Výsledky vyhledávání - "Jian Shu Lou"

Akademický článek

Berberine Improves Inflammatory Responses of Diabetes Mellitus in Zucker Diabetic Fatty Rats and Insulin-Resistant HepG2 Cells through the PPM1B Pathway

Autor: Yang Sheng Wu, Zhe Ming Li, Yi Tao Chen, Shi Jie Dai, Xiao Jie Zhou, Yuan Xiao Yang, Jian Shu Lou, Li Ting Ji, Yu Ting Bao, Ling Xuan, Lu Ning Lin, Chang Yu Li

Publikováno v: Journal of Immunology Research, Vol 2020 (2020)

Berberine (BBR), a natural compound extracted from a Chinese herb, has been shown to effectively attenuate insulin resistance (IR) and inflammation in the clinic. However, its ameliorative mechanism against IR is not well defined. This study is aimed

Externí odkaz: https://doaj.org/article/c75ab5616bef453eb38980fbbab6da5b

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Akademický článek

Distinct binding conformations of epinephrine with α- and β-adrenergic receptors

Autor: Jian-Shu Lou, Minfei Su, Jinan Wang, Hung Nguyen Do, Yinglong Miao, Xin-Yun Huang

Publikováno v: Experimental and Molecular Medicine, Vol 56, Iss 9, Pp 1952-1966 (2024)

Abstract Agonists targeting α2-adrenergic receptors (ARs) are used to treat diverse conditions, including hypertension, attention-deficit/hyperactivity disorder, pain, panic disorders, opioid and alcohol withdrawal symptoms, and cigarette cravings.

Externí odkaz: https://doaj.org/article/39057a4010c94a3f87205a27fe7825f5

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Akademický článek

β-Elemene induced ferroptosis via TFEB-mediated GPX4 degradation in EGFR wide-type non-small cell lung cancer

Autor: Li-Ping Zhao, Hao-Jie Wang, Die Hu, Jun-Hu Hu, Zheng-Rong Guan, Li-Hua Yu, Ya-Ping Jiang, Xiao-Qi Tang, Zhao-Huang Zhou, Tian Xie, Jian-Shu Lou

Publikováno v: Journal of Advanced Research, Vol 62, Iss , Pp 257-272 (2024)

Introduction: β-Elemene (β-ELE), derived from Curcuma wenyujin, has anticancer effect on non-small cell lung cancer (NSCLC). However, the potential target and detail mechanism were still not clear. TFEB is the master regulator of lysosome biogenesi

Externí odkaz: https://doaj.org/article/6f41ae41c6de4938ab8e6923be52beb5

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Akademický článek

Therapeutic effect of Sheng Mai San, a traditional Chinese medicine formula, on inflammatory bowel disease via inhibition of NF-κB and NLRP3 inflammasome signaling

Autor: Magnolia Muk-Lan Lee, Brandon Dow Chan, Yuen-Wa Ng, Tsz-Wing Leung, Tan-Yu Shum, Jian-Shu Lou, Wing-Yan Wong, William Chi-Shing Tai

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

IntroductionInflammatory bowel disease (IBD) is a globally emergent chronic inflammatory disease which commonly requires lifelong care. To date, there remains a pressing need for the discovery of novel anti-inflammatory therapeutic agents against thi

Externí odkaz: https://doaj.org/article/9386fa8292604dd59fef4fd706752e53

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Akademický článek

Corrigendum to 'Hyperprogression, a challenge of PD-1/PD-L1 inhibitors treatments: potential mechanisms and coping strategies' [Biomed. Pharmacother. 150 (2022) 112949]

Autor: Li-ping Zhao, Jun-hu Hu, Die Hu, Hao-jie Wang, Chang-gang Huang, Ru-hua Luo, Zhao-huang Zhou, Xin-yun Huang, Tian Xie, Jian-shu Lou

Publikováno v: Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114944- (2023)

Externí odkaz: https://doaj.org/article/e3c69ad6c7ea4d628407ab9ac521ca6f

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Akademický článek

Hyperprogression, a challenge of PD-1/PD-L1 inhibitors treatments: potential mechanisms and coping strategies

Autor: Li-ping Zhao, Jun-hu Hu, Die Hu, Hao-jie Wang, Chang-gang Huang, Ru-hua Luo, Zhao-huang Zhou, Xin-yun Huang, Tian Xie, Jian-shu Lou

Publikováno v: Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 112949- (2022)

Immunotherapy is now a mainstay in cancer treatments. Programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) immune checkpoint inhibitor (ICI) therapies have opened up a new venue of advanced cancer immunotherapy. However, hyperprogres

Externí odkaz: https://doaj.org/article/a073f1e42a5e4d81bffd712dc3e3abb1

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