Zobrazeno 1 - 10
of 959
pro vyhledávání: '"Jian-Ping ZHANG"'
Autor:
Zhi-Xue Yang, Dong-Hao Deng, Zhu-Ying Gao, Zhi-Kang Zhang, Ya-Wen Fu, Wei Wen, Feng Zhang, Xiang Li, Hua-Yu Li, Jian-Ping Zhang, Xiao-Bing Zhang
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The potential for off-target mutations is a critical concern for the therapeutic application of CRISPR-Cas9 gene editing. Current detection methodologies, such as GUIDE-seq, exhibit limitations in oligonucleotide integration efficiency and s
Externí odkaz:
https://doaj.org/article/ca2357b3dbc94140bda92191948be5cd
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundThe microbial-gut-brain axis has received much attention in recent years, and regulating intestinal flora can effectively improve sleep disorders, which hints the potential effects of probiotics on sleep disorders, but lack of research evid
Externí odkaz:
https://doaj.org/article/d2bf5b6f6c0947c88fc9ae10de35b5a1
Autor:
Man-man Zhang, Ming-jun Liang, Dong-mei Zhang, Jun-nan Cai, Quan-jun Yang, Yun-Zhao, Jian-ping Zhang, Yang-ling Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117237- (2024)
The Lysosomal Protein Transmembrane 5 (LAPTM5) is a lysosomal transmembrane protein preferentially expressed in hematopoietic cells. The human LAPTM5 gene is located at position 1p34 and extends approximately 25 kb. Its protein includes five transmem
Externí odkaz:
https://doaj.org/article/40f0b1c2a5b142718a453a952fcf2474
Autor:
Juan-Juan Zhao, Xin-Yu Sun, Sai-Ning Tian, Zong-Ze Zhao, Meng-Di Yin, Mei Zhao, Feng Zhang, Si-Ang Li, Zhi-Xue Yang, Wei Wen, Tao Cheng, An Gong, Jian-Ping Zhang, Xiao-Bing Zhang
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background CRISPR-Cas9 technology has advanced in vivo gene therapy for disorders like hemophilia A, notably through the successful targeted incorporation of the F8 gene into the Alb locus in hepatocytes, effectively curing this disorder in
Externí odkaz:
https://doaj.org/article/6b00ee3c16a94b60a7273e094f61df57
Autor:
Zhi-Xue Yang, Ya-Wen Fu, Juan-Juan Zhao, Feng Zhang, Si-Ang Li, Mei Zhao, Wei Wen, Lei Zhang, Tao Cheng, Jian-Ping Zhang, Xiao-Bing Zhang
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 6, Pp 1206-1220 (2023)
A series of clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 (Cas9) systems have been engineered for genome editing. The most widely used Cas9 is SpCas9 from Streptococcus pyogenes and SaCas9 from Staphyl
Externí odkaz:
https://doaj.org/article/dd9a845d89064b8db6bec0665d9eb342
Autor:
Zheng-Li Xu, Lan-Ping Xu, Yi-Cheng Zhang, Yu-Hong Zhou, Er-Lie Jiang, Jian-Ping Zhang, Bin Fu, Gui-Fang Ouyang, Xian-Min Song, Xue-Jun Zhang, Yu-Jun Dong, Nai-Nong Li, Ling Wang, Xi Zhang, Peng-Cheng He, Fan-Sheng Kong, Hui-Xia Liu, Li Liu, Lin Liu, Tai-Wu Xiao, Wen-Wei Xu, Xiao-Jun Xu, Guo-Lin Yuan, Hai Yi, Dan Yu, Li Yu, Xiao-Jun Huang
Publikováno v:
Haematologica, Vol 109, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/6df7ea5a8d1642998e2e25a6869da3f2
Autor:
Hua Fang, Hua-Feng Li, Miao Yang, Ru-Rong Wang, Quan-Yun Wang, Peng-Cheng Zheng, Fang-Xiang Zhang, Jian-Ping Zhang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 114874- (2023)
Externí odkaz:
https://doaj.org/article/17bf36c425a34ca58de1c2d9104b6437
Autor:
Ying Zhang, Hui-Hui Hu, Shi-Hong Zhou, Wu-Yan Xia, Yan Zhang, Jian-Ping Zhang, Xiao-Long Fu, Wen Yu
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-10 (2023)
Abstract Background Cumulative preclinical and clinical evidences showed radiotherapy might augment systemic antitumoral responses to immunotherapy for metastatic non-small cell lung cancer, but the optimal timing of combination is still unclear. The
Externí odkaz:
https://doaj.org/article/93196e365a0345f68fb7eb24e5fad17f
Autor:
Jin-Ze Li, Bao-You Fan, Tao Sun, Xiao-Xiong Wang, Jun-Jin Li, Jian-Ping Zhang, Guang-Jin Gu, Wen-Yuan Shen, De-Rong Liu, Zhi-Jian Wei, Shi-Qing Feng
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 3, Pp 626-633 (2023)
Ferroptosis plays a key role in aggravating the progression of spinal cord injury (SCI), but the specific mechanism remains unknown. In this study, we constructed a rat model of T10 SCI using a modified Allen method. We identified 48, 44, and 27 ferr
Externí odkaz:
https://doaj.org/article/b13aad43703a4694acb7d5d9f06229ee
Publikováno v:
HemaSphere, Vol 7, p e670715b (2023)
Externí odkaz:
https://doaj.org/article/398b215be1c944a384c243aa3f183e34