Výsledky vyhledávání - "Jian Sung Wu"

Akademický článek

Cancer cells acquire mitotic drug resistance properties through beta I-tubulin mutations and alterations in the expression of beta-tubulin isotypes.

Autor: Chun Hei Antonio Cheung, Su-Ying Wu, Tian-Ren Lee, Chi-Yen Chang, Jian-Sung Wu, Hsing-Pang Hsieh, Jang-Yang Chang

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12564 (2010)

BACKGROUND: Anti-mitotic compounds (microtubule de-stabilizers) such as vincristine and vinblastine have been shown clinically successful in treating various cancers. However, development of drug-resistance cells limits their efficacies in clinical s

Externí odkaz: https://doaj.org/article/7cb7d81d9d094bce88afcb97162b9c74

Zobrazit plný text záznamu

Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening

Publikováno v: Journal of Medicinal Chemistry. 58:7807-7819

A structure-based virtual screening strategy, comprising homology modeling, ligand-support binding site optimization, virtual screening, and structure clustering analysis, was developed and used to identify novel tryptophan 2,3-dioxygenase (TDO) inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f6d48ff04d4c03236ee06acbd01311
https://doi.org/10.1021/acs.jmedchem.5b00921

Zobrazit plný text záznamu

Mutagenesis of Dengue Virus Protein NS2A Revealed a Novel Domain Responsible for Virus-Induced Cytopathic Effect and Interactions between NS2A and NS2B Transmembrane Segments

Autor: Su Ying Wu, Ming Han Tsai, Jia Ni Tian, Ren Huang Wu, Kuen Nan Tsai, Chun-Hong Chen, Jyh-Haur Chern, Andrew Yueh, Jian Sung Wu

Publikováno v: Journal of Virology. 91

The NS2A protein of dengue virus (DENV) has eight predicted transmembrane segments (pTMS1 to -8) and participates in RNA replication, virion assembly, and host antiviral response. However, the roles of specific amino acid residues within the pTMS reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769a741ddc73c9ef191fcdbef63a2fb4
https://doi.org/10.1128/jvi.01836-16

Zobrazit plný text záznamu

Furanylazaindoles: Potent Anticancer Agents in Vitro and in Vivo

Autor: Jing Ping Liou, Min Chieh Su, Su Ying Wu, Samir Mehndiratta, Chih Ying Nien, Hsueh Yun Lee, Ching Chuan Kuo, Shiow Lin Pan, Mei Jung Lai, Chi Yen Chang, Jian Sung Wu, Jang Yang Chang, Yi Min Liu, Yi Ting Chang

Publikováno v: Journal of Medicinal Chemistry. 56:8008-8018

Preliminary biological data on 7-anilino-6-azaindoles (8-11) suggested that hydrophobic substituents at C7 contribute to enhancement of antiproliferative activity. A novel series of 7-aryl-6-azaindole-1-benzenesulfonamides (12-22) were developed and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9bd86678e44a0d4b22f2632a6a1a2a9
https://doi.org/10.1021/jm4011115

Zobrazit plný text záznamu

Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK)

Autor: Weir-Torn Jiaang, Ping-Chiang Lyu, Wen-Hsing Lin, Chuan Shih, Su-Ying Wu, Jian-Sung Wu, Chih-Hsiang Tu, Chun-Yu Chang, Cheng-Tai Lu, Yi-Hui Peng, Tsu Hsu

Publikováno v: Journal of medicinal chemistry. 59(8)

Most anaplastic lymphoma kinase (ALK) inhibitors adopt a type I binding mode, but only limited type II ALK structural studies are available. Herein, we present the structure of ALK in complex with N1-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dbb1d6b01301cb128a028280c6e5ca
https://pubmed.ncbi.nlm.nih.gov/27031565

Zobrazit plný text záznamu

Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents

Autor: Mei Hsiang Lin, Jing Ping Liou, Hsing Pang Hsieh, Ching-Chuan Kuo, Hsueh Yun Lee, Kuang-Shing Shey, Mei-Jung Lai, Jian-Sung Wu, Su-Ying Wu, Jang Yang Chang, Chi-Yen Chang

