Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jian‐chang Qian"'
Autor:
Li-Qun Zhang, Xin-Yue Li, Lian-Guo Chen, Zhe Chen, Ren-Ai Xu, Jian-Chang Qian, Xiao-yang Zhou, Da-Peng Dai, Guo-Xin Hu, Jian-Ping Cai
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28952- (2024)
Amino acid variants in protein may result in deleterious effects on enzymatic activity. In this study we investigate the DNA variants on activity of CYP2B6 gene in a Chinese Han population for potential use in precision medicine. All exons in CYP2B6
Externí odkaz:
https://doaj.org/article/5743bf114bd14db7a0d8f78ea271d104
Autor:
Zi-Hui Wang, Jin Li, Qian Liu, Jian-Chang Qian, Qing-Qing Li, Qing-Yu Wang, Lv-Tao Zeng, Si-Jia Li, Xin Gao, Jia-Xin Pan, Xu-Fan Gao, Kun Wu, Guo-Xin Hu, Tomoo Iwakuma, Jian-Ping Cai
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 106990- (2024)
Resistance to temozolomide (TMZ), the frontline chemotherapeutic agent for glioblastoma (GBM), has emerged as a formidable obstacle, underscoring the imperative to identify alternative therapeutic strategies to improve patient outcomes. In this study
Externí odkaz:
https://doaj.org/article/58f2957d9e08467d92747532f864bc98
Autor:
Su-su Bao, Peng-fei Tang, Nan-yong Gao, Zhong-xiang Xiao, Jian-chang Qian, Long Zheng, Guo-xin Hu, Huan-hai Xu
Publikováno v:
PeerJ, Vol 11, p e16051 (2023)
Since the combination of anticancer drugs and opioids is very common, apatinib and tramadol are likely to be used in combination clinically. This study evaluated the effects of apatinib on the pharmacokinetics of tramadol and its main metabolite O-de
Externí odkaz:
https://doaj.org/article/ae58c2d0561f44daa86958c6fe8c3724
Autor:
Wu Luo, Lin Ye, Xue‐ting Hu, Mei‐hong Wang, Min‐xiu Wang, Lei‐ming Jin, Zhong‐xiang Xiao, Jian‐chang Qian, Yi Wang, Wei Zuo, Li‐jiang Huang, Guang Liang
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Background Non‐alcoholic fatty liver disease (NAFLD) is the most predominant form of liver diseases worldwide. Recent evidence shows that myeloid differentiation factor 2 (MD2), a protein in innate immunity and inflammation, regulates live
Externí odkaz:
https://doaj.org/article/ce919cf5b5e8430cb70a7d56d0bc3ad7
Autor:
Zhe Wang, Le-jing Lian, Yan-yan Dong, Xiao Cui, Jian-chang Qian, Cheng-ke Huang, Rui-jie Chen, Wei Sun
Publikováno v:
Journal of Analytical Methods in Chemistry, Vol 2019 (2019)
Anlotinib is a novel inhibitor of receptor kinase tyrosine with multitargets and has a broad spectrum of inhibitory action on tumor angiogenesis and growth. A simple and rapid UHPLC-MS/MS bioanalytical method was validated for the determination of an
Externí odkaz:
https://doaj.org/article/3989e973101843e19b1faf4e71a439e9
Autor:
Min-Xiu, Wang, Wu, Luo, Lin, Ye, Lei-Ming, Jin, Bin, Yang, Qian-Hui, Zhang, Jian-Chang, Qian, Yi, Wang, Yi, Zhang, Guang, Liang
Publikováno v:
Acta Pharmacologica Sinica. 44:120-132
The innate immune response and inflammation contribute to hepatic steatosis and non-alcoholic fatty liver disease (NAFLD). Dectin-1 is a pathogen recognition receptor in innate immunity. In this study, we investigated the role of Dectin-1 in the path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6174c39c427bcee8651e46ce6014c1
https://doi.org/10.1038/s41401-022-00926-2
https://doi.org/10.1038/s41401-022-00926-2
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 17:707-716
Introduction: Cytochrome P450 (CYP) is a monooxygenase superfamily mediating the elimination of anti-hypertensive drugs. Polymorphisms of CYP would lead to differential drug efficacy. Building relationships between genotype and phenotype will benefit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe72fdd35bd4b8d5ae8dfcfe7b7d318
https://doi.org/10.1080/17425255.2021.1921147
https://doi.org/10.1080/17425255.2021.1921147
Autor:
Jian-Ping Cai, Guo-Xin Hu, Peng-fei Tang, Cheng-cheng Yang, Jian-chang Qian, Xiang Zheng, Zhe Chen, Xiao-xia Hu
Publikováno v:
Drug Design, Development and Therapy. 14:5129-5141
Aim We aimed to systematically examine the effects of enzymatic activity of 38 human CYP2C9 alleles and 21 human CYP3A4 alleles, including wild-type CYP2C9.1 and CYP3A4.1, which contain the 24 CYP2C9 novel alleles (*36–*60) and 6 CYP3A4 novel allel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7318e20b867d102785d85fe34b63fb9
https://doi.org/10.2147/dddt.s268796
https://doi.org/10.2147/dddt.s268796
Autor:
Bingbing Chen, Wei-wei You, Ying-Hui Li, Xiao-dan Zhang, Xiao-xia Hu, Jian-chang Qian, Daoxing Chen, Guo-Xin Hu
Publikováno v:
Journal of Pharmacy and Pharmacology. 72:1405-1411
Objective In this study, we aimed to investigate the potential interaction of apatinib and buspirone and underlying mechanism. Methods UPLC-MS/MS assay was applied to determine the concentrations of buspirone and its main metabolites (1-PP and 6-OH b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc54adf2bd24c43dd400595bb9aaaca
https://doi.org/10.1111/jphp.13320
https://doi.org/10.1111/jphp.13320
Autor:
Ren-ai Xu, Qing-qing Li, Nan-yong Gao, Jing Wang, Xin-yue Li, Feng Ye, Jin-huan Ni, Guo-xin Hu, Jian-chang Qian
Publikováno v:
Food and Chemical Toxicology. 174:113669
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e540139e738b2c1469183ce0ffe0e3
https://doi.org/10.1016/j.fct.2023.113669
https://doi.org/10.1016/j.fct.2023.113669