Zobrazeno 1 - 10 of 57 pro vyhledávání: '"Jian-Mei Gao"'
1
Akademický článek
Trilobatin, a Natural Food Additive, Exerts Anti-Type 2 Diabetes Effect Mediated by Nrf2/ARE and IRS-1/GLUT2 Signaling Pathways
Autor: Yan-Ling Shi, Yue-Ping Zhang, Huan Luo, Fan Xu, Jian-Mei Gao, Jing-Shan Shi, Qi-Hai Gong
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Oxidative stress and aberrant insulin signaling transduction play vital roles in type 2 diabetes mellitus (T2DM). Our previous research has demonstrated that trilobatin (TLB), derived from the leaves of Lithocarpus Polystachyus (Wall.), exhibits a po
Externí odkaz: https://doaj.org/article/5f83f567d89f415fa00feb73c94039d6
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2
Akademický článek
Trilobatin, a Component from Lithocarpus polystachyrus Rehd., Increases Longevity in C. elegans Through Activating SKN1/SIRT3/DAF16 Signaling Pathway
Autor: Na Li, Xi Li, Yan-Ling Shi, Jian-Mei Gao, Yu-Qi He, Fei Li, Jing-Shan Shi, Qi-Hai Gong
Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Trilobatin (TLB) is an effective component from Lithocarpus polystachyrus Rehd. Our previous study revealed that TLB protected against oxidative injury in neuronal cells by AMPK/Nrf2/SIRT3 signaling pathway. However, whether TLB can delay aging remai
Externí odkaz: https://doaj.org/article/f6038d95b94b44b4b032cab88d80ea04
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3
Akademický článek
Synthesis of a New Phenyl Chlormethine-Quinazoline Derivative, a Potential Anti-Cancer Agent, Induced Apoptosis in Hepatocellular Carcinoma Through Mediating Sirt1/Caspase 3 Signaling Pathway
Autor: Jia-jia Lv, Wen-ting Song, Xin-min Li, Jian-mei Gao, Ze-li Yuan
Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)
Quinazoline derivatives display multiple pharmacological activities and target various biological receptors. Based on the skeleton of quinazoline core, we designed and synthesized three new quinazoline-phenyl chlormethine conjugates (I–III) bearing
Externí odkaz: https://doaj.org/article/304558230be94d5a8917fc9f217cf8bb
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4
Akademický článek
Gastrodin Attenuates Bilateral Common Carotid Artery Occlusion-Induced Cognitive Deficits via Regulating Aβ-Related Proteins and Reducing Autophagy and Apoptosis in Rats
Autor: Bo Liu, Jian-Mei Gao, Fei Li, Qi-Hai Gong, Jing-Shan Shi
Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)
Gastrodin (GAS), an active constituent extracted from Gastrodia elata Blume, is used to treat ischemic stroke, epilepsy, dizziness, and dementia for centuries in China. This study examined its effects on vascular dementia (VD) and the underlying mole
Externí odkaz: https://doaj.org/article/4e0ebcdb982c42688d2af36f0e9cd2b7
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6
Trilobatin, a Natural Food Additive, Exerts Anti-Type 2 Diabetes Effect Mediated by Nrf2/ARE and IRS-1/GLUT2 Signaling Pathways
Autor: Yan-Ling Shi, Yue-Ping Zhang, Huan Luo, Fan Xu, Jian-Mei Gao, Jing-Shan Shi, Qi-Hai Gong
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Oxidative stress and aberrant insulin signaling transduction play vital roles in type 2 diabetes mellitus (T2DM). Our previous research has demonstrated that trilobatin (TLB), derived from the leaves of Lithocarpus Polystachyus (Wall.), exhibits a po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f967c1ffd355ede68e71b37912ce896
https://pubmed.ncbi.nlm.nih.gov/35153796
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7
Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway
Autor: Jian-mei Gao, Xun Zhang, Guo-tao Shu, Na-na Chen, Jian-yong Zhang, Fan Xu, Fei Li, Yuan-gui Liu, Yu Wei, Yu-qi He, Jing-shan Shi, Qi-hai Gong
Publikováno v: Acta pharmacologica Sinica. 43(10)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive impairment that currently is uncurable. Previous study shows that trilobatin (TLB), a naturally occurring food additive, exerts neuroprotective effect in experimental
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf0bb0595affdc2695a395230df46ee
https://pubmed.ncbi.nlm.nih.gov/35292770
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8
Identification of a homozygous BBS7 frameshift mutation in two (related) Chinese Miao families with Bardet-Biedl Syndrome
Autor: Qian Zhao, Xin-Min Yan, Jin-ping Zhang, Li Li, Tao Shou, Tao Shen, Jian-Mei Gao
Publikováno v: Journal of the Chinese Medical Association. 82:110-114
Background Bardet-Biedl Syndrome (BBS) is a genetically heterogeneous autosomal recessive disorder with a wide spectrum of clinical features. To date, mutations in 21 different genes (BBS1-21) have been identified as causing isolated or complex BBS p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aaf2f28880ad30dc6073f31efdd6d8a
https://doi.org/10.1097/jcma.0000000000000011
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