Zobrazeno 1 - 10 of 163 pro vyhledávání: '"Jian Rong, Wang"'
1
Akademický článek
Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability
Autor: Yihua Jiang, Yinxiang Cheng, Mengyuan Xia, Bingrui Zhang, Qiaoce Ding, Liye Lu, Jian-Rong Wang, Xuefeng Mei
Publikováno v: Pharmaceutics, Vol 14, Iss 11, p 2478 (2022)
Dehydroepiandrosterone (DHEA) is an FDA-approved food supplement used as an assisted reproductive sex hormone. The bioavailability is severely limited by its poor solubility (23 µg/mL). Herein, we aimed to modulate its solubility through cocrystalli
Externí odkaz: https://doaj.org/article/ce6f126bf7ee4d30bd7c41bcae7ffa1c
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2
Akademický článek
Cocrystal Prediction of Bexarotene by Graph Convolution Network and Bioavailability Improvement
Autor: Fu Xiao, Yinxiang Cheng, Jian-Rong Wang, Dingyan Wang, Yuanyuan Zhang, Kaixian Chen, Xuefeng Mei, Xiaomin Luo
Publikováno v: Pharmaceutics, Vol 14, Iss 10, p 2198 (2022)
Bexarotene (BEX) was approved by the FDA in 1999 for the treatment of cutaneous T-cell lymphoma (CTCL). The poor aqueous solubility causes the low bioavailability of the drug and thereby limits the clinical application. In this study, we developed a
Externí odkaz: https://doaj.org/article/bb48dbfe1cc540c598a832fb87eba110
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5
Akademický článek
Multifocal electroretinogram in non-pathological myopic subjects: correlation with optical coherence tomography
Autor: Ai-Ping Song, Tao Yu, Jian-Rong Wang, Wei Liu, Yan Sun, Su-Xiang Ma
Publikováno v: International Journal of Ophthalmology, Vol 9, Iss 2, Pp 286-291 (2016)
AIM: To investigate the changes of retinal function in non-pathological myopic subjects using multifocal electroretinography (mfERG) and to correlate the data with the central macular thickness obtained using optical coherence tomography (OCT). METH
Externí odkaz: https://doaj.org/article/f09793ce55834afabd3419f2d1f3be53
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6
Discovery and photosynthesis of sinuaustones A and B, diterpenoids with a novel carbon scaffold isolated from soft coral Sinularia australiensis from Hainan
Autor: Meng-Jun Wu, Dan-Dan Yu, Ming-Zhi Su, Jian-Rong Wang, Lei Gong, Zai-Yong Zhang, Hong Wang, Yue-Wei Guo
Publikováno v: Organic Chemistry Frontiers. 9:5921-5928
Two novel diterpenoids, sinuaustones A (1) and B (2), featuring an unprecedented tricyclo[9.3.1.03,15]tetradecane carbon framework were isolated from the South China Sea soft coral Sinularia australiensis.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d171f337bba7dc2309166de5da4e100a
https://doi.org/10.1039/d2qo01265k
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7
Enhancing the stability of active pharmaceutical ingredients by the cocrystal strategy
Autor: Liyu Liu, Jian-Rong Wang, Xuefeng Mei
Publikováno v: CrystEngComm. 24:2002-2022
Cocrystal strategies to achieve excellent physiochemical performance under different environmental stress were highlighted here. The lattice energy and the energy barrier of degradation reactions are two pillars in a stable cocrystal construction.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da5e98a2782241bf61bd986a8a8751ce
https://doi.org/10.1039/d1ce01327k
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8
Guided Isolation of An Uncommon Cembranoid Orthoester, Sarcotortin A, and Three Skeletal Diverse Terpenoids from the Hainan Soft Coral Sarcophyton tortuosum Based on Molecular Networking Strategy
Autor: Zi‐Hui Chen, Dan‐Dan Yu, Cong Li, Ming‐Zhi Su, Qihao Wu, Zai‐Yong Zhang, Jian‐Rong Wang, Jia Li, Yue‐Wei Guo
Publikováno v: Chemistry – A European Journal. 29
Applying the emerging molecular networking strategy, an uncommon cembranoid orthoester, sarcotortin A (1), featuring a 3/14/8/5-fused scaffold, an unusual eunicellane-type diterpenoid, sarcotorolide A (2), and two new biscembranoids, ximaolides M and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dc70a24d26bac398ebc7393be7b674
https://doi.org/10.1002/chem.202203487
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