Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Jian-Hua Ran"'
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Akademický článek
Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines
Autor: Tao Zhang, Ling Hu, Jia-Feng Tang, Hang Xu, Kuan Tian, Meng-Na Wu, Shi-Ying Huang, Yu-Mei Du, Peng Zhou, Rui-Jin Lu, Shuang He, Jia-Mei Xu, Jian-Jun Si, Jing Li, Di-Long Chen, Jian-Hua Ran
Publikováno v: Molecules, Vol 26, Iss 7, p 1990 (2021)
The urea cycle (UC) removes the excess nitrogen and ammonia generated by nitrogen-containing compound composites or protein breakdown in the human body. Research has shown that changes in UC enzymes are not only related to tumorigenesis and tumor dev
Externí odkaz: https://doaj.org/article/f00a08e3e70b4074a73be5d074dcee4c
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2
Akademický článek
Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1
Autor: Ling Hu, Kuan Tian, Tao Zhang, Chun-Hua Fan, Peng Zhou, Di Zeng, Shuang Zhao, Li-Sha Li, Hendrea Shaniqua Smith, Jing Li, Jian-Hua Ran
Publikováno v: Molecules, Vol 24, Iss 18, p 3231 (2019)
Chronic kidney disease (CKD) is problem that has become one of the major issues affecting public health. Extensive clinical data suggests that the prevalence of hyperlipidemia in CKD patients is significantly higher than in the general population. Li
Externí odkaz: https://doaj.org/article/7018acb9e91c48d58068422786342d17
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4
The anti-hepatocellular carcinoma effects of polysaccharides from Ganoderma lucidum by regulating macrophage polarization via the MAPK/NF-κB signaling pathway
Autor: Guo-li Li, Jia-feng Tang, Wen-li Tan, Tao Zhang, Di Zeng, Shuang Zhao, Jian-hua Ran, Jing Li, Ya-ping Wang, Di-long Chen
Publikováno v: Food & Function. 14:3155-3168
Ganoderma lucidum polysaccharide (GLPS) can inhibit hepatocellular carcinoma (HCC). But the mechanism of GLPS's effect is little known. This data showed that GLPS can regulate MAPK/NF-κB signaling responsible for M1 polarization in anti-HCC.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2048a0a1b997989ee1f8268e20d52cb3
https://doi.org/10.1039/d2fo02191a
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5
1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia
Autor: Xiao-Wei, Li, Jian-Hua, Ran, Hong, Zhou, Jin-Zhao, He, Zhi-Wei, Qiu, Shu-Yuan, Wang, Meng-Na, Wu, Shuai, Zhu, Yong-Pan, An, Ang, Ma, Min, Li, Ya-Zhu, Quan, Nan-Nan, Li, Chao-Qun, Ren, Bao-Xue, Yang
Publikováno v: Acta Pharmacologica Sinica. 44:406-420
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. Cyst development in ADPKD involves abnormal epithelial cell proliferation, which is affected by the primary cilia-mediated signal transduction in the ep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cb361a1367cbb410f90f86f55a4367
https://doi.org/10.1038/s41401-022-00937-z
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6
Neuroglobin expression and function in the temporal cortex of bilirubin encephalopathy rats
Autor: Chun-Yan Chen, Ping Fan, Jian-hua Ran, Li-Rong Zhang, Jia-Heng Hu, Wei-Tian Lu, Guo-Ping Qiu, Juan Huang, Shengwei Gan, Shiye Xu, Shujuan Zhu, Jin Xu
Publikováno v: The Anatomical Record. 305:254-264
Bilirubin encephalopathy (BE) is a neurological syndrome in newborns, mainly caused by neuronal injury due to excessive oxidative stress produced by unconjugated bilirubin (UCB). Neuroglobin (NGB) can protect the brain by removing oxidative stress sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9950a9d4c9007fbd218e5ed35d303185
https://doi.org/10.1002/ar.24734
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7
The anatomic study and surgical technique for lumbar spinal canal decompression with 'pedicle-plasty' strategy
Autor: Zuo-Zhong Liu, Lei Shi, Zheng-Jian Yan, Jian-Hua Ran, Xi-yan Xu, Zhong-Liang Deng
Background Disc and facet joint are essential for motion between vertebrae.In the treatment of lumbar burst fractures,intervertebral fusion or posterolateral fusion is often required after spinal decompression to rebuild spinal stability, but it may
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ba246d902207dde38984cae241a96c4
https://doi.org/10.21203/rs.3.rs-1401821/v1
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8
Brusatol Inhibits Proliferation and Metastasis of Colorectal Cancer by Targeting and Reversing the RhoA/ROCK1 Pathway
Autor: Rui-jin Lu, Guo-zhi Zhao, Rong Jiang, Shuang He, Hang Xu, Jia-ming He, Yue Sun, Meng-na Wu, Jian-hua Ran, Di-long Chen, Jing Li
Publikováno v: BioMed Research International.
Brusatol (BRU) is an important compound extracted from Brucea javanica oil, whose pharmacological effects are able to induce a series of biological effects, including inhibition of tumor cell growth, anti-inflammatory, antiviral, and antitumor. Curre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ed7421150340a1f659ab838ad87efa
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10
Phenylphthalazines as small-molecule inhibitors of urea transporter UT-B and their binding model
Autor: Jian-hua Ran, Weng-Ieong Tou, Tianluo Lei, Hong Zhou, Calvin Yu-Chian Chen, Min Li, Baoxue Yang
Publikováno v: Acta Pharmacologica Sinica. 37:973-983
Urea transporters (UT) are a family of transmembrane proteins that specifically transport urea. UT inhibitors exert diuretic activity without affecting electrolyte balance. The purpose of this study was to discover novel UT inhibitors and determine t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7881ff6ed5a69fe0d6fc041762c7ae00
https://doi.org/10.1038/aps.2016.4
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