Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Jian-Ying Chuang"'
Autor:
Chan-Chuan Liu, Wen-Bin Yang, Chia-Hung Chien, Cheng-Lin Wu, Jian-Ying Chuang, Pin-Yuan Chen, Jui-Mei Chu, Siao Muk Cheng, Li-Ying Qiu, Yung-Chieh Chang, Daw-Yang Hwang, Chih-Yuan Huang, Jung-Shun Lee, Kwang-Yu Chang
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-12 (2024)
Abstract The interaction between glioblastoma cells and glioblastoma-associated macrophages (GAMs) influences the immunosuppressive tumor microenvironment, leading to ineffective immunotherapies. We hypothesized that disrupting the communication betw
Externí odkaz:
https://doaj.org/article/8941b26983c14c8cb27f8a700e1b0555
Autor:
Chia-Hung Chien, Chien-Cheng Lai, Jian-Ying Chuang, Jui-Mei Chu, Chan-Chuan Liu, Kwang-Yu Chang
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Background Glioblastoma (GBM), a malignant brain tumor, has poor survival outcomes due to recurrence or drug resistance. We found that SH3GLB1 is a crucial factor for cells to evade temozolomide (TMZ) cytotoxicity through autophagy-mediated
Externí odkaz:
https://doaj.org/article/28fd7d57eb0d4cf989f662cfd0c58b15
Autor:
Chia-Hung Chien, Wen-Bin Yang, Jian-Ying Chuang, Jung-Shun Lee, Wei-An Liao, Chih-Yuan Huang, Pin-Yuan Chen, An-Chih Wu, Shun-Tai Yang, Chien-Cheng Lai, Pei-I Chi, Jui-Mei Chu, Siao Muk Cheng, Chan-Chuan Liu, Daw-Yang Hwang, Shang-Hung Chen, Kwang-Yu Chang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-14 (2022)
Abstract Background The mechanism by which glioblastoma evades temozolomide (TMZ)-induced cytotoxicity is largely unknown. We hypothesized that mitochondria plays a role in this process. Methods RNA transcriptomes were obtained from tumor samples and
Externí odkaz:
https://doaj.org/article/74d3093ae005449f902018ee36784041
Autor:
Yu-Ting Tsai, Wei-Lun Lo, Pin-Yuan Chen, Chiung-Yuan Ko, Jian-Ying Chuang, Tzu-Jen Kao, Wen-Bing Yang, Kwang-Yu Chang, Chia-Yang Hung, Ushio Kikkawa, Wen-Chang Chang, Tsung-I. Hsu
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-17 (2022)
Abstract Background Sp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement of resistance to temozolomide (TMZ). Particularly, the role of Sp1 in metabolic reprogramming for drug resistance remains unknown. Methods RNA-Seq and
Externí odkaz:
https://doaj.org/article/41e5eb2931d64c3ea1398dfe091319be
Autor:
An-Chih Wu, Wen-Bin Yang, Kwang-Yu Chang, Jung-Shun Lee, Jing-Ping Liou, Ruei-Yuan Su, Siao Muk Cheng, Daw-Yang Hwang, Ushio Kikkawa, Tsung-I Hsu, Chih-Yang Wang, Wen-Chang Chang, Pin-Yuan Chen, Jian-Ying Chuang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Glioblastoma (GBM) is the most aggressive and lethal brain tumor. Although the histone deacetylase (HDAC)/transcription factor axis promotes growth in GBM, whether HDACs including HDAC6 are involved in modulating long non-coding R
Externí odkaz:
https://doaj.org/article/d9672530025d48d3b6d942240400f4bd
Autor:
Wen-Bin Yang, An-Chih Wu, Tsung-I Hsu, Jing-Ping Liou, Wei-Lun Lo, Kwang-Yu Chang, Pin-Yuan Chen, Ushio Kikkawa, Shung-Tai Yang, Tzu-Jen Kao, Ruei-Ming Chen, Wen-Chang Chang, Chiung-Yuan Ko, Jian-Ying Chuang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-13 (2021)
Abstract DNA repair promotes the progression and recurrence of glioblastoma (GBM). However, there remain no effective therapies for targeting the DNA damage response and repair (DDR) pathway in the clinical setting. Thus, we aimed to conduct a compre
Externí odkaz:
https://doaj.org/article/0550dd11627c4cb1b510f29cabb3b452
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-10 (2021)
Abstract Glioblastoma is the most common primary malignant brain tumor that is usually considered fatal even with treatment. This is often a result for tumor to develop resistance. Regarding the standard chemotherapy, the alkylating agent temozolomid
Externí odkaz:
https://doaj.org/article/e173d53f3d9b4a06a9bc97046848c866
Autor:
Pin-Tse Lee, Jean-Charles Liévens, Shao-Ming Wang, Jian-Ying Chuang, Bilal Khalil, Hsiang-en Wu, Wen-Chang Chang, Tangui Maurice, Tsung-Ping Su
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The (G4C2)-RNA hexanucleotide repeat expansion upstream of the start codon of the C9orf72 gene plays a critical role in familial ALS. The authors show that Sig1R, a ligand-regulated molecular chaperone, counteracts the aberrant nucleocytoplasmic dist
Externí odkaz:
https://doaj.org/article/3e69e0a8edd7453b8b1babe7a2048d98
Autor:
Chia-Hung Chien, Jian-Ying Chuang, Shun-Tai Yang, Wen-Bin Yang, Pin-Yuan Chen, Tsung-I Hsu, Chih-Yuan Huang, Wei-Lun Lo, Ka-Yen Yang, Ming-Sheng Liu, Jui-Mei Chu, Pei-Hsuan Chung, Jr-Jiun Liu, Shao-Wen Chou, Shang-Hung Chen, Kwang-Yu Chang
Publikováno v:
Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-16 (2019)
Abstract Background Intratumor subsets with tumor-initiating features in glioblastoma are likely to survive treatment. Our goal is to identify the key factor in the process by which cells develop temozolomide (TMZ) resistance. Methods Resistant cell
Externí odkaz:
https://doaj.org/article/a4d420e0b4e94a6d81430e61fa42269e
Autor:
Chie-Hong Wang, Hsuan-Cheng Wu, Chen-Wei Hsu, Yun-Wei Chang, Chiung-Yuan Ko, Tsung-I Hsu, Jian-Ying Chuang, Tsui-Hwa Tseng, Shao-Ming Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14727 (2022)
Myeloid zinc finger 1 (MZF1), also known as zinc finger protein 42, is a zinc finger transcription factor, belonging to the Krüppel-like family that has been implicated in several types of malignancies, including glioblastoma multiforme (GBM). MZF1
Externí odkaz:
https://doaj.org/article/994897ef970a4b32af532cf84701327b