Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jianchen Yu"'
Autor:
Han Tian, Chenying Liu, Jianchen Yu, Jian Han, Jianan Du, Shujun Liang, Wenting Wang, Qin Liu, Rong Lian, Ting Zhu, Shanshan Wu, Tianyu Tao, Yaokai Ye, Jingjing Zhao, Yi Yang, Xun Zhu, Junchao Cai, Jueheng Wu, Mengfeng Li
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-20 (2023)
Abstract Aberrant activation of TGF-β signaling plays a pivotal role in cancer metastasis and progression. However, molecular mechanisms underlying the dysregulation of TGF-β pathway remain to be understood. Here, we found that SMAD7, a direct down
Externí odkaz:
https://doaj.org/article/bf1036375c6445bbb8ae91fe7fc6c04f
Autor:
Kexin Zhang, Jingyao Liang, Bingzhi Zhang, Lishan Huang, Jianchen Yu, Xuhan Xiao, Zhenjian He, Huaming Tao, Jie Yuan
Publikováno v:
Molecules, Vol 29, Iss 5, p 978 (2024)
The Zika virus (ZIKV) is a mosquito-borne virus that already poses a danger to worldwide human health. Patients infected with ZIKV generally have mild symptoms like a low-grade fever and joint pain. However, severe symptoms can also occur, such as Gu
Externí odkaz:
https://doaj.org/article/255e14b89a964a74b9c4c0f894b1f61b
Autor:
Bingzhi Zhang, Jianchen Yu, Ge Zhu, Yun Huang, Kexin Zhang, Xuhan Xiao, Wenxuan He, Jie Yuan, Xiaoxia Gao
Publikováno v:
Molecules, Vol 28, Iss 24, p 8142 (2023)
Zika virus (ZIKV) belongs to the Flavivirus genus of the Flaviviridae family, and is a pathogen posing a significant threat to human health. Currently, there is a lack of internationally approved antiviral drugs for the treatment of ZIKV infection, a
Externí odkaz:
https://doaj.org/article/7abe31dbe22b4f038d5f3611b37ab788
Autor:
Yun Huang, Hongmei Yan, Bingzhi Zhang, Ge Zhu, Jianchen Yu, Xuhan Xiao, Wenxuan He, Yan Chen, Xiaoxia Gao, Zhigang She, Mengfeng Li, Jie Yuan
Publikováno v:
Marine Drugs, Vol 21, Iss 12, p 600 (2023)
Ascomylactam C (AsC) is a new 13-membered-ring macrocyclic alkaloid, which was first isolated and identified in 2019 from the secondary metabolites of the mangrove endophytic fungus Didymella sp. CYSK-4 in the South China Sea. AsC has been found to h
Externí odkaz:
https://doaj.org/article/ef03315990e1441da42aa5b5fc25be52
Publikováno v:
Marine Drugs, Vol 21, Iss 8, p 442 (2023)
Three new dimeric sorbicillinoids (1–3) and one new 3,4,6-trisubstituted α-pyrone (5), along with seven analogues (4 and 6–11), were isolated from the mangrove endophytic fungus Trichoderma reesei SCNU-F0042 under the guidance of molecular netwo
Externí odkaz:
https://doaj.org/article/9fe09aff27b84aa49fb91b0a32dedf1d
Publikováno v:
Viruses, Vol 15, Iss 5, p 1068 (2023)
Zika virus (ZIKV), belonging to the Flavivirus family and mainly transmitted by mosquitoes, causes a variety of adverse outcomes, including Guillain-Barré syndrome, microcephaly, and meningoencephalitis. However, there are no approved vaccines or dr
Externí odkaz:
https://doaj.org/article/f6072263762f4c148ed1c427be0b7305
Autor:
Jie Yuan, Jianchen Yu, Yun Huang, Zhenjian He, Jia Luo, Yun Wu, Yingchun Zheng, Jueheng Wu, Xun Zhu, Haihe Wang, Mengfeng Li
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Zika virus (ZIKV) infection is a global health problem, and its complications, including congenital Zika syndrome and Guillain-Barré syndrome, constitute a continued threat to humans. Unfortunately, effective therapeutics against
Externí odkaz:
https://doaj.org/article/1025291a14314950bfa7cffe2e15e366
Autor:
Yiwen Hu, Jiahui Chen, Guping Hu, Jianchen Yu, Xun Zhu, Yongcheng Lin, Shengping Chen, Jie Yuan
Publikováno v:
Marine Drugs, Vol 13, Iss 1, Pp 202-221 (2015)
Every year, hundreds of new compounds are discovered from the metabolites of marine organisms. Finding new and useful compounds is one of the crucial drivers for this field of research. Here we describe the statistics of bioactive compounds discovere
Externí odkaz:
https://doaj.org/article/4f1dd181e194403ab7d3b9e923019a7f
Autor:
Xun Zhu, Zhenjian He, Yiwen Hu, Weitao Wen, Cuiji Lin, Jianchen Yu, Jing Pan, Ran Li, Haijing Deng, Shaowei Liao, Jie Yuan, Jueheng Wu, Jun Li, Mengfeng Li
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e3088 (2014)
MicroRNAs have been shown to contribute to a repertoire of host-pathogen interactions during viral infection. Our previous study demonstrated that microRNA-30e* (miR-30e*) directly targeted the IκBα 3'-UTR and disrupted the NF-κB/IκBα negative f
Externí odkaz:
https://doaj.org/article/5ffd630f737242c3990cdac984c693d5
Autor:
Jie Yuan, Xun Zhu, Hengming Ye, Zhenjian He, Shuqing Zhang, Jueheng Wu, Yun Wu, Shu An, Mengfeng Li, Chen Jiahui, Jianchen Yu, Tan Chahui
Publikováno v:
Proc Natl Acad Sci U S A
Mounting evidence has associated Zika virus (ZIKV) infection with congenital malformations, including microcephaly, which raises global alarm. Nonetheless, mechanisms by which ZIKV disrupts neurogenesis and causes microcephaly are far from being unde