Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jian Ken Zhang"'
Autor:
Masahiro Suzuki, Akio Kobayashi, Mitsuru Takahashi, Steven M. Rubenstein, Takuya Matsui, Bei Shan, Kazuyuki Sugimoto, Marie-Louise Smith, Xiaolin Hao, Kexue Li, Yukihito Ishii, Masahiro Tanaka, Jian Ken Zhang, Frank Kayser, Mutsuyoshi Matsushita, Takashi Inaba, Rebekah Choi, Shoichi Sagawa, Nobuya Ogawa, Daisuke Tomimoto, Hidekazu Ozeki, Marc Labelle, Guosen Ye, Atsuhito Yoshida, Chihiro Okuma, Kiyosei Iio, Simon Jackson, Shichang Miao, Brian M. Fox, Noboru Furakawa, Dustin McMinn, Ji Ma
Publikováno v:
Journal of Medicinal Chemistry. 57:3464-3483
The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is described. The SAR of a moderately potent HTS hit was investigated resulting in the discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd66a9d1c69543966b744517a5a81420
https://doi.org/10.1021/jm500135c
https://doi.org/10.1021/jm500135c
Autor:
Karen Siegler, Bei Shan, Mark P. Grillo, Marion Conn, Jiang Zhu, Jian Ken Zhang, Yingcai Wang, Julio C. Medina, Ming Yu, Peter Coward, Frank Kayser, Jiwen Jim Liu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:156-160
The discovery and optimization of novel N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamide GPR119 agonists is described. Modification of the pyridylphthalimide motif of the molecule with R(1)=-Me and R(2)=-(i)Pr su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb68dfdcbb798a04f97abc4c4255b4f
https://doi.org/10.1016/j.bmcl.2013.11.053
https://doi.org/10.1016/j.bmcl.2013.11.053
Autor:
Mark P. Grillo, Karen Siegler, Ming Yu, Jiang Zhu, Peter Coward, Jian Ken Zhang, Frank Kayser, Bei Shan, Yingcai Wang, Julio C. Medina, Marion Conn, Jiwen Jim Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(4)
We describe the discovery and optimization of 5-(2-((1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)oxy)pyridin-4-yl)-1,2,4-oxadiazoles as novel agonists of GPR119. Previously described aniline 2 had suboptimal efficacy in signaling assays using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913cb22d439029d81a0b95924acf2c7f
https://pubmed.ncbi.nlm.nih.gov/24440299
https://pubmed.ncbi.nlm.nih.gov/24440299
Autor:
Jiang Zhu, Bei Shan, Peter Coward, Mark P. Grillo, Frank Kayser, Yingcai Wang, Ming Yu, John Eksterowicz, Jian Ken Zhang, Marion Conn, Julio C. Medina, Jiwen Jim Liu, An-Rong Li, Karen Siegler
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(12)
We describe the discovery of a series of arylsulfonyl 3-(pyridin-2-yloxy)anilines as GPR119 agonists derived from compound 1. Replacement of the three methyl groups in 1 with metabolically stable moieties led to the identification of compound 34, a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c801d0652d0f38f027664d3c6e23433
https://pubmed.ncbi.nlm.nih.gov/23648181
https://pubmed.ncbi.nlm.nih.gov/23648181