Zobrazeno 1 - 10
of 1 987
pro vyhledávání: '"Jian You"'
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-43 (2024)
Abstract In the last decade, messenger ribonucleic acid (mRNA)-based drugs have gained great interest in both immunotherapy and non-immunogenic applications. This surge in interest can be largely attributed to the demonstration of distinct advantages
Externí odkaz:
https://doaj.org/article/73322e6a71614745b7043c2fca4097e4
Autor:
Hendrik N. J. Kuijer, Jian You Wang, Salim Bougouffa, Michael Abrouk, Muhammad Jamil, Roberto Incitti, Intikhab Alam, Aparna Balakrishna, Derry Alvarez, Cristina Votta, Guan-Ting Erica Chen, Claudio Martínez, Andrea Zuccolo, Lamis Berqdar, Salim Sioud, Valentina Fiorilli, Angel R. de Lera, Luisa Lanfranco, Takashi Gojobori, Rod A. Wing, Simon G. Krattinger, Xin Gao, Salim Al-Babili
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The yield of pearl millet, a resilient cereal crop crucial for African food security, is severely impacted by the root parasitic weed Striga hermonthica, which requires host-released hormones, called strigolactones (SLs), for seed germinatio
Externí odkaz:
https://doaj.org/article/112bab48414a49b8a3ae35f737b8a5ed
Autor:
Ji Wang, Shiquan Shen, Jian You, Zhaotao Wang, Yan Li, Yanming Chen, Yonghua Tuo, Danmin Chen, Haoming Yu, Jingbo Zhang, Fangran Wang, Xiao Pang, Zongyu Xiao, Qing Lan, Yezhong Wang
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-13 (2024)
Abstract Invasion and migration are the key hallmarks of cancer, and aggressive growth is a major factor contributing to treatment failure and poor prognosis in glioblastoma. Protein arginine methyltransferase 6 (PRMT6), as an epigenetic regulator, h
Externí odkaz:
https://doaj.org/article/94d993e7d01f479fb3405fccedb7cb20
Autor:
Xianglong Li, Kaiguo Xia, Chuanhong Zhong, Xiangzhou Chen, Fubing Yang, Ligang Chen, Jian You
Publikováno v:
Brain Research Bulletin, Vol 216, Iss , Pp 111050- (2024)
Background: G protein-coupled receptor 68 (GPR68), an orphan receptor, has emerged as a promising therapeutic target for mitigating neuronal inflammation and oxidative damage. This study explores the protective mechanisms of GPR68 in cerebral ischemi
Externí odkaz:
https://doaj.org/article/ebb7b104ff1f4ac79bed4c11b9ca70c4
Publikováno v:
Cancer Biology & Medicine, Vol 21, Iss 4, Pp 274-311 (2024)
Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient’s own immune system and eliminate cancer cells. One of the most exciting advances within this field is the targeting of n
Externí odkaz:
https://doaj.org/article/69c77fca518842848a2e37416ef925c3
Autor:
Yunxiao He, Yujiao Zhang, Jiangnan Li, Zhiyi Ren, Wenjing Zhang, Xianghua Zuo, Wei Zhao, Ming Xing, Jian You, Xia Chen
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Plants adapt to cold stress through a tightly regulated process involving metabolic reprogramming and tissue remodeling to enhance tolerance within a short timeframe. However, the precise differences and interconnections among various organs during c
Externí odkaz:
https://doaj.org/article/5a0d72c4ac694c458f8bfc1295b41b5a
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundDespite significant benefits from targeted therapy in patients with driver mutations, inevitable drug resistance usually occurred in non-small cell lung cancer, highlighting the necessity for sequential treatments to prolong overall surviva
Externí odkaz:
https://doaj.org/article/2dbe0b3373594e9ea3db3f9d330d609e
Autor:
Yichao Lu, Zhenyu Luo, Huanli Zhou, Yingying Shi, Ying Zhu, Xuemeng Guo, Jiaxin Huang, Junlei Zhang, Xu Liu, Sijie Wang, Xinyu Shan, Hang Yin, Yongzhong Du, Qingpo Li, Jian You, Lihua Luo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Obesity often leads to severe medical complications. However, existing FDA-approved medications to combat obesity have limited effectiveness in reducing adiposity and often cause side effects. These medications primarily act on the central n
Externí odkaz:
https://doaj.org/article/138fbac84ea047248f3c37f7dc94de99
Autor:
Jian You Wang, Muhammad Jamil, Turki S. AlOtaibi, Mohamed E. Abdelaziz, Tsuyoshi Ota, Omer H. Ibrahim, Lamis Berqdar, Tadao Asami, Magdi Ali Ahmed Mousa, Salim Al-Babili
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Climate changes and the rapid expanding human population have become critical concerns for global food security. One of the promising solutions is the employment of plant growth regulators (PGRs) for increasing crop yield and overcoming adve
Externí odkaz:
https://doaj.org/article/fa9ed6781504477e9c1ccc794241b9ef
Autor:
Pengpeng Yue, Xiaoyan Lv, Jian You, Yongkang Zou, Jun luo, Zhongshan Lu, Hankun Cao, Zhongzhong Liu, Xiaoli Fan, Qifa Ye
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-21 (2023)
Abstract Background Hepatic ischemia–reperfusion injury (IRI) in donation after cardiac death (DCD) donors is a major determinant of transplantation success. Endoplasmic reticulum (ER) stress plays a key role in hepatic IRI, with potential involvem
Externí odkaz:
https://doaj.org/article/676692f362484202aeebeacbca2a6857