Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Jialei Sun"'
Autor:
Zhiqiang Duan, Yafeng Liang, Jialei Sun, Hongjin Zheng, Tong Lin, Pengyu Luo, Mengge Wang, Ruiheng Liu, Ying Chen, Shuhua Guo, Nannan Jia, Hongtao Xie, Meili Zhou, Minghui Xia, Kaijun Zhao, Shuhui Wang, Na Liu, Yongling Jia, Wei Si, Qitong Chen, Yechun Hong, Ruilin Tian, Jian-Kang Zhu
Publikováno v:
The Innovation, Vol 5, Iss 2, Pp 100564- (2024)
Summary: The type V-I CRISPR-Cas system is becoming increasingly more attractive for genome editing. However, natural nucleases of this system often exhibit low efficiency, limiting their application. Here, we used structure-guided rational design an
Externí odkaz:
https://doaj.org/article/073f0f0a881f4624ac8c5343f77182b5
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract The pluripotency of naïve mouse embryonic stem cells (mES) is regulated by multiple signaling pathways, with inhibition of protein kinase C (PKCi) playing a particularly important role in maintaining naïve mES. However, the regulatory func
Externí odkaz:
https://doaj.org/article/13ba459e2be1406d99e2cd63f4aeea91
Autor:
Lu Luo, Chaofeng Li, Nanxi Huang, Qiaochu Wang, Zihao Zhang, Chen Song, Hui Yang, Maowen Yuan, Ziwen Xu, Jialei Sun, Zhijie Zhang
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionRealgar has a long history ofuse in traditional medicines. However, the mechanism through which Realgar or Realgar-Indigo naturalis formula (RIF) exert therapeutic effects is only partially understood.MethodsIn this study, 60 feces and 60
Externí odkaz:
https://doaj.org/article/6c6cb9dbfc9944378a8c030b7d1cf659
Autor:
Qiang Zhou, Yirui Yin, Mincheng Yu, Dongmei Gao, Jialei Sun, Zhangfu Yang, Jialei Weng, Wanyong Chen, Manar Atyah, Yinghao Shen, Qinghai Ye, Chia-Wei Li, Mien-Chie Hung, Qiongzhu Dong, Chenhao Zhou, Ning Ren
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102458- (2022)
Guanosine triphosphate binding protein 4 (GTPBP4) is a key regulator of cell cycle progression and MAPK activation. However, how its biological properties intersect with cellular metabolism in hepatocellular carcinoma (HCC) development remains poorly
Externí odkaz:
https://doaj.org/article/2e2ca52003b14f249f26ef0b3ba708fc
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
ObjectiveTo examine the relationship between fear of recurrence and depression in patients with cancer.Materials and methodsTwo hundred and fifty-nine participants completed self-report questionnaires, including the Fear of Progression Questionnaire-
Externí odkaz:
https://doaj.org/article/48a8f8dd7311438abf35f241d8f97fe4
Publikováno v:
Frontiers in Psychology, Vol 13 (2022)
ObjectiveTo examine the relationship among childhood trauma, acceptance, positive reappraisal and post-traumatic growth (PTG) among college students.MethodsResearch participants were selected by random cluster sampling. 1,028 college students (62.6%
Externí odkaz:
https://doaj.org/article/69d5803b9969479999d500746b31f068
Publikováno v:
Foods, Vol 12, Iss 4, p 787 (2023)
Compared with the commonly used technique of freeze-drying, spray drying has lower energy costs. However, spray drying also has a fatal disadvantage: a lower survival rate. In this study, the survival of bacteria in a spray-drying tower decreased as
Externí odkaz:
https://doaj.org/article/b4c92e0d00f04f2aa7137a78361387bd
Autor:
Mengzhou Guo, Feifei Yuan, Feng Qi, Jialei Sun, Qianwen Rao, Zhiying Zhao, Peixin Huang, Tingting Fang, Biwei Yang, Jinglin Xia
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-13 (2020)
Abstract Background Fibrinogen-like protein 1 (FGL1)—Lymphocyte activating gene 3 (LAG-3) pathway is a promising immunotherapeutic target and has synergistic effect with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1). However, the prog
Externí odkaz:
https://doaj.org/article/920e89abec214bd8b5a5b909ec16273d
Autor:
Mengzhou Guo, Feng Qi, Qianwen Rao, Jialei Sun, Xiaojing Du, Zhuoran Qi, Biwei Yang, Jinglin Xia
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundTransarterial chemoembolization (TACE) stands for the most commonly utilized therapy for hepatocellular carcinoma (HCC) worldwide. This study was to explore the potential predictive and prognostic roles of LAG-3 and PD-L1 as serum biomarker
Externí odkaz:
https://doaj.org/article/c09de356d78f46678d2e1e92f2ccb3a3
Autor:
Jialei Sun, Chenhao Zhou, Yue Zhao, Xiaofei Zhang, Wanyong Chen, Qiang Zhou, Bo Hu, Dongmei Gao, Lisa Raatz, Zhefang Wang, Peter J. Nelson, Yuchao Jiang, Ning Ren, Christiane J. Bruns, Haijun Zhou
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101942- (2021)
Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), but its clinical effects are still limited. In this study we identify Quiescin sulfhydryl oxidase 1 (QSOX1) acting as a cellular pro-oxidant, specifically in
Externí odkaz:
https://doaj.org/article/27aec234849244f1a00bdde094614739