The viscoelasticity of high concentration monoclonal antibodies using particle tracking microrheology

Autor: Conor M. Lewis, Charles T. Heise, Natalia Harasimiuk, Jennifer Tovey, Jian R. Lu, Thomas A. Waigh

Publikováno v: APL Bioengineering, Vol 8, Iss 2, Pp 026105-026105-8 (2024)

The viscoelasticity of monoclonal antibodies (mAbs) is important during their production, formulation, and drug delivery. High concentration mAbs can provide higher efficacy therapeutics (e.g., during immunotherapy) and improved efficiency during the

Externí odkaz: https://doaj.org/article/3f9f7e7dde6947139450411208214f3a

Unlocking roles of cationic and aromatic residues in peptide amphiphiles in treating drug-resistant gram-positive pathogens

Autor: Liao, Mingrui, Gong, Haoning, Shen, Kangcheng, Wang, Ziwei, Li, Renzhi, Campana, Mario, Hu, Xuzhi, Lu, Jian R.

Publikováno v: In Journal of Colloid And Interface Science 15 October 2024 672:209-223

Combination of a pH-responsive peptide amphiphile and a conventional antibiotic in treating Gram-negative bacteria

Autor: Liao, Mingrui, Gong, Haoning, Liu, Huayang, Shen, Kangcheng, Ge, Tianhao, King, Stephen, Schweins, Ralf, McBain, Andrew J., Hu, Xuzhi, Lu, Jian R.

Publikováno v: In Journal of Colloid And Interface Science April 2024 659:397-412

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Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis.

Autor: Esplin ED; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Hanson C; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Wu S; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Horning AM; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Barapour N; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Nevins SA; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Jiang L; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Contrepois K; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Lee H; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Guha TK; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Hu Z; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA.; Department of Medicine, Stanford School of Medicine, Stanford, CA, USA., Laquindanum R; Department of Medicine, Stanford School of Medicine, Stanford, CA, USA., Mills MA; Department of Medicine, Stanford School of Medicine, Stanford, CA, USA., Chaib H; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Chiu R; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Jian R; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Chan J; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Ellenberger M; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Becker WR; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Bahmani B; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Khan A; Stanford Cancer Institute, Stanford School of Medicine, Stanford, CA, USA., Michael B; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Weimer AK; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Esplin DG; Animal Reference Pathology, Salt Lake City, UT, USA., Shen J; Department of Pathology, Stanford School of Medicine, Stanford, CA, USA., Lancaster S; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Monte E; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Karathanos TV; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA., Ladabaum U; Department of Medicine, Stanford School of Medicine, Stanford, CA, USA., Longacre TA; Department of Pathology, Stanford School of Medicine, Stanford, CA, USA., Kundaje A; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Curtis C; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA.; Department of Medicine, Stanford School of Medicine, Stanford, CA, USA., Greenleaf WJ; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Ford JM; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA. jmf@stanford.edu.; Department of Medicine, Stanford School of Medicine, Stanford, CA, USA. jmf@stanford.edu., Snyder MP; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA. mpsnyder@stanford.edu.

Publikováno v: Nature cancer [Nat Cancer] 2024 Oct 30. Date of Electronic Publication: 2024 Oct 30.