XUAR), China. The results indicated that H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1a8b08a8307071e0c30b784f5f6568b
https://doi.org/10.1016/j.jaridenv.2005.09.005

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