Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure:javascript:void(0);

Autor: Ruiz-velasco, Andrea, Zi, Min, Hille, Susanne S, Azam, Tayyiba, Kaur, Namrita, Jiang, Juwei, Nguyen, Binh, Sekeres, Karolina, Binder, Pablo, Collins, Lucy, Pu, Fay, Xiao, Han, Guan, Kaomei, Frey, Norbert, Cartwright, Elizabeth J, Müller, Oliver J, Wang, Xin, Liu, Wei

Publikováno v: Ruiz-velasco, A, Zi, M, Hille, S S, Azam, T, Kaur, N, Jiang, J, Nguyen, B, Sekeres, K, Binder, P, Collins, L, Pu, F, Xiao, H, Guan, K, Frey, N, Cartwright, E J, Müller, O J, Wang, X & Liu, W 2020, ' Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure : javascript:void(0); ', eLife, vol. 9 . https://doi.org/10.7554/eLife.54298, https://doi.org/10.7554/eLife.54298

Myocardial insulin resistance contributes to heart failure in response to pathological stresses, therefore, a therapeutic strategy to maintain cardiac insulin pathways requires further investigation. We demonstrated that insulin receptor substrate 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::873aa4bbef3999b9726ec174eef42bb2
https://elifesciences.org/articles/54298

Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure.

Autor: Ruiz-Velasco A; Faculty of Biology, Medicine, and Health, the University of Manchester, Manchester, United Kingdom., Zi M; Faculty of Biology, Medicine, and Health, the University of Manchester, Manchester, United Kingdom., Hille SS; Department of Internal Medicine III, University of Kiel, Kiel, Germany.; DZHK, German Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Kiel, Germany., Azam T; Faculty of Biology, Medicine, and Health, the University of Manchester, Manchester, United Kingdom., Kaur N; Faculty of Biology, Medicine, and Health, the University of Manchester, Manchester, United Kingdom., Jiang J; Faculty of Biology, Medicine, and Health, the University of Manchester, Manchester, United Kingdom., Nguyen B; Faculty of Biology, Medicine, and Health, the University of Manchester, Manchester, United Kingdom., Sekeres K; Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden, Germany., Binder P; Faculty of Biology, Medicine, and Health, the University of Manchester, Manchester, United Kingdom., Collins L; Faculty of Biology, Medicine, and Health, the University of Manchester, Manchester, United Kingdom., Pu F; Edinburgh University Medical School, Edinburgh, United Kingdom., Xiao H; Institute of Vascular Medicine, Peking University, Beijing, China., Guan K; Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technische Universitaet Dresden, Dresden, Germany., Frey N; Department of Internal Medicine III, University of Kiel, Kiel, Germany.; DZHK, German Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Kiel, Germany., Cartwright EJ; Faculty of Biology, Medicine, and Health, the University of Manchester, Manchester, United Kingdom., Müller OJ; Department of Internal Medicine III, University of Kiel, Kiel, Germany.; DZHK, German Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Kiel, Germany., Wang X; Faculty of Biology, Medicine, and Health, the University of Manchester, Manchester, United Kingdom., Liu W; Faculty of Biology, Medicine, and Health, the University of Manchester, Manchester, United Kingdom.

Publikováno v: ELife [Elife] 2020 Mar 30; Vol. 9. Date of Electronic Publication: 2020 Mar 30.