Zobrazeno 1 - 10
of 8 838
pro vyhledávání: '"Jian FANG"'
Autor:
Xinyi Chen, Yiran Guo, Ting Zhao, Jiuwei Lu, Jian Fang, Yinsheng Wang, Gang Greg Wang, Jikui Song
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Isoform 1 of DNA methyltransferase DNMT3A (DNMT3A1) specifically recognizes nucleosome monoubiquitylated at histone H2A lysine-119 (H2AK119ub1) for establishment of DNA methylation. Mis-regulation of this process may cause aberrant DNA methy
Externí odkaz:
https://doaj.org/article/f313f491cb134f9da42a75c9d183fafc
Autor:
Yuankai Shi, Xiaohong Han, Qian Zhao, YuLong Zheng, Jianhua Chen, Xinmin Yu, Jian Fang, Yutao Liu, Dingzhi Huang, Tianshu Liu, Hong Shen, Suxia Luo, Hongsheng Yu, Yu Cao, Xi Zhang, Pei Hu
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-12 (2024)
Abstract Background Tunlametinib (HL-085) is a novel, highly selective MEK inhibitor with substantial clinical activities in patients with NRAS-mutant melanoma. This phase I study evaluated the safety and preliminary efficacy of tunlametinib plus vem
Externí odkaz:
https://doaj.org/article/0f192aa657bc4c0d996fc74a75cf28e7
Autor:
Caicun Zhou, MD, PhD, You Lu, MD, Sang-We Kim, MD, PhD, Thanyanan Reungwetwattana, MD, Jianying Zhou, MD, Yiping Zhang, MD, Jianxing He, MD, PhD, Jin-Ji Yang, MD, Ying Cheng, MD, Se-Hoon Lee, MD, PhD, Jianhua Chang, MD, Jian Fang, MD, Zhe Liu, PhD, Lilian Bu, MSc, Li Qian, MD, Tingting Xu, MD, Venice Archer, MB ChB, MSc, Magalie Hilton, MSc, Mingzhu Zhou, MSc, Li Zhang, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 9, Pp 100700- (2024)
Introduction: Previous results from the phase 3 ALESIA study (NCT02838420) revealed that alectinib (a central nervous system [CNS]-active, ALK inhibitor) had clinical benefits in treatment-naïve Asian patients with advanced ALK-positive NSCLC, consi
Externí odkaz:
https://doaj.org/article/0adb5b401a534eba8c323105cdaa5a38
Autor:
Jieran Long, Xuefei Li, Lin Wu, Guohua Yu, Aimin Zang, Yanqiu Zhao, Jinsheng Shi, Ligong Nie, Xuan Zhao, Jian Fang
Publikováno v:
Cancer Medicine, Vol 13, Iss 17, Pp n/a-n/a (2024)
Abstract Purpose To evaluate the safety, tolerability, and preliminary efficacy of multiple doses of pegylated irinotecan (JK1201I) as a second‐line monotherapy for treating small‐cell lung cancer (SCLC) patients. Methods According to the “3 +
Externí odkaz:
https://doaj.org/article/c0eff1742b674608ab739db3cf6ba979
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract Solar‐driven interfacial evaporation is an emerging desalination technology that can potentially relieve the freshwater scarcity issue. To obtain high and continuous evaporation rates for all‐weather, chemically engineered structural mat
Externí odkaz:
https://doaj.org/article/a410981b6f964299aa807a9bd6646e60
Publikováno v:
International Journal of Applied Earth Observations and Geoinformation, Vol 132, Iss , Pp 104049- (2024)
The point-based 3D object detection method is highly advantageous due to its lightweight nature and fast inference speed, making it a valuable asset in engineering fields such as intelligent transportation and autonomous driving. However, current adv
Externí odkaz:
https://doaj.org/article/2043af5d25e54a5fad6f9a1542328025
Autor:
Jing Zheng, Tao Wang, Yunpeng Yang, Jie Huang, Jifeng Feng, Wu Zhuang, Jianhua Chen, Jun Zhao, Wei Zhong, Yanqiu Zhao, Yiping Zhang, Yong Song, Yi Hu, Zhuang Yu, Youling Gong, Yuan Chen, Feng Ye, Shucai Zhang, Lejie Cao, Yun Fan, Gang Wu, Yubiao Guo, Chengzhi Zhou, Kewei Ma, Jian Fang, Weineng Feng, Yunpeng Liu, Zhendong Zheng, Gaofeng Li, Huijie Wang, Shundong Cang, Ning Wu, Wei Song, Xiaoqing Liu, Shijun Zhao, Lieming Ding, Giovanni Selvaggi, Yang Wang, Shanshan Xiao, Qian Wang, Zhilin Shen, Jianya Zhou, Jianying Zhou, Li Zhang
Publikováno v:
Cancer Communications, Vol 44, Iss 4, Pp 455-468 (2024)
Abstract Background The initial phase II stuty (NCT03215693) demonstrated that ensartinib has shown clinical activity in patients with advanced crizotinib‐refractory, anaplastic lymphoma kinase (ALK)‐positive non‐small cell lung cancer (NSCLC).
Externí odkaz:
https://doaj.org/article/dcd1b31af767472781f48f4856ca4755
Autor:
Lingling Shen, Jian Fang, Lulu Liu, Fei Yang, Jeremy L. Jenkins, Peter S. Kutchukian, He Wang
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract We present a user-friendly molecular generative pipeline called Pocket Crafter, specifically designed to facilitate hit finding activity in the drug discovery process. This workflow utilized a three-dimensional (3D) generative modeling metho
Externí odkaz:
https://doaj.org/article/3862345979da4f6a9f6a00a5c376a88d
Autor:
Congjie Wang, Jian Fang, Tingshu Jiang, Shanliang Hu, Ping Wang, Xiuli Liu, Shenchun Zou, Jun Yang
Publikováno v:
EJNMMI Physics, Vol 11, Iss 1, Pp 1-16 (2024)
Abstract Background We combined the metabolic features of 18F-FDG-PET/CT and hematological inflammatory indicators to establish a predictive model of the outcomes of patients with locally advanced non-small cell lung cancer (LA-NSCLC) receiving concu
Externí odkaz:
https://doaj.org/article/22dcd0ab69e44769930c09234119cecb
Publikováno v:
AIP Advances, Vol 14, Iss 6, Pp 065130-065130-11 (2024)
The safe and stable operation of the transformer is the key to ensure the reliable operation of the power grid. Loose windings will produce a vibration acceleration signal with twice the power supply frequency signal, i.e., 100 Hz, as the main spectr
Externí odkaz:
https://doaj.org/article/1de744813c51477fb61a07139aae7678