Publikováno v: European Journal of Medicinal Chemistry. 46:3623-3629

A novel series of the biheterocycles-based compounds with core structure distinguished from combretastatin A-4 (1) and colchicine (5) have been synthesized and evaluated as potent anti-mitotic agents. Compound 1-(4'-Indolyl and 6'-quinolinyl)-4,5,6-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29d3c55471ee39525b96820d204c57e
https://doi.org/10.1016/j.ejmech.2011.04.065

Zobrazit plný text záznamu

Scaffold-Hopping Strategy: Synthesis and Biological Evaluation of 5,6-Fused Bicyclic Heteroaromatics To Identify Orally Bioavailable Anticancer Agents

Autor: Teng Kuang Yeh, Jang Yang Chang, Chin Yu Lin, Chi Yen Chang, Su Ying Wu, Hsing Pang Hsieh, Paritosh Shukla, Jing Ping Liou, Ching Chuan Kuo, Chun Wei Chang, Hui Yi Shiao, Yen Shih Tung, Chun-Chen Liao, Yu-Shan Wu, Mohane Selvaraj Coumar, Jian Sung Wu

Publikováno v: Journal of Medicinal Chemistry. 54:3076-3080

Utilizing scaffold-hopping drug-design strategy, we sought to identify a backup drug candidate for BPR0L075 (1), an indole-based anticancer agent. For this purpose, 5,6-fused bicyclic heteroaromatic scaffolds were designed and synthesized through shu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3eefd1e0f719d648b04b95b716d0ff
https://doi.org/10.1021/jm101027s

Zobrazit plný text záznamu

Structural Basis for the Improved Potency of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists

Autor: John T.A. Hsu, Tzu Wen Lien, Xin Chen, Jiun Shyang Leou, Chia Hui Lin, Yi Hui Peng, Wen-Hsing Lin, Jian Sung Wu, Chien Fu Huang, Yu-Sheng Chao, Hsing Pang Hsieh, Su Ying Wu, Hui Yi Shiao, Mohane Selvaraj Coumar, Ping-Chiang Lyu

Publikováno v: ChemMedChem. 5:1707-1716

The need to develop safer and more effective antidiabetic drugs is essential owing to the growth worldwide of the diabetic population. Targeting the PPAR receptor is one strategy for the treatment of diabetes; the PPAR agonists rosiglitazone and piog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0fdd812416a9c74611f97bb7b7b244
https://doi.org/10.1002/cmdc.201000194

Zobrazit plný text záznamu

5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors

Autor: Jian Sung Wu, Jing Ping Liou, Su Ying Wu, Chih Ying Nien, Jang Yang Chang, Yun Ching Chen, Chi Yen Chang, Ching Chuan Kuo, Hsing Pang Hsieh

Publikováno v: Journal of Medicinal Chemistry. 53:2309-2313

A series of aroylquinoline derivatives were synthesized and evaluated for anticancer activity. 5-Amino-6-methoxy-2-aroylquinoline 15 showed more potent antiproliferative activity (IC(50) values ranging from 0.2 to 0.4 nM) as compared to 1a (combretas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fe4101e7599a42c9d366f20e26c431
https://doi.org/10.1021/jm900685y

Zobrazit plný text záznamu

Generation of Ligand-Based Pharmacophore Model and Virtual Screening for Identification of Novel Tubulin Inhibitors with Potent Anticancer Activity

Autor: Ping-Chiang Lyu, Ching-Chuan Kuo, Ming-Hsine Wu, Yu-Shan Wu, Jen-Shin Song, Jiun-Shyang Leou, Huan-Yi Jseng, Su-Ying Wu, Hsing Pang Hsieh, Chi-Yen Chang, Yu-Sheng Chao, Chung-Tong Chen, Jang Yang Chang, Yi-Kun Chiang, Jian-Sung Wu, Mohane Selvaraj Coumar

Publikováno v: Journal of Medicinal Chemistry. 52:4221-4233

A pharmacophore model, Hypo1, was built on the basis of 21 training-set indole compounds with varying levels of antiproliferative activity. Hypo1 possessed important chemical features required for the inhibitors and demonstrated good predictive abili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd366b3cf3e69c02a6140e6ca22457b
https://doi.org/10.1021/jm801649y

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání