Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jianbo Dong"'
Autor:
Allison Titong, Sachith Gallolu Kankanamalage, Jianbo Dong, Betty Huang, Nicholas Spadoni, Bo Wang, Meredith Wright, Keegan L. J. Pham, Anh Hai Le, Yue Liu
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract SARS-CoV-2 and its variants have persisted in this ongoing COVID-19 pandemic. While the vaccines have greatly reduced the COVID-19 cases, hospitalizations, and death, about half of the world remain unvaccinated due to various reasons. Furthe
Externí odkaz:
https://doaj.org/article/3cb05b89ba1b49588872e1bb988b0b23
Autor:
Jianbo Dong, Betty Huang, Zhejun Jia, Bo Wang, Sachith Gallolu Kankanamalage, Allison Titong, Yue Liu
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 1034-1036 (2020)
ABSTRACTCoronaviruses cause severe human viral diseases including SARS, MERS and COVID-19. Most recently SARS-CoV-2 virus (causing COVID-19) has led to a pandemic with no successful therapeutics. The SARS-CoV-2 infection relies on trimeric spike (S)
Externí odkaz:
https://doaj.org/article/2e5e3c37b9104662bf2624a2e5a3b6be
Publikováno v:
Atmosphere, Vol 13, Iss 8, p 1188 (2022)
The Beijing–Tianjin–Hebei region is the most dynamic region and largest economy in northern China; however, the air quality is the worst in the country. The study of the air quality in the cities around Beijing is of great significance for air po
Externí odkaz:
https://doaj.org/article/4565c197089540938e897424bfbfbb3f
Autor:
Consuelo Garcia-Rodriguez, Shude Yan, Isin N. Geren, Kristeene A. Knopp, Jianbo Dong, Zhengda Sun, Jianlong Lou, Fraser Conrad, Wei-Hua Wen, Shauna Farr-Jones, Theresa J. Smith, Jennifer L. Brown, Janet C. Skerry, Leonard A. Smith, James D. Marks
Publikováno v:
Toxins, Vol 13, Iss 9, p 641 (2021)
Human botulism can be caused by botulinum neurotoxin (BoNT) serotypes A to G. Here, we present an antibody-based antitoxin composed of four human monoclonal antibodies (mAbs) against BoNT/C, BoNT/D, and their mosaic toxins. This work built on our suc
Externí odkaz:
https://doaj.org/article/a25047536f784a189fd6ca0fc69595fc
Autor:
Jianbo Dong, Betty Huang, Bo Wang, Allison Titong, Sachith Gallolu Kankanamalage, Zhejun Jia, Meredith Wright, Pannaga Parthasarathy, Yue Liu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/c7504889cf7242c099524d8e63f1fa4c
Autor:
Yongfeng Fan, Jianbo Dong, Jianlong Lou, Weihua Wen, Fraser Conrad, Isin N. Geren, Consuelo Garcia-Rodriguez, Theresa J. Smith, Leonard A. Smith, Mengfei Ho, Melissa Pires-Alves, Brenda A. Wilson, James D. Marks
Publikováno v:
Toxins, Vol 7, Iss 9, Pp 3405-3423 (2015)
Existing antibodies (Abs) used to treat botulism cannot enter the cytosol of neurons and bind to botulinum neurotoxin (BoNT) at its site of action, and thus cannot reverse paralysis. However, Abs targeting the proteolytic domain of the toxin could in
Externí odkaz:
https://doaj.org/article/6b1b373bea8b45a2adb6651086bec8a0
Autor:
Jianlong Lou, Weihua Wen, Fraser Conrad, Qi Meng, Jianbo Dong, Zhengda Sun, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, Luisa W. Cheng, Thomas D. Henderson, Jennifer L. Brown, Theresa J. Smith, Leonard A. Smith, Anthony Cormier, James D. Marks
Publikováno v:
Toxins, Vol 10, Iss 2, p 84 (2018)
The standard of treatment for botulism, equine antitoxin, is a foreign protein with associated safety issues and a short serum half-life which excludes its use as a prophylactic antitoxin and makes it a less-than-optimal therapeutic. Due to these lim
Externí odkaz:
https://doaj.org/article/bda61dc1667e434a82809f2a43e8daa6
Autor:
Yongfeng Fan, Isin N Geren, Jianbo Dong, Jianlong Lou, Weihua Wen, Fraser Conrad, Theresa J Smith, Leonard A Smith, Mengfei Ho, Melissa Pires-Alves, Brenda A Wilson, James D Marks
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135306 (2015)
The paralytic disease botulism is caused by botulinum neurotoxins (BoNT), multi-domain proteins containing a zinc endopeptidase that cleaves the cognate SNARE protein, thereby blocking acetylcholine neurotransmitter release. Antitoxins currently used
Externí odkaz:
https://doaj.org/article/9b7eb01863404d988154a05871b0cbf5
Autor:
Qianyuan Ran, Xiaowei Jiang, Yingya Zhang, Shanyuan Gao, Pengcheng Li, Heng Pan, Lingbo Tang, Liuyihan Song, Jie Zhang, Pan Pan, Fei Feng, Hao Li, Yong Li, Shaochuang Wang, Zhisheng Xia, Guohui Wang, Jianbo Dong, Xin Long, Zheng Cao, Yiqun Guo
Publikováno v:
IEEE Micro. 41:85-92
Distributed systems have been widely adopted for deep neural networks model training. However, the scalability of distributed training systems is largely bounded by the communication cost. We design a highly efficient collective communication library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4430264854db44907dc8de8c8c7009f1
https://doi.org/10.1109/mm.2021.3091475
https://doi.org/10.1109/mm.2021.3091475
Publikováno v:
Antibody Therapeutics
In this review, we have summarized the current landscape of therapeutic antibody optimization for successful development. By engineering antibodies with display technology, computer-aided design and site mutagenesis, various properties of the therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135ade8de561893741643bccc596b597
https://doi.org/10.1093/abt/tbab003
https://doi.org/10.1093/abt/tbab003