Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Jian-young Wu"'
Autor:
Daniel P. Chapman, Jian-Young Wu
Publikováno v:
Frontiers in Medical Technology, Vol 6 (2024)
Neurological disorders are common, yet many neurological diseases don't have efficacious treatments. The protected nature of the brain both anatomically and physiologically through the blood brain barrier (BBB) make it exceptionally hard to access. R
Externí odkaz:
https://doaj.org/article/e9441f9076e64b178e701b002d619cf0
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 9, p e1010697 (2023)
Propagating waves of activity can be evoked and can occur spontaneously in vivo and in vitro in cerebral cortex. These waves are thought to be instrumental in the propagation of information across cortical regions and as a means to modulate the sensi
Externí odkaz:
https://doaj.org/article/379ebbb70f614ba0b3bc97eef26cee26
Autor:
Stephanie S. Sloley, Bevan S. Main, Charisse N. Winston, Alex C. Harvey, Alice Kaganovich, Holly T. Korthas, Adam P. Caccavano, David N. Zapple, Jian-young Wu, John G. Partridge, Mark R. Cookson, Stefano Vicini, Mark P. Burns
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Repeated head impact exposure can cause memory and behavioural impairments but the physiological changes in the brain are not well understood. Here, the authors reveal synaptic adaptations as a potential mechanism for early abnormal behavioural event
Externí odkaz:
https://doaj.org/article/8e3cddd729eb493188315a1ff611d883
Publikováno v:
Bio-Protocol, Vol 10, Iss 19 (2020)
We describe a protocol for preparing acute brain slices which can produce robust hippocampal sharp wave-ripples (SWRs) in vitro. The protocol is optimized for its simplicity and reliability for the preparation of solutions, slicing, and recovery incu
Externí odkaz:
https://doaj.org/article/c258a9baf91344c9ae979339cf400221
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
GCaMP6f is among the most widely used genetically encoded calcium indicators for monitoring neuronal activity. Applications are at both the cellular and population levels. Here, we explore two important and under-explored issues. First, we have teste
Externí odkaz:
https://doaj.org/article/18c1c3987427485386ef8a5c8ffd077e
Autor:
Chapman, Daniel P., Jian-Young Wu
Publikováno v:
Frontiers in Medical Technology; 2024, p1-9, 9p
Propagating waves of activity can be evoked and can occur spontaneouslyin vivoandin vitro. We examine the properties of these waves as inhibition varies in a cortical slice and then develop several computational models. We first show that in the slic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfc0757f4a1b4eddc770b0ef092b4cde
https://doi.org/10.1101/2022.11.02.514832
https://doi.org/10.1101/2022.11.02.514832
Autor:
Gholam K. Motamedi, Peter G. Jeliazkov, Temitayo O. Oyegbile-Chidi, Sunbin S. Song, Varun D. Sharma, Mihriye Mete, Shara Nawar, Peter E. Turkeltaub, Yong Won Cho, Jian-young Wu
Publikováno v:
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.
We investigated the effects of transcranial alternating stimulation (tACS) in patients with insomnia. Nine patients with chronic insomnia underwent two in-laboratory polysomnography, 2 weeks apart, and were randomized to receive tACS either during th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be56f6a5db6e6342886cf5ed5eebf5f
https://pubmed.ncbi.nlm.nih.gov/35321778
https://pubmed.ncbi.nlm.nih.gov/35321778
Autor:
Seham Alaiyed, Grazyna Rajkowska, Gouri Mahajan, Mondona S. McCann, Katherine Conant, Kenneth J. Kellar, Jian-Young Wu, Craig A. Stockmeier
Publikováno v:
J Neurosci
Emerging evidence suggests that there is a reduction in overall cortical excitatory to inhibitory balance in major depressive disorder (MDD), which afflicts ∼14%-20% of individuals. Reduced pyramidal cell arborization occurs with stress and MDD, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cecd3793783c8c7254bf9370e760993
https://doi.org/10.1523/jneurosci.2387-19.2020
https://doi.org/10.1523/jneurosci.2387-19.2020