Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jian-su Shao"'
Autor:
Maria Luisa S. Sequeira-Lopez, Á Baldán, Jian Su Shao, R. A. Barve, Scot J. Matkovich, Robert P. Mecham, Mark S. Sands, Colin G. Nichols, R. A. Gomez, Hao Zhang, Russell H. Knutsen, Bruno A. Benitez, Amy E. Riek, S. M. Bindom, Kendall J. Blumer, Richard D. Head, Jisu Oh, Patrick Osei-Owusu, Carlos Bernal-Mizrachi, Geert Carmeliet
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Myeloid cells are known mediators of hypertension, but their role in initiating renin-induced hypertension has not been studied. Vitamin D deficiency causes pro-inflammatory macrophage infiltration in metabolic tissues and is linked to renin-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1176bdb10f2b0a5f6f3ff9a88a1e2ac1
https://lirias.kuleuven.be/handle/123456789/661748
https://lirias.kuleuven.be/handle/123456789/661748
Autor:
Karen Krchma, Kapil Kapoor, Jian Su Shao, Dwight A. Towler, Bart O. Williams, Abraham Behrmann, Ranjan J. Perera, Carolyn Smith, Attila Kovacs, Su Li Cheng, Megan Mead, Yoanna Bello Arredondo, Bindu Ramachandran, Laurence M. Brill
Publikováno v:
Circulation Research. 117:142-156
Rationale: Wnt signaling regulates key aspects of diabetic vascular disease. Objective: We generated SM22-Cre;LRP6(fl/fl);LDLR −/− mice to determine contributions of Wnt coreceptor low-density lipoprotein receptor–related protein 6 (LRP6) in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9bfc097170c4adbf391d5b39e75c97
https://doi.org/10.1161/circresaha.117.306712
https://doi.org/10.1161/circresaha.117.306712
Autor:
Jisu Oh, Jian Su Shao, Richard E. Ostlund, Kathleen Chin, Geert Carmeliet, Carlos Bernal-Mizrachi, Katsuhiko Funai, Oscar L. Sierra, Isra Darwech, Amy E. Riek
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1872-1886 (2015)
Intense effort has been devoted to understanding predisposition to chronic systemic inflammation because it contributes to cardiometabolic disease. We demonstrate that deletion of the macrophage vitamin D receptor (VDR) in mice (KODMAC) is sufficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38805feb4e6f98f78d03f6e6d5c56a0
http://www.sciencedirect.com/science/article/pii/S2211124715002016
http://www.sciencedirect.com/science/article/pii/S2211124715002016
Autor:
Megan Mead, Bindu Ramachandran, Karen Krchma, Jian Su Shao, Yoanna Bello Arredondo, Robert E. Maxson, Dwight A. Towler, Su Li Cheng, Attila Kovacs, Abraham Behrmann
Publikováno v:
Diabetes. 63:4326-4337
When fed high-fat diets, male LDLR−/− mice develop obesity, hyperlipidemia, hyperglycemia, and arteriosclerotic calcification. An osteogenic Msx-Wnt regulatory program is concomitantly upregulated in the vasculature. To better understand the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2493b9fc6634f587af2496166ec442bf
https://doi.org/10.2337/db14-0326
https://doi.org/10.2337/db14-0326
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33:1679-1689
Objective— Endothelial cells (ECs) can undergo an endothelial–mesenchymal transition with tissue fibrosis. Wnt- and Msx2-regulated signals participate in arteriosclerotic fibrosis and calcification. We studied the impact of Wnt7, Msx2, and Dkk1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9f8e36b6d9e0e4198f368ed52689a6
https://doi.org/10.1161/atvbaha.113.300647
https://doi.org/10.1161/atvbaha.113.300647
Publikováno v:
Endocrinology. 153:3897-3910
In LDLR−/− mice fed high-fat diabetogenic diets, osteogenic gene-regulatory programs are ectopically activated in vascular myofibroblasts and smooth muscle cells that promote arteriosclerotic calcium deposition. Msx2-Wnt signaling pathways previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5603eeb9c3ace03c50de635d18298756
https://doi.org/10.1210/en.2012-1216
https://doi.org/10.1210/en.2012-1216
Autor:
Jian Su Shao, Oscar L. Sierra, Kathryn Distelhorst, Su Li Cheng, Dwight A. Towler, Linda R. Halstead
Publikováno v:
Circulation Research. 107:271-282
Rationale : Vascular fibrosis and calcification contribute to diabetic arteriosclerosis, impairing Windkessel physiology necessary for distal tissue perfusion. Wnt family members, upregulated in arteries by the low-grade inflammation of “diabesity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6b1996e57039632421641fe918ee9d
https://doi.org/10.1161/circresaha.110.219899
https://doi.org/10.1161/circresaha.110.219899
Publikováno v:
Hypertension. 55:579-592
Arterial biomineralization processes have been afflicting humans for ≥5 millennia, as realized in 2003 via the computed tomographic imaging of Otzi, the intriguing “ice mummy” discovered in the Tyrolean Alps.1 Patchy abdominal atherosclerotic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6008a6d1841456f9fde37b0231e9e8
https://doi.org/10.1161/hypertensionaha.109.134205
https://doi.org/10.1161/hypertensionaha.109.134205
Autor:
Jun Cai, Emily Huang, Su Li Cheng, Dwight A. Towler, Chung Fang Lai, Abraham Behrmann, Ziyad Al-Aly, Jian Su Shao
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 27:2589-2596
Objective—Aortic calcification is prevalent in type II diabetes (T2DM), enhancing morbidity and tracking metabolic syndrome parameters.Ldlr−/−mice fed high-fat “Westernized” diets (HFD) accumulate aortic calcium primarily in the tunica medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb8825beda36c09d25115089a7826dd
https://doi.org/10.1161/atvbaha.107.153668
https://doi.org/10.1161/atvbaha.107.153668
Autor:
Abe Behrmann, Jun Cai, Jian Su Shao, Ziyad Al Aly, Chung Fang Lai, Dwight A. Towler, Su Li Cheng, Emily Huang
Publikováno v:
Annals of the New York Academy of Sciences. 1117:40-50
Studies of fracture repair have revealed that paracrine endothelial-mesenchymal interactions direct bone formation that restores osseous integrity. Angiogenic growth factors and specific members of the bone morphogenetic protein (BMP) family mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45225b3065f5321582fa3f14fed3fa50
https://doi.org/10.1196/annals.1402.075
https://doi.org/10.1196/annals.1402.075