Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Jian-Xin Lin"'
Autor:
Jian-Xin Lin, Meili Ge, Cheng-yu Liu, Ronald Holewinski, Thorkell Andresson, Zu-Xi Yu, Tesfay Gebregiorgis, Rosanne Spolski, Peng Li, Warren J. Leonard
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Cytokine-mediated STAT5 protein activation is vital for lymphocyte development and function. In vitro tyrosine phosphorylation of a C-terminal tyrosine is critical for activation of STAT5A and STAT5B; however, the importance of STAT5 tyrosin
Externí odkaz:
https://doaj.org/article/5ba4ab354a1b44359620c2fe7b2cfec5
Autor:
Roland C. Schelker, Jessica Fioravanti, Fabio Mastrogiovanni, Jeremy G. Baldwin, Nisha Rana, Peng Li, Ping Chen, Timea Vadász, Rosanne Spolski, Christoph Heuser-Loy, Dragana Slavkovic-Lukic, Pedro Noronha, Giuseppe Damiano, Laura Raccosta, Daniela Maggioni, Sree Pullugula, Jian-Xin Lin, Jangsuk Oh, Patrick Grandinetti, Mario Lecce, Leo Hesse, Emilia Kocks, Azucena Martín-Santos, Claudia Gebhard, William G. Telford, Yun Ji, Nicholas P. Restifo, Vincenzo Russo, Michael Rehli, Wolfgang Herr, Warren J. Leonard, Luca Gattinoni
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract High frequencies of stem-like memory T cells in infusion products correlate with superior patient outcomes across multiple T cell therapy trials. Herein, we analyzed a published CRISPR activation screening to identify transcriptional regulat
Externí odkaz:
https://doaj.org/article/feb411feca9c417783b76fb6c8d7a885
Autor:
Kelly L. Monaghan, Wen Zheng, Halima Akhter, Lei Wang, Amanda G. Ammer, Peng Li, Jian-Xin Lin, Gangqing Hu, Warren J. Leonard, Edwin C. K. Wan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In response to external stimuli during immune responses, monocytes can have multifaceted roles such as pathogen clearance and tissue repair. However, aberrant control of monocyte activation can result in chronic inflammation and subsequent tissue dam
Externí odkaz:
https://doaj.org/article/12045bbafd524595805dc67907514100
Autor:
Robert Sertori, Jian-Xin Lin, Esteban Martinez, Sadhna Rana, Andrew Sharo, Majid Kazemian, Uma Sunderam, Mark Andrake, Susan Shinton, Billy Truong, Roland M. Dunbrack, Chengyu Liu, Rajgopol Srinivasan, Steven E. Brenner, Christine M. Seroogy, Jennifer M. Puck, Warren J. Leonard, David L. Wiest
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Newborn screening for severe combined immunodeficiency (SCID) has not only accelerated diagnosis and improved treatment for affected infants, but also led to identification of novel genes required for human T cell development. A male proband had SCID
Externí odkaz:
https://doaj.org/article/c3ee77ae0a46475588d40b1044048c27
Autor:
Jian-Xin Lin, Ning Du, Peng Li, Majid Kazemian, Tesfay Gebregiorgis, Rosanne Spolski, Warren J. Leonard
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for N
Externí odkaz:
https://doaj.org/article/b737b1cb8b61414c848b3ccab3e8881b
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160339 (2016)
STAT proteins bind DNA as dimers and tetramers to control cellular development, differentiation, survival, and expansion. The tetramer binding sites are comprised of two dimer-binding sites repeated in tandem. The genome-wide distribution of the spac
Externí odkaz:
https://doaj.org/article/9d27a6851e2b4d02829b13c847f8dda3
Autor:
Jian-Xin Lin, 林建欣
97
The present work investigated the effect of electromigration on the tensile properties of the Sn-8.5Zn-0.5Ag-0.01Al-0.1Ga alloy. The current density and the testing temperature were kept at ~2.5 x 103A/cm2 and 70°C, respectively. Besides, in
The present work investigated the effect of electromigration on the tensile properties of the Sn-8.5Zn-0.5Ag-0.01Al-0.1Ga alloy. The current density and the testing temperature were kept at ~2.5 x 103A/cm2 and 70°C, respectively. Besides, in
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/90034869760396751184
Autor:
Masao Hashimoto, Koichi Araki, Maria A. Cardenas, Peng Li, Rohit R. Jadhav, Haydn T. Kissick, William H. Hudson, Donald J. McGuire, Rebecca C. Obeng, Andreas Wieland, Judong Lee, Daniel T. McManus, James L. Ross, Se Jin Im, Junghwa Lee, Jian-Xin Lin, Bin Hu, Erin E. West, Christopher D. Scharer, Gordon J. Freeman, Arlene H. Sharpe, Suresh S. Ramalingam, Alex Pellerin, Volker Teichgräber, William J. Greenleaf, Christian Klein, Jorg J. Goronzy, Pablo Umaña, Warren J. Leonard, Kendall A. Smith, Rafi Ahmed
Publikováno v:
Nature. 610:173-181
Autor:
Elissa K. Leonard, Jakub Tomala, Joseph R. Gould, Michael I. Leff, Jian-Xin Lin, Peng Li, Mitchell J. Porter, Eric R. Johansen, Ladaisha Thompson, Shanelle D. Cao, Tereza Henclova, Maros Huliciak, Ondřej Vaněk, Marek Kovar, Warren J. Leonard, Jamie B. Spangler
Publikováno v:
bioRxiv
Progress in cytokine engineering is driving therapeutic translation by overcoming the inherent limitations of these proteins as drugs. The interleukin-2 (IL-2) cytokine harbors great promise as an immune stimulant for cancer treatment. However, the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54754f6a0554337f424d63dc906193b
https://europepmc.org/articles/PMC10187205/
https://europepmc.org/articles/PMC10187205/
Autor:
Xin-Qiang Lin, Yu-Ren Chen, Xiao Chen, Yu-Ping Cai, Jian-Xin Lin, De-Ming Xu, Xiao-Chun Zheng
Publikováno v:
World Journal of Clinical Cases. 10:6082-6090