Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jianfei Chao"'
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108037- (2023)
Summary: Myelin defects cause a collection of myelin disorders in the brain. The lack of human models has limited us from better understanding pathological mechanisms of myelin diseases. While human induced pluripotent stem cell (hiPSC)-derived spher
Externí odkaz:
https://doaj.org/article/6bd58f4442264623a67d312af92d735e
Autor:
Lizhao Feng, Jianfei Chao, Peng Ye, Qui Luong, Guoqiang Sun, Wei Liu, Qi Cui, Sergio Flores, Natasha Jackson, Afm Nazmul Hoque Shayento, Guihua Sun, Zhenqing Liu, Weidong Hu, Yanhong Shi
Publikováno v:
Advanced Science, Vol 10, Iss 23, Pp n/a-n/a (2023)
Abstract Demyelinating disorders are among the most common and debilitating diseases in neurology. Canavan disease (CD) is a lethal demyelinating disease caused by mutation of the aspartoacylase (ASPA) gene, which leads to the accumulation of its sub
Externí odkaz:
https://doaj.org/article/09dd6e46f2554eef892a2a30ee48afbe
Autor:
Zhenqing Liu, Jianfei Chao, Cheng Wang, Guihua Sun, Daniel Roeth, Wei Liu, Xianwei Chen, Li Li, E Tian, Lizhao Feng, Hayk Davtyan, Mathew Blurton-Jones, Markus Kalkum, Yanhong Shi
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112841- (2023)
Summary: The C allele of rs11136000 variant in the clusterin (CLU) gene represents the third strongest known genetic risk factor for late-onset Alzheimer’s disease. However, whether this single-nucleotide polymorphism (SNP) is functional and what t
Externí odkaz:
https://doaj.org/article/77cf8d20e7704cc4ab9715b8179a709d
Autor:
Jianfei Chao, Lizhao Feng, Peng Ye, Xianwei Chen, Qi Cui, Guihua Sun, Tao Zhou, E Tian, Wendong Li, Weidong Hu, Arthur D. Riggs, Reuben Matalon, Yanhong Shi
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104391- (2022)
Summary: Canavan disease (CD) is a devastating neurological disease that lacks effective therapy. Because CD is caused by mutations of the aspartoacylase (ASPA) gene, we introduced the wild-type (WT) ASPA gene into patient iPSCs through lentiviral tr
Externí odkaz:
https://doaj.org/article/ec108dc0d5d644b9b0f6d2a356457de6
Autor:
E Tian, Guoqiang Sun, Guihua Sun, Jianfei Chao, Peng Ye, Charles Warden, Arthur D. Riggs, Yanhong Shi
Publikováno v:
Cell Reports, Vol 16, Iss 3, Pp 781-792 (2016)
Growing evidence indicates important roles for astrocytes in neurodevelopment and diseases. However, astrocytes and their roles in these processes remain poorly understood. Despite recent progress in reprogramming somatic cells into different types o
Externí odkaz:
https://doaj.org/article/80d2945396f4480fb41d01a2b3d8f7ec
14-day toxicity study from The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA
Autor:
Linda H. Malkas, David Horne, Karen L. Reckamp, Yanhong Shi, Timothy W. Synold, Steven L. Vonderfecht, Yuan Chen, Yate-Ching Yuan, Jeremy M. Stark, Robert J. Hickey, Hongzhi Li, Weidong Hu, Jianfei Chao, Qi Cui, Emily Sun, Fumiko Yakushijin, Robert Lingeman, Long Gu
Supplementary report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10728ab40fe71dad0973177f6a22d6ee
https://doi.org/10.1158/1078-0432.22469433
https://doi.org/10.1158/1078-0432.22469433
Autor:
Linda H. Malkas, David Horne, Karen L. Reckamp, Yanhong Shi, Timothy W. Synold, Steven L. Vonderfecht, Yuan Chen, Yate-Ching Yuan, Jeremy M. Stark, Robert J. Hickey, Hongzhi Li, Weidong Hu, Jianfei Chao, Qi Cui, Emily Sun, Fumiko Yakushijin, Robert Lingeman, Long Gu
Purpose:Proliferating cell nuclear antigen (PCNA) plays an essential role in regulating DNA synthesis and repair and is indispensable to cancer cell growth and survival. We previously reported a novel cancer associated PCNA isoform (dubbed caPCNA), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77302088a500d8ef947ebbbb547ea4f3
https://doi.org/10.1158/1078-0432.c.6527253.v1
https://doi.org/10.1158/1078-0432.c.6527253.v1
Autor:
Linda H. Malkas, David Horne, Karen L. Reckamp, Yanhong Shi, Timothy W. Synold, Steven L. Vonderfecht, Yuan Chen, Yate-Ching Yuan, Jeremy M. Stark, Robert J. Hickey, Hongzhi Li, Weidong Hu, Jianfei Chao, Qi Cui, Emily Sun, Fumiko Yakushijin, Robert Lingeman, Long Gu
Supplementary Figures Supplemental figure legend: Figure S1. A diagram illustrating the process of virtual screen and follow-up cellular assays used in compound triage. The virtual screen by the computer modeling programs, MOE and Glide, is based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5338a997cb5fbeb2e331394aeb6da7f8
https://doi.org/10.1158/1078-0432.22469424.v1
https://doi.org/10.1158/1078-0432.22469424.v1
Autor:
Linda H. Malkas, David Horne, Karen L. Reckamp, Yanhong Shi, Timothy W. Synold, Steven L. Vonderfecht, Yuan Chen, Yate-Ching Yuan, Jeremy M. Stark, Robert J. Hickey, Hongzhi Li, Weidong Hu, Jianfei Chao, Qi Cui, Emily Sun, Fumiko Yakushijin, Robert Lingeman, Long Gu
Figure Legends Supplemental figure legend: Figure S1. A diagram illustrating the process of virtual screen and follow-up cellular assays used in compound triage. The virtual screen by the computer modeling programs, MOE and Glide, is based on the kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b2f2ba94d498df8cb830d5fc26ebff
https://doi.org/10.1158/1078-0432.22469430
https://doi.org/10.1158/1078-0432.22469430
Autor:
Zhenhua Chen, Keren Zhou, Jianhuang Xue, Andrew Small, Gang Xiao, Le Xuan Truong Nguyen, Zheng Zhang, Emily Prince, Hengyou Weng, Huilin Huang, Zhicong Zhao, Ying Qing, Chao Shen, Wei Li, Li Han, Brandon Tan, Rui Su, Hanjun Qin, Yangchan Li, Dong Wu, Zhaohui Gu, Vu N. Ngo, Xin He, Jianfei Chao, Keith Leung, Kitty Wang, Lei Dong, Xi Qin, Zhenming Cai, Yue Sheng, Yu Chen, Xiwei Wu, Bin Zhang, Yanhong Shi, Guido Marcucci, Zhijian Qian, Mingjiang Xu, Markus Müschen, Jianjun Chen, Xiaolan Deng
Publikováno v:
Blood. 140:998-1000
Although the overall survival rate of B cell acute lymphoblastic leukemia (B-ALL) in childhood is more than 80%, it is merely 30% in refractory/relapsed and adult patients with B-ALL. This demonstrates a need for improved therapy targeting this subgr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2fe3372a6e032c934d0ca93cddcc201
https://doi.org/10.1182/blood-2022-165469
https://doi.org/10.1182/blood-2022-165469