Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Jian‐Xiong Chen"'
Autor:
Umesh Bhattarai, Rui Xu, Xiaochen He, Lihong Pan, Ziru Niu, Dongzhi Wang, Heng Zeng, Jian-Xiong Chen, John S. Clemmer, Yingjie Chen
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103325- (2024)
Selenium (Se) deficiency is associated with the development of Keshan disease, a cardiomyopathy associated with massive cardiac immune cell infiltration that can lead to heart failure (HF). The purpose of this study was to determine whether high Se d
Externí odkaz:
https://doaj.org/article/bfdb56c22ffa4f6abe32a0eca6ee3975
Autor:
Bo Liu, Heng Zeng, Han Su, Quinesha A. Williams, Jessie Besanson, Yingjie Chen, Jian‐Xiong Chen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 16 (2024)
Background Endothelial prolyl hydroxylase‐2 (PHD2) is essential for pulmonary remodeling and hypertension. In the present study, we investigated the role of endothelial PHD2 in angiotensin II–mediated arterial stiffness, pericyte recruitment, and
Externí odkaz:
https://doaj.org/article/9162e368d9a64a469bdf6a5a2833ab7c
Autor:
Xiaochen He, Quinesha A. Williams, Aubrey C. Cantrell, Jessie Besanson, Heng Zeng, Jian-Xiong Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2433 (2024)
Hypertension is the key contributor to pathological cardiac hypertrophy. Growing evidence indicates that glucose metabolism plays an essential role in cardiac hypertrophy. TP53-induced glycolysis and apoptosis regulator (TIGAR) has been shown to regu
Externí odkaz:
https://doaj.org/article/637f66e6f6834ff98bb15be04ff60b87
Autor:
Xiaochen He, Rui Xu, Lihong Pan, Umesh Bhattarai, Xiaoguang Liu, Heng Zeng, Jian-Xiong Chen, Michael E. Hall, Yingjie Chen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundInflammation contributes to heart failure (HF) development, the progression from left ventricular failure to pulmonary remodeling, and the consequent right ventricular hypertrophy and failure. NK1.1 plays a critical role in Natural killer (
Externí odkaz:
https://doaj.org/article/2c79674ee7fc470fb2e897799340465f
Autor:
Umesh Bhattarai, Xiaochen He, Rui Xu, Xiaoguang Liu, Lihong Pan, Yuxiang Sun, Jian-Xiong Chen, Yingjie Chen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IL-12α plays an important role in modulating inflammatory response, fibroblast proliferation and angiogenesis through modulating macrophage polarization or T cell function, but its effect on cardiorespiratory fitness is not clear. Here, we studied t
Externí odkaz:
https://doaj.org/article/5fcab531b0294b588b2cc6e8951c2e1e
Publikováno v:
Cells, Vol 12, Iss 10, p 1428 (2023)
Cardiac fibrosis plays an essential role in the development of diastolic dysfunction and contributes to heart failure with preserved ejection fraction (HFpEF). Our previous studies suggested Sirtuin 3 (SIRT3) as a potential target for cardiac fibrosi
Externí odkaz:
https://doaj.org/article/550926eac8ad4ba28486c308f12dc2b5
Publikováno v:
Cells, Vol 12, Iss 7, p 1060 (2023)
The induction of hypoxia tolerance has emerged as a novel therapeutic strategy for the treatment of ischemic diseases. The disruption of hypoxic signaling by hyperglycemia has been shown to contribute to diabetic cardiomyopathy. In this study, we exp
Externí odkaz:
https://doaj.org/article/d5abf02186db48c792f6027249ef7fa9
Publikováno v:
Physiological Reports, Vol 10, Iss 8, Pp n/a-n/a (2022)
Abstract Angiotensin II (Ang‐II) is one of the major contributors to the progression of renal fibrosis, inflammation, glomerular injury, and chronic kidney disease. Emerging evidence suggests that renal glycolysis plays an important role in renal f
Externí odkaz:
https://doaj.org/article/6eb662de8baf43abbbcaba403fb10c43
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 5 (2021)
Background Impairment of glycolytic metabolism is suggested to contribute to diabetic cardiomyopathy. In this study, we explored the roles of SIRT3 (Sirtuin 3) on cardiomyocyte glucose metabolism and cardiac function. Methods and Results Exposure of
Externí odkaz:
https://doaj.org/article/2bd34f19dce14772ab834a9266876df6
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 18 (2020)
Background Coronary microvascular dysfunction is common in patients of myocardial infarction with non‐obstructive coronary artery disease. Coronary flow reserve (CFR) reflects coronary microvascular function and is a powerful independent index of c
Externí odkaz:
https://doaj.org/article/2b72a5bdf3084f3a80cf4638e0c5e058