Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jian-xue Yang"'
Autor:
Xi-Xi Hou, Long-Fei Mao, Yajie Guo, Chaoxuan Lou, Lan Wang, Rui-Fang Li, Huili Wang, San-Qiang Li, Jian-Xue Yang
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Based on the modification of the structure of dolutegravir, we introduced 1,2,3-triazole moieties with different substituted groups and obtained a lot of novel dolutegravir derivatives. The activity of A549 cells treated with the derivatives was exam
Externí odkaz:
https://doaj.org/article/137fb1eea7174cd8a708aedb91010b8b
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Indoleamine 2,3-dioxygenase 1 (IDO1) has attracted much attention in the field of cancer immunotherapy as an immunomodulatory enzyme. To identify potential IDO1 inhibitors, a novel series of compounds with N,N-diphenylurea and triazole structures wer
Externí odkaz:
https://doaj.org/article/a17453182b8b4402974fcb3b9e41ca7c
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Erlotinib is a highly specific and reversible epidermal growth factor receptor tyrosine kinase inhibitor for the targeted therapy of non-small-cell lung cancer (NSCLC) However, the efficacy of erlotinib is limited because the development of drug resi
Externí odkaz:
https://doaj.org/article/303f821c77b2496a80ba8f78f937dab6
Autor:
Gui-Qing Xu, Xiao-Qing Gong, Ying-Ying Zhu, Xiao-Jun Yao, Li-Zeng Peng, Ge Sun, Jian-Xue Yang, Long-Fei Mao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Indoleamine 2,3-dioxygenase 1 (IDO1) plays a predominant role in cancer immunotherapy which catalyzes the initial and rate limiting steps of the kynurenine pathway as a key enzyme. To explore novel IDO1 inhibitors, five derivatives of erlotinib-linke
Externí odkaz:
https://doaj.org/article/a3c1820140b647d7b91984df65109fae
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Nineteen erlotinib derivatives bearing different 1,2,3-triazole moieties were designed, synthesized, and evaluated for their potential against different cancer cell lines. The structures of the synthesized compounds were confirmed via1H NMR, 13C NMR,
Externí odkaz:
https://doaj.org/article/61b2911d170c49a9976383264c7eac6c
Publikováno v:
Future Oncology. 15:3579-3585
Aim: To determine the prevalence of Helicobacter pylori infection and correlation between H. pylori infection and single nucleotide polymorphism (SNPs) identified in gastric cardia adenocarcinoma (GCA) patients. Methods: A case control study was perf
Autor:
Ju Yi, Jian Xue Yang
Publikováno v:
Korean Chinese Relations Review. 4:145-167
Publikováno v:
Chinese Law Review. 29:117-135
Publikováno v:
Chinese Law Review. 29:137-159
Autor:
Jie Chen, Zhiguo Chen, Zhi Chao Hou, Kevin B. Jacobs, Hong Li Lin, Sanford M. Dawsey, Maxwell P. Lee, Ilyar Sheyhidin, Ying Fa Zhou, Zi Ming Dong, Chang Wei Feng, Dong Xie, Ji Lin Li, Jing Jing Han, Fu Bao Chang, Yu Liu, Li Guo, Wei Zheng, Xiu Feng Yang, Lian Qun Zhang, Ai Fang Ji, Xin Song, Xiu-Min Li, Xiao Shan Feng, Hong Lei Li, Qin Xian Zhang, Tian Yun Wang, Zhaoming Wang, Song Liang Qiu, Dongyun Zhang, Li-Dong Wang, Sa Tang, Er Tao Guo, Ling Yuan, Zhi Gang Guo, Feng Li, Wu Wei, Xuejun Zhang, Jiang Man Li, Guang Yan Lei, Qi Zhou, Xia Yang, Guo Lan Xing, Linda M. Liao, Xian Bo Zuo, Zeng Lin Fan, Jia Chang, Min Han, Yan Rui Zhang, William Wheeler, Woon-Puay Koh, Amy Hutchinson, Ze Zhong Tang, Jian-Min Yuan, Jing Liu, Wen Yan Cui, Xi Chen, Xian Zeng Wang, Zhou Wang, Kai Yu, Xue Min Li, Jin Sheng Wang, Hai Liu, Joseph F. Fraumeni, Yin Li, Fu You Zhou, Yue Wu, Li Wang, Wan Li Yin, Chang Dong Lu, Lei Fan, Laurie Burdett, Ya-Li Liu, Bao Ping Chen, Zhong Min Fan, Liang Wang, Wong Ho Chow, Fu Sheng Gao, Yan Li, Long Qi Chen, Ran Wang, Fu Guo Zhu, Chao Yuan, Tai Jing Liu, Min Liu, Xiao-Ou Shu, Margaret A. Tucker, Zhi Qin Bao, Zhi Cai Liu, Li Yan Xu, Ti Ding, Jian Wei Kul, Shu Wei Ren, Xiang Zhuang, Stephen J. Chanock, Xian Chang Li, Zhi Yong Wu, Dan Li, Ji Li Chen, Jin Cheng Dong, Jing-Li Ren, Jian Xue Yang, Ai Li Li, Yi Ming Mao, Sheng Li Zhou, Chaoyu Wang, You-Lin Qiao, Zhi Qing Yuan, Wei Zhang, Xue Ke Zhao, Jeff Yuenger, She Gan Gao, Qing-Peng Kong, Charles C. Chung, Nan Hu, Bin Liu, Peng Zhang, Yong-Bing Xiang, Jin Wang, Wei Peng Wang, Carol Giffen, Hai Lin Liu, Yan Long Hu, Alisa M. Goldstein, Liangdan Sun, Lu Wen Wang, Jian Ting Zhao, Shuqing Chen, Wen Jing Fu, Sin Yong Lian, Wen Jun Yang, Christian C. Abnet, Jing Huang, Ming Guo, Wen Liang Zhu, Xin Ying Jian, Liu Qin Yang, Xue Pin Fan, Wen Bin Yue, Wancai Yang, Jin Yan, Ping Tao, Yuan Yuan, Jia Huang, Jin Chang Wei, En Min Li, Jin-Hu Fan, Neal D. Freedman, Qirenwang Qige, Guo Shun Ma, Yuan Fang Chen, Xiu Qin Peng, Yu Tang Gao, Philip R. Taylor, Meredith Yeager, Gao Fu Zhang, Jian Po Wang, Jian Jun Miao, Ji Li Cui, Jun Yan Hong
Publikováno v:
Human Molecular Genetics. 21:2132-2141
Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously