Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jian-Bin Qiao"'
Autor:
Qian-Qian Fan, Cheng-Lu Zhang, Junho Byun, Hu-Lin Jiang, Jian-Bin Qiao, Xiang-Dong Gao, Jaiwoo Lee, Lei Xing, Yu-Kyoung Oh
Publikováno v:
Journal of Controlled Release. 321:629-640
Liver fibrosis leads to over one million deaths annually worldwide. Hepatic stellate cells (HSCs) have been identified as the main executors of liver fibrosis. Unfortunately, no drug has yet been approved for clinical use against liver fibrosis, larg
Autor:
Qian-Qian Fan, Chaofeng Zhang, Tao Pang, Jing-Cheng Zhu, Peng-Fei Cui, Hu-Lin Jiang, Yu-Kyoung Oh, Yu-Jing He, Lei Xing, Jian-Bin Qiao, Lirui Wang
Publikováno v:
Journal of Controlled Release. 283:113-125
Liver fibrosis refers to excessive accumulation of hepatic collagen, which is primarily produced by activated hepatic stellate cells (HSCs). No effective drugs are clinically available to treat this condition, reflecting the fact that antifibrotic dr
Autor:
Tian-Jiao Zhou, Qing-Ri Jin, Xin Chang, Jian-Bin Qiao, Ru-Yi Yu, Yu-Jing He, Hu-Lin Jiang, Lei Xing, Peng-Fei Cui, Yanyu Xiao
Publikováno v:
Biomaterials Science. 6:2144-2155
Finding a cure for breast cancer currently remains a medical challenge in due to the failure of common treatment methods to inhibit invasion and metastasis of cancer cells, which eventually leads to recurrence of breast cancer. Many secreted proteins
Autor:
Peng-Fei Cui, Jiang Hulin, Huabing Chen, Yong Zhu, Yu-Jing He, Jian-Bin Qiao, Mei Zhang, Ge Jiang, Xing Lei, Na Lu, Hengte Ke
Publikováno v:
ACS Applied Materials & Interfaces. 9:11337-11344
Multidrug resistance (MDR) greatly impedes the therapeutic efficacy of chemotherapeutic agents. Overexpression of ATP-binding cassette (ABC) transporters, such as P-gp, on the surface of tumor cells is a major mechanism in MDR. In this study, we fabr
Autor:
Jian-Bin Qiao, Yu-Jing He, Myung-Haing Cho, Soo Min Lee, Lei Xing, Hu-Lin Jiang, Sung-Hyun Hwang, Yoonjeong Jang, Peng-Fei Cui, Qian-Qian Fan, Seung-Hee Chang
Publikováno v:
Polymer Chemistry. 8:1540-1554
Safe and efficient drug delivery systems have received great attention for cancer therapy due to their enhanced cancer-targeting efficiency and reduced undesirable side effects. Administration, safety, and effectiveness are the main issues for clinic
Autor:
Liang Jin, Peng-Fei Cui, Jian-Bin Qiao, Hu-Lin Jiang, Baoan Chen, Lei Xing, Cheng-Qiong Luo, Yu-Jing He
Publikováno v:
International Journal of Nanomedicine
Cheng-Qiong Luo,1–3,* Lei Xing,1–3,* Peng-Fei Cui,1 Jian-Bin Qiao,1 Yu-Jing He,1 Bao-An Chen,4 Liang Jin,1,2,5 Hu-Lin Jiang1–3 1State Key Laboratory of Natural Medicines, Department of Pharmaceutics, 2Jiangsu Key Laboratory of Drug Screening, 3
Autor:
Lei Xing, Yu-Kyoung Oh, Jian-Bin Qiao, Qian-Qian Fan, Cheng-Lu Zhang, Peng-Fei Cui, Hu-Lin Jiang
Publikováno v:
Biomaterials. 230
As hepatic stellate cells (HSCs) are essential for hepatic fibrogenesis, HSCs targeted nano-drug delivery system is a research hotspot in liver fibrosis therapy. However, the excessive deposition of fibrosis collagen (mainly collagen I) in the space
Autor:
Jia-Liang Zhang, Peng-Fei Cui, Bing-Feng Zhang, Feng-Zhen Wang, Hu-Lin Jiang, Jian-Bin Qiao, Lei Xing, Cheng-Xiong Xu
Publikováno v:
International Journal of Pharmaceutics. 506:207-213
Based on development of nano-delivery system, co-delivery of chemotherapeutic drug and small interfering RNA (siRNA) has exerted a promising advantage in cancer therapy. In this work, the superiority of synergistic therapy and safety of the hierarchi
Autor:
Yu-Jing He, Peng-Fei Cui, Jian-Bin Qiao, Jia-Liang Zhang, Lei Xing, Qing-Ri Jin, Cheng-Qiong Luo, Wan-Ru Zhuang, Hu-Lin Jiang
Publikováno v:
Polymer Chemistry. 7:7416-7426
Limited delivery options have hindered the development of nucleic acid drugs in clinical practice. Inspired by the natural DNA compressing ability of histones, herein we have synthesized novel polymeric carriers called PCAmHn designed to mimic the hi
Autor:
Hu-Lin Jiang, Jian-Bin Qiao, Peng-Fei Cui, Shunai Che, Jia-Liang Zhang, Lei Xing, Tuo jin, Jia-Hui Gong, Jin-Yuan Lyu, Yu-Jing He
Publikováno v:
RSC Advances. 6:65854-65865
The co-delivery of platinum(IV) prodrugs and nucleic acids has emerged as a new modality for cancer therapy. However, as a result of the different molecular properties of nucleic acids and platinum(IV) prodrugs, the co-delivery of platinum(IV) prodru