Zobrazeno 1 - 10
of 626
pro vyhledávání: '"Jian‐Zhi Wang"'
Autor:
Fang Huang, Xinghua Liu, Qian Guo, Yacoubou Abdoul Razak Mahaman, Bin Zhang, Jian-Zhi Wang, Hongbin Luo, Rong Liu, Xiaochuan Wang
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Social isolation (SI) is a common phenomenon in the modern world, especially during the coronavirus disease 2019 pandemic, and causes lasting cognitive impairments and mental disorders. However, it is still unclear how SI alters molecules in
Externí odkaz:
https://doaj.org/article/5175c82cf4eb4c81b4a7fe7a06d1bc71
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-48 (2024)
Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder, characterized pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and intracellular accumulation of hyperphosphorylated tau (pTau) as ne
Externí odkaz:
https://doaj.org/article/7e1c77e3b8ed40e2ae273155ed209e53
Autor:
Xin Wang, Qian Liu, Hai-tao Yu, Jia-zhao Xie, Jun-ning Zhao, Zhi-ting Fang, Min Qu, Yao Zhang, Ying Yang, Jian-Zhi Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/0b78d85f2ec4455bb98356fcd1f1bdc8
Autor:
Xin Wang, Qian Liu, Hai-tao Yu, Jia-zhao Xie, Jun-ning Zhao, Zhi-ting Fang, Min Qu, Yao Zhang, Ying Yang, Jian-Zhi Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease (AD); however, the fundamental mechanism is unknown. In this study, we found a substantial decline in isocitrate dehydrogenase 3β (IDH3β) levels, a critical t
Externí odkaz:
https://doaj.org/article/22e1bd0e6c8343b5b706b6eaa267e54b
Autor:
Hui-Yang Lei, Gui-Lin Pi, Ting He, Rui Xiong, Jing-Ru Lv, Jia-Le Liu, Dong-Qin Wu, Meng-Zhu Li, Kun Shi, Shi-Hong Li, Na-Na Yu, Yang Gao, Hui-Ling Yu, Lin-Yu Wei, Xin Wang, Qiu-Zhi Zhou, Pei-Lin Zou, Jia-Yang Zhou, Ying-Zhou Liu, Nai-Ting Shen, Jie Yang, Dan Ke, Qun Wang, Gong-Ping Liu, Xi-Fei Yang, Jian-Zhi Wang, Ying Yang
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-24 (2024)
Abstract Background Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the specific roles of diffe
Externí odkaz:
https://doaj.org/article/df673dbc95c04f9d9dc2c62b7ff993ba
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Protein post-translational modifications (PPTMs) refer to a series of chemical modifications that occur after the synthesis of protein. Proteins undergo different modifications such as phosphorylation, acetylation, ubiquitination, and so on.
Externí odkaz:
https://doaj.org/article/32d2729dee544eca83e8094c3099c37d
Autor:
Yang Gao, Yuying Wang, Huiyang Lei, Zhendong Xu, Shihong Li, Haitao Yu, Jiazhao Xie, Zhentao Zhang, Gongping Liu, Yao Zhang, Jie Zheng, Jian-Zhi Wang
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-15 (2023)
Abstract Background Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of Alzheimer’s disease (AD). However, mouse models imitating AD-exclusive neuronal tau pathologies are lacking. Methods We generated a new tet-on trans
Externí odkaz:
https://doaj.org/article/2c87f6cabb794cbcb2d49af1789302e8
Autor:
Zhendong Xu, Jichang Hu, Zhen Wei, Yu Lei, Henok Kessete Afewerky, Yang Gao, Lu Wan, Longfei Li, Ling Lei, Yi Liu, Fang Huang, Tong Yu, Jian‐Zhi Wang, Hong‐Lian Li, Rong Liu, Xiaochuan Wang
Publikováno v:
MedComm, Vol 5, Iss 4, Pp n/a-n/a (2024)
Abstract Senile plaque, composed of amyloid β protein (Aβ) aggregates, is a critical pathological feature in Alzheimer's disease (AD), leading to cognitive dysfunction. However, how Aβ aggregates exert age‐dependent toxicity and temporal cogniti
Externí odkaz:
https://doaj.org/article/62d0d1779abc4c23b5ba94d28a53baad
Autor:
Yang Gao, Yuying Wang, Huiyang Lei, Zhendong Xu, Shihong Li, Haitao Yu, Jiazhao Xie, Zhentao Zhang, Gongping Liu, Yao Zhang, Jie Zheng, Jian‑Zhi Wang
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/c5997c37c6234ecba8753c48a298e3c8
Autor:
Dongqin Wu, Nana Yu, Yang Gao, Rui Xiong, Luping Liu, Huiyang Lei, Sen Jin, Jiale Liu, Yingzhou Liu, Jiazhao Xie, Enjie Liu, Qiuzhi Zhou, Yanchao Liu, Shihong Li, Linyu Wei, Jingru Lv, Huilin Yu, Wenbo Zeng, Qiang Zhou, Fuqiang Xu, Min-Hua Luo, Yao Zhang, Ying Yang, Jian-Zhi Wang
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-20 (2023)
Abstract Background Abnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer’s disease (AD). However, the sensitivity of cholinergic neurons to AD-like tau accumulation and strategies
Externí odkaz:
https://doaj.org/article/39fe4c579b394e849b92ba74dcf1104c