Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jian-Sung Wu"'
Autor:
Chun Hei Antonio Cheung, Su-Ying Wu, Tian-Ren Lee, Chi-Yen Chang, Jian-Sung Wu, Hsing-Pang Hsieh, Jang-Yang Chang
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12564 (2010)
BACKGROUND: Anti-mitotic compounds (microtubule de-stabilizers) such as vincristine and vinblastine have been shown clinically successful in treating various cancers. However, development of drug-resistance cells limits their efficacies in clinical s
Externí odkaz:
https://doaj.org/article/7cb7d81d9d094bce88afcb97162b9c74
Autor:
John T.A. Hsu, Jian-Sung Wu, Shiu Hwa Yeh, Shu Yu Lin, Wen-Chi Hsiao, Andrew Yueh, Jen-Shin Song, Chia-Ling Hsieh, Yi-Hui Peng, Ming-Shiu Hung, Lung-Chun Lee, Chia-Yeh Liu, Shau-Hua Ueng, Su-Ying Wu, Mine-Hsine Wu, Chuan Shih, Shu-Yi Lin, Teng-Kuang Yeh, Fang-Yu Liao, Chun-Hwa Chen
Publikováno v:
Journal of Medicinal Chemistry. 58:7807-7819
A structure-based virtual screening strategy, comprising homology modeling, ligand-support binding site optimization, virtual screening, and structure clustering analysis, was developed and used to identify novel tryptophan 2,3-dioxygenase (TDO) inhi
Autor:
Su Ying Wu, Ming Han Tsai, Jia Ni Tian, Ren Huang Wu, Kuen Nan Tsai, Chun-Hong Chen, Jyh-Haur Chern, Andrew Yueh, Jian Sung Wu
Publikováno v:
Journal of Virology. 91
The NS2A protein of dengue virus (DENV) has eight predicted transmembrane segments (pTMS1 to -8) and participates in RNA replication, virion assembly, and host antiviral response. However, the roles of specific amino acid residues within the pTMS reg
Autor:
Mine-Hsine Wu, Ming-Shiu Hung, Chuan Shih, Shu Yu Lin, Fang-Yu Liao, Jian-Sung Wu, Shau-Hua Ueng, Su-Ying Wu, Chia-Ling Hsieh, Yu-Sheng Chao, Ming-Fu Cheng, Wen-Chi Hsiao, Jen-Shin Song
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3403-3406
A novel class of phenyl benzenesulfonylhydrazides has been identified as potent inhibitors of indoleamine 2,3-dioxygenase (IDO), and their structure–activity relationship was explored. Coupling reactions between various benzenesulfonyl chlorides an
Autor:
Jing Ping Liou, Min Chieh Su, Su Ying Wu, Samir Mehndiratta, Chih Ying Nien, Hsueh Yun Lee, Ching Chuan Kuo, Shiow Lin Pan, Mei Jung Lai, Chi Yen Chang, Jian Sung Wu, Jang Yang Chang, Yi Min Liu, Yi Ting Chang
Publikováno v:
Journal of Medicinal Chemistry. 56:8008-8018
Preliminary biological data on 7-anilino-6-azaindoles (8-11) suggested that hydrophobic substituents at C7 contribute to enhancement of antiproliferative activity. A novel series of 7-aryl-6-azaindole-1-benzenesulfonamides (12-22) were developed and
Autor:
Weir-Torn Jiaang, Ping-Chiang Lyu, Wen-Hsing Lin, Chuan Shih, Su-Ying Wu, Jian-Sung Wu, Chih-Hsiang Tu, Chun-Yu Chang, Cheng-Tai Lu, Yi-Hui Peng, Tsu Hsu
Publikováno v:
Journal of medicinal chemistry. 59(8)
Most anaplastic lymphoma kinase (ALK) inhibitors adopt a type I binding mode, but only limited type II ALK structural studies are available. Herein, we present the structure of ALK in complex with N1-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)
Autor:
Fang Yu Liao, Yi Hui Peng, Chia-Ling Hsieh, Han Li Huang, Wen-Chi Hsiao, Shau-Hua Ueng, Shu Yu Lin, Ming Fu Cheng, Chun Yu Yang, Jian Sung Wu, Ming Shiu Hung, Manwu Sun, Su Ying Wu, Chuan Shih, Jen Shin Song, Shiow Lin Pan, Teng Kuang Yeh, Li Mei Lin, Ching Chuan Kuo, Min Wu Chao, Mine Hsine Wu, Yi Lin Chen, Yu-Sheng Chao
Publikováno v:
Journal of medicinal chemistry. 59(1)
Tryptophan metabolism has been recognized as an important mechanism in immune tolerance. Indoleamine 2,3-dioxygenase plays a key role in local tryptophan metabolism via the kynurenine pathway and has emerged as a therapeutic target for cancer immunot
Autor:
Mine-Hsine Wu, Chuan Shih, Chih-Hsiang Tu, Ming-Shiu Hung, Shau-Hua Ueng, Chen-Tso Tseng, Wen-Chi Hsiao, Lung-Chun Lee, Kak-Shan Shia, Yu-Shiou Fan, Jen-Shin Song, Jian-Sung Wu, Ming-Fu Cheng, Shu Yu Lin, Yi-Hui Peng, Fang-Yu Liao, Ching-Cheng Hsueh, Chia-Yi Cheng, Su-Ying Wu
Publikováno v:
Journal of medicinal chemistry. 59(1)
Indoleamine 2,3-dioxygenase 1 (IDO1), promoting immune escape of tumors, is a therapeutic target for the cancer immunotherapy. A number of IDO1 inhibitors have been identified, but only limited structural biology studies of IDO1 inhibitors are availa
Autor:
Mei Hsiang Lin, Jing Ping Liou, Hsing Pang Hsieh, Ching-Chuan Kuo, Hsueh Yun Lee, Kuang-Shing Shey, Mei-Jung Lai, Jian-Sung Wu, Su-Ying Wu, Jang Yang Chang, Chi-Yen Chang
Publikováno v:
European Journal of Medicinal Chemistry. 46:3623-3629
A novel series of the biheterocycles-based compounds with core structure distinguished from combretastatin A-4 (1) and colchicine (5) have been synthesized and evaluated as potent anti-mitotic agents. Compound 1-(4'-Indolyl and 6'-quinolinyl)-4,5,6-t
Autor:
Teng Kuang Yeh, Jang Yang Chang, Chin Yu Lin, Chi Yen Chang, Su Ying Wu, Hsing Pang Hsieh, Paritosh Shukla, Jing Ping Liou, Ching Chuan Kuo, Chun Wei Chang, Hui Yi Shiao, Yen Shih Tung, Chun-Chen Liao, Yu-Shan Wu, Mohane Selvaraj Coumar, Jian Sung Wu
Publikováno v:
Journal of Medicinal Chemistry. 54:3076-3080
Utilizing scaffold-hopping drug-design strategy, we sought to identify a backup drug candidate for BPR0L075 (1), an indole-based anticancer agent. For this purpose, 5,6-fused bicyclic heteroaromatic scaffolds were designed and synthesized through shu