Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jian-Nong Ma"'
Autor:
David, Malin, Mallori, Henceroth, Gadam Srinivas, Rao, Joseph, Campbell, Jian-Nong, Ma, Ping-Hsun, Tsai, Jordan C, Kishbaugh, Ethan S, Burstein
Publikováno v:
Neuroscience letters. 713
Previous work has shown that chronic nicotine administration causes adaptive changes in 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b36772416a8d62656ed779ef1f9e6cab
https://pubmed.ncbi.nlm.nih.gov/31585211
https://pubmed.ncbi.nlm.nih.gov/31585211
Autor:
Christian Ottmann, Anja Schäfer, Ethan S. Burstein, Marcus Malo, Luc Brunsveld, Henrik Sundén, Jian-Nong Ma, Seppe Leysen, Roger Olsson, Marcel Scheepstra
Publikováno v:
Journal of Medicinal Chemistry, 59(3), 1232-1238. American Chemical Society
The nuclear receptor Nurr1 can be activated by RXR via heterodimerization (RXR-Nurr1) and is a promising target for treating neurodegenerative diseases. We herein report the enantioselective synthesis and SAR of sterically constricted benzofurans at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0138ca0805ae22bbf0bf30d8e7b046ff
https://doi.org/10.1021/acs.jmedchem.5b01702
https://doi.org/10.1021/acs.jmedchem.5b01702
Autor:
Marcel Scheepstra, Christian Ottmann, Jian-Nong Ma, Femke A. Meijer, Roger Olsson, Ethan S. Burstein, Rens M J M de Vries, Luc Brunsveld, Sebastian A. Andrei, Lech-Gustav Milroy
Publikováno v:
ACS Chemical Neuroscience
ACS Chemical Neuroscience, 8(9), 2065-2077. American Chemical Society
ACS chemical neuroscience 8(9), 2065-2077 (2017). doi:10.1021/acschemneuro.7b00216
ACS Chemical Neuroscience, 8(9), 2065-2077. American Chemical Society
ACS chemical neuroscience 8(9), 2065-2077 (2017). doi:10.1021/acschemneuro.7b00216
Retinoid X receptors (RXRs) play key roles in many physiological processes in both the periphery and central nervous system. In addition, RXRs form heterodimers with other nuclear receptors to exert their physiological effects. The nuclear receptor r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b3fbe2538f4b6de28283ad946d8051
https://pubmed.ncbi.nlm.nih.gov/28691794
https://pubmed.ncbi.nlm.nih.gov/28691794
Autor:
Joseph R. Campbell, Ethan S. Burstein, Jian-Nong Ma, Mallori M. Henceroth, David H. Malin, Gadam Srinivas Rao, Ping-Hsun Tsai, Jordan C. Kishbaugh
Publikováno v:
Neuroscience Letters. 713:134524
Previous work has shown that chronic nicotine administration causes adaptive changes in 5-HT2A receptor expression. Based on this relationship, it was hypothesized that inactivating 5-HT2A receptors with the inverse agonists pimavanserin and volinans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86bed88d8e64e15fae0d5e419346ea6e
https://doi.org/10.1016/j.neulet.2019.134524
https://doi.org/10.1016/j.neulet.2019.134524
Autor:
Weissman, Jacques T.1, Jian-Nong Ma, Jacques T.1, Essex, Anthony1, Yan Gao1, Burstein, Ethan S.1 eburstein@acadia-pharm.com
Publikováno v:
Oncogene. 1/8/2004, Vol. 23 Issue 1, p241-249. 9p. 2 Diagrams, 2 Charts, 8 Graphs.
Autor:
Tracy A. Spalding, Roger Olsson, David Hubbard, Jian-Nong Ma, Ethan S. Burstein, Krista McFarland
Publikováno v:
ACS Chemical Neuroscience. 4:1430-1438
Nurr1 is a nuclear hormone receptor (NucHR) strongly implicated in the growth, maintenance, and survival of dopaminergic neurons. Nurr1 may be unable to bind ligands directly, but it forms heterodimers with other NucHRs that do. Using bioluminescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3003582dfc9e19c1df7c5a597a9c4fd
https://doi.org/10.1021/cn400100f
https://doi.org/10.1021/cn400100f
Autor:
Lars Kr. Hansen, Anna-Lena Gustavsson, Henrik Sundén, Roger Olsson, Jian-Nong Ma, Ethan S. Burstein
Publikováno v:
ChemMedChem. 8:1283-1294
Selective activation of the estrogen receptor β (ERβ) could be a safe approach to hormone replacement therapy for both women and men, in contrast to the estrogens currently used for women which activate both ERβ and ERα, occasionally causing seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cefe693924181a558f7dee01505b30d
https://doi.org/10.1002/cmdc.201300175
https://doi.org/10.1002/cmdc.201300175
Publikováno v:
ACS chemical neuroscience. 7(9)
Chemotherapy-induced neuropathic pain (CINP) remains a major unmet medical need. Estrogen receptor beta (ERβ)-selective agonists represent a novel strategy for treating CINP because they are neuroprotective and may also have anticancer activity. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7525b7eb291220ba82581d88bc5aac83
https://pubmed.ncbi.nlm.nih.gov/27456785
https://pubmed.ncbi.nlm.nih.gov/27456785
Autor:
Ethan S. Burstein, Roger Olsson, Erika A. Currier, Sine Mandrup Bertozzi, Jacob Jensen, Jian Nong Ma, Magnus Gustafsson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5918-5921
1-(Benzothiazol-2-yl)-1-(4-chlorophenyl)ethanol (1) was identified as a positive allosteric modulator (PAM) of the CaSR in a functional cell-based assay. This compound belongs to a class of compounds that is structurally distinct from other known pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9df1ef25c95cb9e2c6edebe6bf9fa8
https://doi.org/10.1016/j.bmcl.2010.07.077
https://doi.org/10.1016/j.bmcl.2010.07.077
Autor:
Roger Olsson, Erika A. Currier, Jian Nong Ma, Fredrik Lehmann, Ethan S. Burstein, Kristina Luthman, Uli Hacksell
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:4844-4854
A series of novel isochromanone based urotensin II receptor agonists have been synthesized and evaluated for their activity using a functional cell based assay (R-SAT). Several potent and efficacious derivatives were identified with 3-(3,4-dichloroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9270d95d9ec241b2965f0b87881f0160
https://doi.org/10.1016/j.bmc.2010.04.041
https://doi.org/10.1016/j.bmc.2010.04.041