Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Jian V. Zhang"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Centromere pairing is crucial for synapsis in meiosis. This study delves into the Skp1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complex, specifically focusing on F-box protein 47 (FBXO47), in mouse meiosis. Here, we revealed that FBXO
Externí odkaz:
https://doaj.org/article/05a4b34e7b6e474bacc178380da3e36f
Autor:
Di Gao, Chao Li, Shao-Yuan Liu, Teng-Teng Xu, Xiao-Ting Lin, Yong-Peng Tan, Fu-Min Gao, Li-Tao Yi, Jian V. Zhang, Jun-Yu Ma, Tie-Gang Meng, William S. B. Yeung, Kui Liu, Xiang-Hong Ou, Rui-Bao Su, Qing-Yuan Sun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Histone lysine crotonylation, an evolutionarily conserved modification differing from acetylation, exerts pivotal control over diverse biological processes. Among these are gene transcriptional regulation, spermatogenesis, and cell cycle pro
Externí odkaz:
https://doaj.org/article/4969af9773a140c1aab6f028ea2c3592
Autor:
Chiyuan Ma, Qin Li, Yuxin Yang, Lei Ge, Jiaxuan Cai, Juan Wang, Maoxian Zhu, Yue Xiong, Wenya Zhang, Jingtong Xie, Yujing Cao, Huashan Zhao, Qing Wei, Chen Huang, Junchao Shi, Jian V. Zhang, Enkui Duan, Xiaohua Lei
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Background Metabolic homeostasis is closely related to early impairment of cell fate determination and embryo development. The protein kinase mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism in the body. Inhib
Externí odkaz:
https://doaj.org/article/dab35b1e993e4b47a963665eb8d4c2eb
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9945 (2024)
Endochondral ossification is the process by which cartilage is mineralized into bone, and is essential for the development of long bones. Osteocalcin (OCN), a protein abundant in bone matrix, also exhibits high expression in chondrocytes, especially
Externí odkaz:
https://doaj.org/article/2a079da42bd64454aa9fc4217742fc3a
Autor:
Chenxi Guo, Yuan Xiao, Jingkai Gu, Peikun Zhao, Zhe Hu, Jiahuan Zheng, Renwu Hua, Zhuo Hai, Jiaping Su, Jian V. Zhang, William S. B. Yeung, Tianren Wang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial unfolded protein response to maintain protein homeostasis in the mitochondria. However, the r
Externí odkaz:
https://doaj.org/article/7eec63554d104627a26887fc7c255ae6
Autor:
Jiajian Wang, Caihong Liu, Litao Yang, Huixiong Chen, Mingqi Zheng, Yanbin Wan, Xiongxin Hong, Sidi Li, Jing Han, Ruibin Luo, Xing Wan, Jian V. Zhang, Ruihuan Xu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The patterns of communication among different chondrocyte subtypes in human cartilage degeneration and regeneration help us understand the microenvironment of osteoarthritis and optimize cell-targeted therapies. Here, a single-cell transcrip
Externí odkaz:
https://doaj.org/article/6ee8ae16919d4506a5581a9e351ca55c
Autor:
Goher Kerem, Xiangfang Yu, Aynur Ismayi, Bin Teng, Anjaneyulu Udduttula, Chang Liu, Zhongjia Yu, Dilbar Tohty, Jian V. Zhang, Pei-Gen Ren
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Obesity has become a global concern because of increasing the risk of many diseases. Alterations in human gut microbiota have been proven to be associated with obesity, yet the mechanism of how the microbiota are altered by high salt diet (H
Externí odkaz:
https://doaj.org/article/5a5e41ffdcdd463097682c51cc5ea31b
Autor:
Lunbo Tan, Zijun Ouyang, Zhilong Chen, Fen Sun, Haichun Guo, Feng Wang, Monique Mulder, Yuan Sun, Xifeng Lu, Jian V. Zhang, A. H. Jan Danser, Koen Verdonk, Xiujun Fan, Qing Yang
Publikováno v:
Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background The adipokine chemerin regulates adipogenesis and the metabolic function of both adipocytes and liver. Chemerin is elevated in preeclamptic women, and overexpression of chemerin in placental trophoblasts induces preeclampsia-like
Externí odkaz:
https://doaj.org/article/beef8a9d4bf445a09c81bcfb09bc48d8
Autor:
Zhenyu Yao, Jun Meng, Jing Long, Long Li, Weicong Qiu, Cairong Li, Jian V. Zhang, Pei‐Gen Ren
Publikováno v:
FEBS Open Bio, Vol 13, Iss 1, Pp 89-101 (2023)
Type 2 diabetes (T2DM) is characterized by insulin secretion deficiencies and systemic insulin resistance (IR) in adipose tissue, skeletal muscle, and the liver. Although the mechanism of T2DM is not yet fully known, inflammation and insulin resistan
Externí odkaz:
https://doaj.org/article/0e4745df9a4e4a478564d1cffe25ff4c
Publikováno v:
BMC Pregnancy and Childbirth, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Maternal gestational diabetes mellitus (GDM) had long-term influences on the health of their children. However, the influences of GDM on the oral microbiota, which was closely related to oral and systemic health in offspring, were
Externí odkaz:
https://doaj.org/article/9171bfd244d34af29fe0a903d6839258