Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jian-Xin Duan"'
Autor:
Charles P. Hart, Mark D. Matteucci, Peter M. Glazer, Gregory C. Stachelek, Adam V. Patterson, Robert F. Anderson, Andrej Maroz, Christopher P. Guise, Alexandra M. Mowday, Xiaohong Cai, Jian-Xin Duan, Gustavo Lorente, Leslie Lan, Monica Banica, Deepthi Bhupathi, James W. Evans, Fanying Meng
TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard currently undergoing clinical evaluation. Here, we describe broad-spectrum activity, hypoxia-selective activation, and mechanism of action of TH-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1647daf3bd322e5dd347e898918fddfd
https://doi.org/10.1158/1535-7163.c.6535963
https://doi.org/10.1158/1535-7163.c.6535963
Autor:
Charles P. Hart, Mark D. Matteucci, John G. Curd, W. Steve Ammons, Jian-Xin Duan, Yan Wang, Damien Ferraro, Dharmendra Ahluwalia, Jingli Wang, Qian Liu, Jessica D. Sun
PDF file - 2.7MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fcaedba61d40db0e601de0a736eb65
https://doi.org/10.1158/1078-0432.22443263
https://doi.org/10.1158/1078-0432.22443263
Abstract 1220: Selective and broad anti-tumor activity of AKR1C3-activated prodrug AST-3424/OBI-3424
Autor:
Tianyang Qi, Donald Jung, Yin-Cheng Hsieh, Ren-Yu Hsu, Jian-Xin Duan, Wan-Fen Li, Chun-Chung Wang, Fanying Meng, Chi-Sheng Shia
Publikováno v:
Cancer Research. 81:1220-1220
AKR1C3 is overexpressed at both levels of protein and RNA in many types of cancer, particularly in liver, gastric, renal, CRPC and non-small cell lung cancer. High AKR1C3 expression is directly related to treatment resistance and poor prognosis. AST-
Autor:
Narimanne El-Zein, Fanying Meng, Komal S. Rathi, Stephen W. Erickson, Chelsea Mayoh, Yuelong Guo, Kathryn Evans, Connor D. Jones, Cara E. Toscan, Tillman Pearce, Charles G. Mullighan, Richard B. Lock, Jian-Xin Duan, Donald Jung, Kathryn G. Roberts, Zhaohui Gu, Malcolm A. Smith, Lisa McDermott, Chi-Sheng Shia, Beverly A. Teicher, Tara Pritchard
Publikováno v:
Clin Cancer Res
Purpose: OBI-3424 is a highly selective prodrug that is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent. OBI-3424 has entered clinical testing for hepatocellular carcinoma and castrate-resistant prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12232e5a1100ba377a116eb067dda2f7
https://europepmc.org/articles/PMC6635081/
https://europepmc.org/articles/PMC6635081/
Publikováno v:
Journal of Shanghai Jiaotong University (Science). 18:289-292
According to the water balance principle, the expression of the phreatic table is established by considering evaporation and considering evaporation & drainage respectively. The law of phreatic table variation under the combined effects of considerin
Autor:
Yan Wang, Damien Ferraro, Dharmendra Ahluwalia, W. Steve Ammons, Mark D. Matteucci, Lee D. Cranmer, Jian Xin Duan, Jessica D Sun, John G. Curd, Charles P. Hart, Qian Liu, Amanda F. Baker, Jingli Wang
Publikováno v:
Cancer Chemotherapy and Pharmacology. 69:1487-1498
Subregional hypoxia is a common feature of tumors and is recognized as a limiting factor for the success of radiotherapy and chemotherapy. TH-302, a hypoxia-activated prodrug selectively targeting hypoxic regions of solid tumors, delivers a cytotoxic
Autor:
W. Steve Ammons, Damien Ferraro, Jingli Wang, Qian Liu, Yan Wang, Charles P. Hart, Dharmendra Ahluwalia, Jian-Xin Duan, John G. Curd, Mark D. Matteucci, Jessica D Sun
Publikováno v:
Clinical Cancer Research. 18:758-770
Purpose: Tumor hypoxia underlies treatment failure and yields a more aggressive, invasive, and metastatic cancer phenotype. TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM). The
Publikováno v:
Cancer Chemotherapy and Pharmacology. 69:643-654
To characterize the pharmacokinetics of the prodrug, TH-302, and its active metabolite, bromo-IPM (Br-IPM), in nonclinical species.TH-302 was administered in single oral, intraperitoneal and intravenous bolus doses to mice, rats, dogs and monkeys as
Autor:
Yuelong Guo, Richard B. Lock, Kathryn Evans, Raymond Yung, Tara Pritchard, Beverly A. Teicher, Malcolm A. Smith, Jian-Xin Duan, Stephen W. Erickson
Publikováno v:
Molecular Cancer Therapeutics. 17:LB-B16
Introduction: Aldo-keto reductase family 1 member C3 (AKR1C3) belongs to a superfamily of oxidoreductases that are broadly expressed in human tissues. AKR1C3 catalyzes the reduction of a diverse group of substrates, and is expressed at high levels in
Autor:
Yian Zhai, Ion Ghiviriga, Katsu Ogawa, Merle A. Battiste, Jian-Xin Duan, Wei Xu, William R. Dolbier
Publikováno v:
Collection of Czechoslovak Chemical Communications. 73:1764-1776
Octafluoro[2.2]paracyclophane (AF4) has been oxidized by treatment with HIO3 in CF3CO2H to form the corresponding p-quinone along with a unique triketone. This quinone undergoes reduction to the respective hydroquinone as well as a Diels-Alder reacti