Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jian Sheng Lu"'
Autor:
Gulisaina Qiaerxie, Yujia Jiang, Gege Li, Zhixin Yang, Feng Long, Yunzhou Yu, Jian Sheng Lu, Peng Du, Yong Cui
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Among all natural and synthetic toxins, botulinum neurotoxins (BoNTs), produced by Clostridium botulinum in an anaerobic environment, are the most toxic polymer proteins. Currently, the most effective modalities for botulism prevention and treatment
Externí odkaz:
https://doaj.org/article/3b3fe064d75d437cbf9daed028543ef6
Autor:
Dan-Yang Shi, Fu-Jia Liu, Zhi-Ying Li, Yun-Yun Mao, Jian-Sheng Lu, Rong Wang, Xiao-Bin Pang, Yun-Zhou Yu, Zhi-Xin Yang
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 5 (2022)
Botulinum neurotoxins (BoNTs) are the most toxic known proteins. Naturally occurring botulism in humans is caused by botulinum serotypes A, B, E, and F. Vaccination is an effective strategy to prevent botulism. In this study, a tetravalent botulinum
Externí odkaz:
https://doaj.org/article/d13fe55a50ff4bd2a4049cbf8dc83890
Autor:
Dan-Yang Shi, Fu-Jia Liu, Yun-Yun Mao, Rong-Tian Cui, Jian-Sheng Lu, Yun-Zhou Yu, Xiao-Jie Dong, Zhi-Xin Yang, Zhi-Wei Sun, Xiao-Bin Pang
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 1, Pp 100-108 (2020)
Botulinum neurotoxins (BoNTs) are among the most toxic proteins. Vaccination is an effective strategy to prevent botulism. To generate a vaccine suitable for human use, a recombinant non-His-tagged isoform of the Hc domain of botulinum neurotoxin ser
Externí odkaz:
https://doaj.org/article/daa233e0453f4fe583f1884004ed4506
Autor:
Dan-Yang Shi, Bo-Yang Chen, Yun-Yun Mao, Guo Zhou, Jian-Sheng Lu, Yun-Zhou Yu, Xiao-Wei Zhou, Zhi-Wei Sun
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 15, Iss 3, Pp 755-760 (2019)
Botulinum neurotoxins (BoNTs) are potential biological weapons because of their high toxicity and mortality. Vaccination is an effective strategy to prevent botulism. The carboxyl-terminus of the heavy chain (Hc domain) is nontoxic and sufficient to
Externí odkaz:
https://doaj.org/article/4a06bc4d6b6e427cbe4429ce7c364220
Characterization of a novel tetravalent botulism antitoxin based on receptor-binding domain of BoNTs
Autor:
Dan-Yang Shi, Jian-Sheng Lu, Yun-Yun Mao, Fu-Jia Liu, Rong Wang, Peng Du, Shuo Yu, Yun-Zhou Yu, Zhi-Xin Yang
Publikováno v:
Applied Microbiology and Biotechnology. 107:3205-3216
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cc0dd8b17c1ae4a31a0b385f6461f5b
https://doi.org/10.1007/s00253-023-12515-2
https://doi.org/10.1007/s00253-023-12515-2
Autor:
Fu-Jia Liu, Yun-Zhou Yu, Zhi-Wei Sun, Dan-Yang Shi, Jian-Sheng Lu, Xiaobin Pang, Yun-Yun Mao, Zhixin Yang, Xiao-Jie Dong, Rong-Tian Cui
Publikováno v:
Hum Vaccin Immunother
Botulinum neurotoxins (BoNTs) are among the most toxic proteins. Vaccination is an effective strategy to prevent botulism. To generate a vaccine suitable for human use, a recombinant non-His-tagged isoform of the Hc domain of botulinum neurotoxin ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea74361b7be6a82505a3b5ee72c017d
https://doi.org/10.1080/21645515.2019.1633878
https://doi.org/10.1080/21645515.2019.1633878
Publikováno v:
Neurotoxicity researchReferences. 39(4)
Botulinum neurotoxin (BoNT) is a neurotoxin produced by Clostridium botulinum in an anaerobic environment. BoNT is the most toxic protein among bacteria, animals, plants, and chemical substances reported to date. BoNTs are 150 kDa proteins composed o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f512bbf34665401d4afe74fde0263c
https://pubmed.ncbi.nlm.nih.gov/33616873
https://pubmed.ncbi.nlm.nih.gov/33616873
Autor:
Jian-Sheng Lu, Xiaobin Pang, Zhixin Yang, Dan-Yang Shi, Zhi-Ying Li, Wang Rong, Yunzhou Yu, Fu-Jia Liu
Publikováno v:
Toxicon : official journal of the International Society on Toxinology. 187
Tetanus is an acute, fatal disease caused by exotoxin produced by Clostridium tetani. The current vaccine against tetanus is based on inactivated tetanus toxin (TeNT). To develop a recombinant TeNT vaccine suitable for replacement of full-length teta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc00cc5ce4f58402db8dc8ea1f39309
https://pubmed.ncbi.nlm.nih.gov/32889026
https://pubmed.ncbi.nlm.nih.gov/32889026
Autor:
Fu-Jia Liu, Yun-Zhou Yu, Xiao-Jie Dong, Jian-Sheng Lu, Xiaobin Pang, Yun-Yun Mao, Dan-Yang Shi, Zhixin Yang, Xiang-Hua Xiong
Publikováno v:
Vaccine. 38(14)
Botulinum neurotoxins (BoNTs) are highly toxic proteins that mediate their effects by binding to neuronal receptors and block the neutralizing ability of therapeutic antibodies. Vaccination is currently the most effective strategy to prevent botulism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bcb696db281a5cb5be8a8c7382ef71
https://pubmed.ncbi.nlm.nih.gov/32113807
https://pubmed.ncbi.nlm.nih.gov/32113807
Autor:
Yun-Zhou Yu, Zhi-Wei Sun, Yun-Yun Mao, Jian-Sheng Lu, Bo-Yang Chen, Guo Zhou, Dan-Yang Shi, Xiao-Wei Zhou
Publikováno v:
Human vaccinesimmunotherapeutics. 15(3)
Botulinum neurotoxins (BoNTs) are potential biological weapons because of their high toxicity and mortality. Vaccination is an effective strategy to prevent botulism. The carboxyl-terminus of the heavy chain (Hc domain) is nontoxic and sufficient to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef03ea99dab6b22fc0b06772c1964f69
https://pubmed.ncbi.nlm.nih.gov/30433836
https://pubmed.ncbi.nlm.nih.gov/30433836